Can a probiotic help knock out Hard-to-Treat stomach bugs?
NCT ID NCT07139366
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether adding a probiotic called Saccharomyces boulardii to a standard antibiotic cocktail helps clear Helicobacter pylori infections that didn't respond to earlier treatments. About 1,248 adults who have failed prior H. pylori therapy will be randomly assigned to get either the probiotic plus antibiotics or antibiotics alone for 14 days. The main goal is to see if the probiotic improves eradication rates and reduces side effects.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Saccharomyces boulardii (a probiotic yeast) combined with bismuth, esomeprazole, tetracycline, and furazolidone (antibiotics and acid reducer)
What this could lead to
If it works, this could offer a more effective and safer way to treat H. pylori infections that haven't cleared with previous treatments, reducing the risk of ulcers and stomach cancer.
What could go wrong
This is a Phase 4 trial, so the drugs are already approved, but the probiotic's added benefit is uncertain. Side effects like headache, dizziness, and stomach issues are possible.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Xijing Hosipital of Digestive Disease
RECRUITINGXi'an, Shaanxi, 710032, China
Contact Phone: •••-•••-•••• Email: •••••@•••••