HELICOBACTER PYLORI INFECTION

This study tests two different 14-day treatments for H. pylori, a stomach infection that can cause ulcers. About 240 adults will take either tegoprazan or vonoprazan, both with the antibiotic amoxicillin. The goal is to see if the newer drug, tegoprazan, works as well as vonopraz…

This study tests a 'screen and treat' approach for H. pylori infection in 500 teenagers from three regions of Chile. Half will receive antibiotics to clear the infection, while the other half will not. Researchers will check if treatment reduces signs of stomach damage and change…

This study looks at whether adding bismuth to the usual treatment helps clear H. pylori infection and heal stomach or duodenal ulcers in children. About 80 kids will receive either a standard regimen or one with bismuth for 14 days, followed by additional medication to help the u…

This study compares two 14-day treatments for H. pylori, a stomach infection that can cause ulcers. About 552 people will get either a new triple therapy (bismuth, amoxicillin, vonoprazan) or a standard quadruple therapy. The goal is to see which is more effective and safer, and …

This study tests whether adding a probiotic (Saccharomyces boulardii) to a standard antibiotic cocktail helps clear Helicobacter pylori infection in people whose prior treatment failed. About 1,248 adults who have not responded to earlier therapy will receive either the probiotic…

This study compares a new 10-day treatment using tegoprazan against the standard proton pump inhibitor (PPI) therapy for H. pylori infection in South Korea, where antibiotic resistance is common. About 400 adults with confirmed H. pylori will be randomly assigned to one of the tw…

This study tests a simpler treatment for H. pylori infection, a stomach bug that can cause ulcers. Researchers use a stool test to check if the bacteria are resistant to the antibiotic clarithromycin. If not resistant, patients take a two-drug combination (vonoprazan and clarithr…

This study tests whether choosing antibiotics based on lab tests (personalized) works better than standard antibiotic combinations for people whose H. pylori infection did not clear with first treatment. About 450 adults who failed prior therapy will be randomly assigned to one o…

This study tests two different acid-reducing medicines (P-CAB and PPI) as part of a four-drug treatment for H. pylori, a stomach infection. About 320 adults who have not been treated before will take one of the two combinations. The goal is to see which approach kills the bacteri…

This study tests whether a newer drug (vonoprazan) works better than a standard drug (esomeprazole) when combined with two antibiotics to treat H. pylori infection. About 80 adults with stomach discomfort and confirmed H. pylori will take one of the two treatments for 14 days. Fo…

This study looks at 2,600 adults who have had a heart attack, received stents, and also have an H. pylori stomach infection. These patients take blood thinners that raise their risk of stomach bleeding. The trial compares a new drug (vonoprazan plus amoxicillin) against a standar…

This study tests a new method to treat H. pylori, a stomach infection, during an endoscopy. The stomach is filled with a saltwater solution that is treated with a special gas (argon plasma) to kill the bacteria. The study involves 20 adults with untreated H. pylori and compares t…

This study is comparing several different 4-drug treatment combinations to see which works best for eliminating Helicobacter pylori, a common stomach bacteria. It will enroll about 1,730 adults with the infection to track how well each treatment clears the bacteria and what side …

This study looks at whether taking proton pump inhibitors (PPIs), common acid-reducing drugs, changes the accuracy of a stool DNA test for H. pylori infection. Researchers will test 25 adults who need long-term PPI therapy, comparing stool DNA test results while on PPIs and after…

This study follows 600 people at higher risk for stomach cancer to learn how precancerous changes in the stomach lining progress or reverse over time. Participants are adults aged 35-84 having an endoscopy for reasons like stomach pain or a family history of stomach cancer. Resea…