Dyspepsia

This study tests whether a newer acid-reducing drug (vonoprazan) works better than a standard one (esomeprazole) for clearing H. pylori, a bacteria that can cause stomach ulcers and indigestion. About 80 adults with H. pylori will take one of the two drug combinations for 14 days…

This study tests a new way to treat children with gut-brain disorders like cyclic vomiting and functional dyspepsia. The therapy uses a mild electrical nerve stimulation to the ear, personalized based on each child's nerve activity. The goal is to improve quality of life and redu…

This study tests whether adding a probiotic called Saccharomyces boulardii to a standard antibiotic cocktail helps clear Helicobacter pylori infections that didn't respond to earlier treatments. About 1,248 adults who have failed prior H. pylori therapy will be randomly assigned …

This study compares intravenous famotidine (a stomach acid reducer) and oral antacids (like Maalox) for treating dyspepsia (stomach pain) in the emergency department. About 80 adults with upper abdominal pain will rate their pain every 15 minutes for an hour. The goal is to see w…

This study looks at how different FODMAP diets affect gut bacteria, gut barrier function, and symptoms in people with functional gastrointestinal disorders like IBS. About 60 adults will follow either a low FODMAP, gentle FODMAP, or standard dietary advice for two weeks. Research…

This study tests whether two medications, amitriptyline and trifluoperazine, can reduce stomach symptoms in people with functional dyspepsia—a condition where the stomach feels upset without a clear cause. About 120 adults will take one of the drugs or stick with standard treatme…

This study looks at why people with indigestion and diabetes have stomach issues, possibly due to increased sensitivity in the small intestine. Researchers are testing ondansetron, a drug used for nausea, to see if it can reduce symptoms like fullness, discomfort, and nausea. The…

This study tests whether a natural extract from the hyacinth bean (EDL) can reduce stomach symptoms like pain, fullness, and burning in people with functional dyspepsia. About 100 adults will take EDL or a placebo daily for 12 weeks. Researchers will measure symptom changes using…

This study tests whether domperidone, a drug that helps the stomach empty food, can reduce symptoms like pain, bloating, nausea, and vomiting in people with chronic digestive disorders. About 200 patients who have not improved with standard treatments will take domperidone and re…

This study is testing whether a daily capsule of holy basil extract can reduce stomach inflammation and improve symptoms like pain, bloating, and nausea in adults with indigestion. Twenty-seven participants will take the supplement for 28 days and undergo endoscopies and blood te…

This study tests whether wearing virtual reality goggles during a colonoscopy or upper endoscopy can help patients need less sedation. Ten adults aged 21 to 65 will receive minimal sedation and wear a VR headset during the procedure. Researchers will measure how much sedative is …

This study tests if a digital hypnotherapy program can reduce stomach and gut symptoms like pain, bloating, and nausea. Researchers will enroll 100 adults with upper GI disorders (e.g., functional dyspepsia) and measure changes using symptom questionnaires. The approach is non-in…

This study tests whether pressing small seeds on specific ear points can help people with functional dyspepsia (chronic stomach discomfort) who also have insomnia. Researchers will track symptom relief and sleep quality in 176 adults over 8 weeks, and explore how the treatment af…

This Phase 3 trial tests whether Lianxiaxiaopi Granules, a traditional Chinese herbal medicine, can relieve symptoms of postprandial distress syndrome (stomach discomfort, fullness, or early fullness after meals). 342 adults aged 18-65 will take the granules or a placebo three ti…

This study tests whether using virtual reality can help relieve stomach pain and other symptoms in people with functional dyspepsia, a condition where the stomach feels upset without a clear cause. Researchers at Mayo Clinic will enroll 30 adults who meet specific criteria. Parti…

This study tests whether ketotifen, a drug that stabilizes certain immune cells, can reduce stomach pain in children aged 8-17 with functional dyspepsia and high levels of eosinophils in the gut. Participants will receive both ketotifen and a placebo at different times to compare…

This study tests two digital treatments for children aged 8-17 with chronic stomach pain caused by gut-brain interaction disorders. After a 4-week online education program, participants are randomly assigned to either internet-based cognitive behavioral therapy (iCBT) or gut-dire…

This study tests a daily supplement containing two types of probiotics and ginger extract in 198 adults with functional dyspepsia, a condition causing stomach pain, fullness, and burning. Participants take one capsule daily for 8 weeks. Researchers will measure changes in symptom…

This study tests whether a probiotic called Clostridium butyricum can help reduce anxiety and depression in people with functional dyspepsia (a common stomach disorder). 180 adults will receive either the probiotic or a placebo for 4 weeks, alongside standard stomach medication. …

This study tests whether a probiotic called Bacillus coagulans can reduce anxiety and depression in people with functional dyspepsia, a common stomach disorder. 180 adults will receive either the probiotic or a placebo for 4 weeks, alongside standard treatment. The main goal is t…

This study tests whether combining a nerve-stimulating device (placed on the ear) with behavioral therapy can reduce stomach pain and anxiety in people with functional dyspepsia, a condition where the stomach feels upset without a clear cause. Researchers will track symptoms and …

This study tests whether a simple biofeedback technique—teaching people to control their abdominal and chest muscles using a video—can reduce visible bloating after meals. 100 adults with irritable bowel syndrome, dyspepsia, or functional bloating will be randomly assigned to eit…

This study tests whether press needles (small needles taped to the skin) on body and ear acupuncture points, combined with medication, can reduce symptoms and improve quality of life in people with functional dyspepsia (stomach pain or discomfort without a clear cause). About 38 …

This study tests a type of talking therapy called exposure-based cognitive behavioral therapy (CBT) for adults who have both functional dyspepsia (a stomach condition causing pain and fullness) and avoidant/restrictive food intake disorder (ARFID), leading to weight loss. Fifty p…

This study tests a drink made from Chios mastic, a natural resin, to see if it can reduce indigestion symptoms. Sixty adults with dyspepsia will drink either the mastic beverage or a placebo daily for three months. Researchers will measure changes in symptom severity and quality …

This study aims to collect medical data and biological samples (blood, urine, stool, and tissue) from up to 4,000 adults with known or suspected gastrointestinal diseases. Participants receive standard medical care at the NIH, and any extra samples or leftover tissue from procedu…

This study tests a non-invasive device called Gastric Alimetry that records stomach electrical activity in people with functional dyspepsia or gastroparesis. Researchers will compare recordings taken before and during medication to see if the device can predict which treatment wo…

This study aims to find out how many relatives of people with celiac disease have non-celiac wheat sensitivity (NCWS) or other gut issues like IBS. Participants will follow a strict wheat-free diet for 6 weeks and report their symptoms. The goal is to better understand the link b…

This observational study is investigating whether heterotopic gastric mucosa (HGM), a patch of stomach-like tissue found in the upper esophagus, is associated with swallowing difficulties (dysphagia) and indigestion (dyspepsia). Researchers will compare symptoms and quality of li…

This study is creating a registry of 250 people with symptoms of gastroparesis or functional dyspepsia, such as nausea, vomiting, and abdominal pain. Participants will fill out questionnaires, take a nutrient drink test, and have a gastric emptying scan. The goal is to collect da…

This observational study aims to understand stomach electrical activity in children aged 8-25 with digestive issues like slow stomach emptying or chronic pain. Researchers will use a non-invasive device (BSGM) to record stomach signals for up to 4 hours and compare them to health…

This study is following 2000 adults with functional digestive disorders like irritable bowel syndrome, dyspepsia, and constipation. Researchers will collect medical data and biological samples (biopsies, blood, urine, stool) during routine care. The goal is to find markers that c…

This observational study measures the carbon footprint produced during upper GI endoscopy in 75 patients with either dyspepsia (diagnostic scope) or non-variceal upper GI bleeding (therapeutic scope). Researchers track emissions from when a patient enters the endoscopy room until…

This study looks at whether people with a certain stomach lining condition (chronic atrophic gastritis) have different indigestion symptoms than those without it. Researchers will compare symptom patterns in about 315 adults who recently had an endoscopy. The goal is to better un…

This study uses a noninvasive device to stimulate a nerve in the ear and see how it changes brain and stomach activity. Researchers will use MRI scans to measure these effects in healthy adults and people with stomach discomfort. The goal is to better understand how the brain and…

This study looks at whether women with functional dyspepsia (a condition causing stomach pain and discomfort without a clear cause) have different body composition than healthy women. Researchers will use a simple, non-invasive test called bio-electrical impedance to measure fat …