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Dyspepsia
MONDO:0002268An uncomfortable, often painful feeling in the stomach, resulting from impaired digestion. Symptoms include burning stomach pain, bloating, heartburn, nausea, and vomiting. Causes include gastritis, gastric ulcer, gastroesophageal reflux disease, pancreatic disease, and gallbladder disease.
Also known as: dyspepsia, indigestion, indigestion
86 clinical trials for this condition and its sub-types.
Follow this condition — get notified about new trialsBroader categories
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Stomach bug treatment may relieve chronic gut discomfort
Disease control Not yet recruitingThis study will test whether standard treatment to eliminate H. pylori bacteria can improve ongoing stomach and gut symptoms in 100 adults. Participants will receive antibiotics and acid-reducing medication, and their symptoms will be tracked using a questionnaire. The goal is to…
Sponsor: Amany Usama Ahmed Arafa • Aim: Disease control
Last updated Jun 27, 2026 08:04 UTC
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Could ginger and perilla replace acid pills for stomach trouble?
Symptom relief Not yet recruitingThis study tests whether a dietary supplement made from ginger and perilla (Dispepril®) can improve stomach symptoms in people with functional dyspepsia, a condition causing fullness, bloating, and pain after eating. 400 adults will be randomly assigned to take the supplement alo…
Phase: NA • Sponsor: Liaquat University of Medical & Health Sciences • Aim: Symptom relief
Last updated Jun 27, 2026 14:00 UTC
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Mind over belly: talk therapy may soothe stomach pain
Symptom relief Not yet recruitingThis study looks at whether adding Cognitive Behavioral Therapy (CBT) to standard medical care can reduce stomach symptoms in adults with functional dyspepsia, a condition causing pain or discomfort after eating. About 90 adults aged 18-65 will be randomly assigned to receive eit…
Phase: NA • Sponsor: Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis • Aim: Symptom relief
Last updated Jun 27, 2026 12:32 UTC
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Could digestive enzymes soothe stomach pain?
Symptom relief Not yet recruitingThis study tests whether adding digestive enzymes to standard treatment helps people with functional dyspepsia, a condition causing stomach fullness, pain, and burning. 120 adults will take either enzymes plus standard care or standard care alone for 4 weeks. Researchers will tra…
Phase: PHASE4 • Sponsor: Rakibul Mostafa • Aim: Symptom relief
Last updated Jun 27, 2026 12:32 UTC
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Can gentle electric needles soothe your upset stomach?
Symptom relief Not yet recruitingThis study tests whether electroacupuncture—acupuncture with mild electrical pulses—can safely ease symptoms of functional dyspepsia, a condition causing stomach fullness or pain after eating. About 105 adults aged 18 to 80 will be split into groups receiving needles on the abdom…
Phase: NA • Sponsor: The Third Affiliated hospital of Zhejiang Chinese Medical University • Aim: Symptom relief
Last updated Jun 27, 2026 12:01 UTC
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Which drug wins for stomach pain? new trial pits acotiamide against itopride
Symptom relief Not yet recruitingThis study tests whether acotiamide works better than itopride for people with functional dyspepsia, a condition causing fullness, pain, or burning after meals. About 368 adults will take one of the two pills three times daily for 4 weeks and track their symptoms. The goal is to …
Phase: PHASE4 • Sponsor: Aga Khan University • Aim: Symptom relief
Last updated Jun 27, 2026 09:11 UTC
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Could a daily probiotic soothe your upset stomach?
Symptom relief Not yet recruitingThis study looks at whether a multi-strain probiotic capsule can reduce common digestive issues like bloating, fullness, and stomach pain in adults with functional dyspepsia. Sixty participants will take either the probiotic or a placebo daily for 60 days and report their symptom…
Phase: NA • Sponsor: Nordic Biotic Sp. z o.o. • Aim: Symptom relief
Last updated Jun 27, 2026 08:09 UTC
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App-Based mind therapy tested for Kids' tummy troubles
Symptom relief Not yet recruitingThis study tests whether a mobile app that plays guided imagery sessions can help reduce chronic abdominal pain in children aged 7 to 12. Participants listen to 10-15 minute audio sessions five days a week for eight weeks, alongside their usual care. The goal is to see if this ap…
Phase: NA • Sponsor: Baylor College of Medicine • Aim: Symptom relief
Last updated Jun 27, 2026 07:56 UTC
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Herbal blend STW 5-II could soothe stomach pain without drugs
Symptom relief Not yet recruitingThis study tests whether a herbal medicine called STW 5-II can reduce inflammation in the gut lining and ease symptoms like stomach pain, bloating, and fullness after eating in people with functional dyspepsia. About 100 adults will take either the herbal remedy or a placebo for …
Phase: PHASE4 • Sponsor: Universitaire Ziekenhuizen KU Leuven • Aim: Symptom relief
Last updated Jun 27, 2026 07:52 UTC
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Which pill works best for that stuffed feeling after eating?
Symptom relief Not yet recruitingThis study compares two drugs, acotiamide and itopride, to see which one better relieves symptoms like fullness, bloating, and early fullness after meals in people with postprandial distress syndrome. The trial will include 152 adults aged 18-70 who have been diagnosed using stan…
Phase: PHASE3 • Sponsor: Getz Pharma • Aim: Symptom relief
Last updated Jun 27, 2026 07:51 UTC
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New hope for stomach pain? itopride study launches
Symptom relief Not yet recruitingThis study follows 200 people with functional dyspepsia, a common stomach disorder causing fullness and pain after meals. Participants will take itopride as part of their normal care. Researchers will track symptom changes over 16 weeks to see if the drug helps in real-world sett…
Sponsor: Universitaire Ziekenhuizen KU Leuven • Aim: Symptom relief
Last updated Jun 26, 2026 16:03 UTC
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One-Click autofocus could speed up stomach scopes
Knowledge-focused Not yet recruitingThis study tests a new one-click autofocus system for magnifying endoscopy, which uses computer vision to automatically focus the camera during stomach exams. Researchers will compare it to the standard manual focus method in 93 patients with stomach diseases. The goal is to see …
Phase: NA • Sponsor: Shandong University • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:02 UTC
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AI to predict cancer risk from gut bacteria and scans
Knowledge-focused Not yet recruitingThis study will collect data from 10,000 people undergoing upper endoscopy to build an AI model that predicts the risk of developing stomach or esophageal cancer. Researchers will combine information from endoscopy images, tissue samples, genetics, and gut bacteria. Participants …
Sponsor: National Taiwan University Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:39 UTC
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Mind-Gut connection under the microscope: new study probes emotional toll on digestion
Knowledge-focused Not yet recruitingThis study looks at how emotional state influences the course of functional dyspepsia and irritable bowel syndrome in 150 adults. Participants will fill out questionnaires about their quality of life, mood, and anxiety at the start and after treatment. The goal is to better under…
Sponsor: Center of New Medical Technologies • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:10 UTC
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Blood test and ultrasound may spot dangerous stomach ulcers without a scope
Knowledge-focused Not yet recruitingThis study looks at whether combining a blood test for H. pylori bacteria with a painless stomach ultrasound can predict serious complications from peptic ulcers, like bleeding or a hole in the stomach. Researchers will study 230 adults with stomach symptoms to see if these non-i…
Sponsor: Assiut University • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:00 UTC
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New study to track hidden salt and mineral imbalances in sick kids
Knowledge-focused Not yet recruitingThis study will look at 150 infants and children aged 1 month to 4 years who are admitted to a hospital gastroenterology unit with a gastrointestinal disease. The goal is to find out how common electrolyte disturbances (like low sodium or potassium) are in these children. By meas…
Sponsor: Assiut University • Aim: Knowledge-focused
Last updated Jun 26, 2026 12:41 UTC