HELICOBACTER PYLORI INFECTION

This study tests two 14-day treatments to cure Helicobacter pylori, a stomach infection that can cause ulcers and cancer. About 240 adults will take either tegoprazan or vonoprazan, both combined with the antibiotic amoxicillin. The goal is to see if the newer drug, tegoprazan, w…

This study tests two different acid-reducing medicines (P-CAB and PPI) as part of a four-drug treatment for H. pylori, a stomach infection. About 320 adults who have not been treated before will take one of the two combinations. The goal is to see which approach kills the bacteri…

This study compares two 14-day treatments for H. pylori, a bacteria that can cause stomach ulcers and cancer. About 552 infected adults will get either a new triple therapy (bismuth, amoxicillin, vonoprazan) or the standard quadruple therapy. Researchers will check which treatmen…

This study looks at 2,600 adults who have had a heart attack, received stents, and also have an H. pylori stomach infection. These patients take blood thinners that raise their risk of stomach bleeding. The trial compares a new drug (vonoprazan plus amoxicillin) against a standar…

This study looks at whether adding bismuth to standard treatment helps clear H. pylori infection and heal stomach or duodenal ulcers in children. About 80 kids will take either a treatment with bismuth or one without. Researchers will check which group has better infection cleara…

This study tests whether a treatment tailored to the specific antibiotic resistance of a person's H. pylori bacteria works better than standard guideline-recommended therapy for people whose first treatment failed. About 450 adults with persistent H. pylori infection will be rand…

This study tests a new method to treat H. pylori, a stomach infection, during an endoscopy. The stomach is filled with a saltwater solution that is treated with a special gas (argon plasma) to kill the bacteria. The study involves 20 adults with untreated H. pylori and compares t…

This study tests whether a newer acid-reducing drug (vonoprazan) works better than a standard one (esomeprazole) for clearing H. pylori infection. About 80 adults with stomach discomfort will take one of the two treatments for 14 days. Four weeks later, a stool test checks if the…

This study tests whether adding a probiotic (Saccharomyces boulardii) to a standard 4-drug antibiotic treatment can better clear H. pylori infection in people whose previous treatment failed. About 1,248 adults who still have the infection after prior therapy will receive either …

This study tests a simpler treatment for Helicobacter pylori infection, a bacteria that can cause stomach ulcers. Researchers will use a stool test to check if the bacteria have a gene that makes them resistant to the antibiotic clarithromycin. If no resistance is found, patients…

This study compares two 10-day treatments for Helicobacter pylori infection, a stomach bug that can cause ulcers and cancer. Researchers want to see if a newer drug (tegoprazan) works better than standard proton pump inhibitors when combined with antibiotics. The trial will enrol…

This study aims to see if finding and treating H. pylori infection in teenagers can reduce their future risk of stomach cancer. About 500 teens in Chile will be screened, and those with persistent infection will be randomly assigned to receive antibiotics or no treatment. Researc…

This study is comparing several different 4-drug treatment combinations to see which works best for eliminating Helicobacter pylori, a common stomach bacteria. It will enroll about 1,730 adults with the infection to track how well each treatment clears the bacteria and what side …

This study follows 600 people at higher risk for stomach cancer to learn how precancerous changes in the stomach lining progress or reverse over time. Participants are adults aged 35-84 having an endoscopy for reasons like stomach pain or a family history of stomach cancer. Resea…

This study looks at whether taking common acid-reducing drugs (proton pump inhibitors, or PPIs) changes the accuracy of a stool DNA test for H. pylori infection. About 25 adults who need long-term PPI treatment will provide stool and stomach samples while on the drug and again af…