DYSPEPSIA

This study tests whether a newer acid-reducing drug (vonoprazan) works better than a standard one (esomeprazole) for clearing H. pylori infection. About 80 adults with stomach discomfort will take one of the two treatments for 14 days. Four weeks later, a stool test checks if the…

This study tests whether adding a probiotic (Saccharomyces boulardii) to a standard 4-drug antibiotic treatment can better clear H. pylori infection in people whose previous treatment failed. About 1,248 adults who still have the infection after prior therapy will receive either …

This study tests domperidone, a drug that helps the stomach empty food faster, in 200 people with chronic digestive problems like gastroparesis, severe heartburn, or indigestion. Participants have already tried standard treatments without success. The goal is to see if domperidon…

This study explores whether a non-invasive nerve stimulation on the ear (taVNS) can improve stomach function and brain responses in people with functional dyspepsia or gastroparesis. Researchers will use brain scans and stomach activity measurements to see how the treatment works…

This study tests whether a drink made from Chios mastic, a natural resin, can help adults with dyspepsia (persistent stomach discomfort). 60 participants will drink either a mastic-enriched carbonated beverage or a placebo daily for 3 months. Researchers will track changes in sym…

This study tests a type of talking therapy (exposure-based CBT) for adults who have both functional dyspepsia (stomach pain or fullness after eating) and avoidant/restrictive food intake disorder (ARFID) with weight loss. The goal is to see if the therapy helps people eat more co…

This study tests a simple, drug-free biofeedback technique to reduce visible belly bloating in people with Irritable Bowel Syndrome (IBS) or similar conditions. One hundred adults who experience bloating after meals will be randomly assigned to learn the technique or receive a pl…

This study is for adults who are already scheduled for a routine throat scope (gastroscopy). Researchers want to find out if having a small patch of stomach-like tissue in the upper esophagus (called heterotopic gastric mucosa) is linked to swallowing difficulties, indigestion, a…

This study aims to collect medical information and biological samples (like blood, urine, and stool) from 2000 adults with functional digestive disorders such as irritable bowel syndrome, dyspepsia, and constipation. The goal is to identify markers that could help diagnose these …

This study looks at how much carbon dioxide is produced during upper GI endoscopy procedures. Researchers will compare the carbon footprint of diagnostic endoscopy for indigestion versus therapeutic endoscopy for stomach bleeding. About 75 adults aged 20-80 will take part, and no…