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New pill aims to calm stomach paralysis nausea

NCT ID NCT06899217

Symptom relief Sponsor: CinDome Pharma, Inc. Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jul 14, 2026 · Updated 3 times

Summary

This Phase 2 trial tests whether CIN-102 (deudomperidone) can reduce nausea in adults with idiopathic gastroparesis, a condition where the stomach empties slowly. Over 400 participants will take either 10 mg, 15 mg, or a placebo twice daily for 12 weeks. Researchers will track symptom changes using daily diaries and a gastric emptying breath test.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Deudomperidone (CIN-102)
What this could lead to
If it works, this could lead to a new treatment option that reduces nausea and other symptoms for people with idiopathic gastroparesis.
What could go wrong
This is a Phase 2 trial, so results are still early. The drug may not prove more effective than placebo, and side effects are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

416 people

The number who actually took part.

Started

Jan 2025

Finished

May 2026

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Key Inclusion Criteria: * Is a male or female ≥18 years of age; * Has a current diagnosis of gastroparesis defined by the following: 1. Persistent gastrointestinal (GI) symptoms that, in the opinion of the Investigator, are consistent with gastroparesis within 6 months prior to Screening; and 2. Documented delayed gastric emptying as determined by gastric emptying breath test (GEBT) at Visit 2. * Body mass index between 17 and 49 kg/m2, inclusive; * If receiving treatment with a Food and Drug Administration (FDA)-approved and marketed glucagon-like peptide-1 receptor agonist (GLP-1RA) for weight loss or reduce risk of major adverse cardiovascular events, and/or, receiving any other agent(s) taken for weight loss, subjects may be considered for the study if ALL of the following criteria are satisfied: 1. Is not taking the agent(s) for the management of diabetes or blood glucose; 2. Has been on a stable dose of the agent(s) for at least 3 months before Screening and is expected to maintain the same dose throughout the study, including during GEBT; 3. Is tolerating the agent(s) well, according to the Investigator's judgment; 4. In the opinion of the Investigator, the study-qualifying signs/symptoms of gastroparesis are NOT solely due to the the agent(s); and 5. Symptoms of gastroparesis were present before starting the agent(s). \------------------------------------------------------------------------- Key Exclusion Criteria: * Has a known primary cause of gastroparesis (eg, diabetes, surgery; acute, ongoing, or active viral illness; cancer, medications, musculoskeletal or connective tissue disorders \[eg, scleroderma, systemic lupus erythematosus\], or other neurologic disorder \[eg, Parkinson's disease\], postural orthostatic tachycardia syndrome (POTS), etc.\]); * Has a current diagnosis of Type 1 or Type 2 diabetes, according to the American Diabetes Association. Pre-diabetes is not exclusionary; * Has been hospitalized for gastroparesis or malnutrition within 3 months prior to Screening; * Has a known or suspected GI mechanical obstruction (eg, peptic stricture) as documented by upper GI endoscopy, upper GI radiographic series, plain film abdomen X-ray, or computed tomography (CT) in the past 2 years prior to Randomization; * Has a history of pyloric injection of botulinum toxin within 6 months of Screening or planned injection(s) during the study; * Has any history of pyloroplasty, pyloromyotomy, or gastric peroral endoscopic myotomy (G-POEM) procedure; * Has a history of gastric surgery; * Has a history of or current diagnosis of intestinal malabsorption, recurrent or chronic pancreatitis, or other pancreatic exocrine disease; * Has a history of severe and refractory constipation; * Has a history or evidence of clinically significant arrhythmia; * Currently receiving parenteral feeding or presence of a nasogastric or other gastric enteral tube (e.g. percutaneous endoscopic gastrostomy \[PEG\] or percutaneous endoscopic jejunostomy \[PEJ\] tube) for feeding or decompression; Note: patients receiving enteral feeding via a jejunostomy tube may be included if, in the opinion of the Investigator, the patient is also taking substantial oral solid intake and are not primarily dependent on enteral nutrition * Has a substance use disorder or a positive alcohol or positive drug screen.

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Conditions

The condition(s) this trial relates to.

Abdominal Pain gastroparesis idiopathic gastroparesis Nausea Vomiting

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Idiopathic gastroparesis

Contacts and locations

Locations

  • Aa Mrc, Llc

    Flint, Michigan, 48504, United States

  • Acclaim Clinical Research

    San Diego, California, 92120, United States

  • Advanced Medical Research Group

    Hollywood, Florida, 33021, United States

  • Advanced Research Institute - Ogden

    Ogden, Utah, 84405, United States

  • Advanced Research Institute - Portland

    Portland, Oregon, 97223, United States

  • Advanced Research Institute - Reno

    Reno, Nevada, 89511, United States

  • Advanced Research Institute - Sandy

    Sandy City, Utah, 84092, United States

  • Advanced Research Institute Inc

    New Port Richey, Florida, 34653, United States

  • Advocate Aurora Health Research Institute

    Milwaukee, Wisconsin, 53215, United States

  • Allied Biomedical Research Institute, Inc.

    Miami, Florida, 33155, United States

  • American Family Research Group

    Cape Coral, Florida, 33909, United States

  • Amir A Hassan, MD, PA

    Houston, Texas, 77089, United States

  • Applied Research Center of Arkansas, Inc

    Little Rock, Arkansas, 72205, United States

  • Atrium Health - Center for Gastroenterology and Hepatology MMP

    Charlotte, North Carolina, 28204, United States

  • Bandera Family HealthCare Research, LLC (BFHC)

    San Antonio, Texas, 78249, United States

  • Capital Digestive Care - Chevy Chase Clinical Research

    Chevy Chase, Maryland, 20815, United States

  • Capital Digestive Center

    Norfolk, Virginia, 23502, United States

  • Carle Clinic - Urbana Main

    Urbana, Illinois, 61801, United States

  • Carolina Digestive Diseases & Endoscopy Center

    Greenville, North Carolina, 27834, United States

  • Connecticut Clinical Research Institute, LLC

    Bristol, Connecticut, 06010, United States

  • Cross Creek Medical Clinic, PA

    Fayetteville, North Carolina, 28304, United States

  • Del Sol Research Management, LLC

    Tucson, Arizona, 85715, United States

  • DelRicht Clinical Research - Atlanta

    Atlanta, Georgia, 30329, United States

  • Delta Research Partners of West Monroe, LLC

    Monroe, Louisiana, 71201, United States

  • Digestive Disease Specialists

    Las Vegas, Nevada, 89128, United States

  • Digestive Health - UT Health Austin

    Austin, Texas, 78712, United States

  • Downtown L.A. Research Center, Inc.

    Los Angeles, California, 90017, United States

  • ENCORE Borland Groover Clinical Research

    Jacksonville, Florida, 32256, United States

  • EPIC Medical Research

    DeSoto, Texas, 75115, United States

  • Epic Clinical Research

    Lewisville, Texas, 75057, United States

  • Erick H. Alayo Medical Corporation

    Chula Vista, California, 91910, United States

  • Excel Clinical Research

    Las Vegas, Nevada, 89109, United States

  • Flourish Research - Los Angeles (Covina)

    Covina, California, 91723, United States

  • Focus Clinical Research - West Hills

    West Hills, California, 91307, United States

  • Frontier Clinical Research, LLC - Smithfield

    Smithfield, Pennsylvania, 15478, United States

  • G & L Research, LLC

    Foley, Alabama, 36535, United States

  • GCP Research

    St. Petersburg, Florida, 33705, United States

  • GI Alliance - Gurnee

    Gurnee, Illinois, 60031, United States

  • GI Alliance - Texas Digestive Disease Consultants - San Marcos

    San Marcos, Texas, 78666, United States

  • Galen Medical Group

    Hixson, Tennessee, 37343, United States

  • Gastro Care Institute

    Lancaster, California, 93534, United States

  • Gastro Health - Birmingham

    Birmingham, Alabama, 35235, United States

  • Gastro Health - Framingham

    Framingham, Massachusetts, 01702, United States

  • Gastro Intestinal Research Institute of Northern Ohio, LLC

    Westlake, Ohio, 44145, United States

  • Gastrointestinal Associates and Endoscopy Center, PA - Flowood

    Flowood, Mississippi, 39232, United States

  • Gastrointestinal Specialists of Georgia PC

    Marietta, Georgia, 30060, United States

  • Hometown Urgent Care and Research (Cincinnati)

    Cincinnati, Ohio, 45150, United States

  • Hometown Urgent Care and Research - Huber Heights

    Huber Heights, Ohio, 45424, United States

  • Hope Clinical Research LLC

    Canoga Park, California, 91303, United States

  • Huron Gastroenterology

    Ypsilanti, Michigan, 48197, United States

  • Integrated Clinical Trial Services, Inc

    West Des Moines, Iowa, 50265, United States

  • KAD Clinical Research, LLC

    St Louis, Missouri, 63123, United States

  • Kansas Medical Clinic, P.A.

    Topeka, Kansas, 66606, United States

  • Manassas Clinical Research Center

    Manassas, Virginia, 20110, United States

  • NOLA Research Works

    New Orleans, Louisiana, 70125, United States

  • NY Scientific

    Brooklyn, New York, 11235, United States

  • Nature Coast Clinical Research

    Inverness, Florida, 34452, United States

  • North Hills Medical Research Inc. (North Hills Family Medicine)

    North Richland Hills, Texas, 76180, United States

  • Options Health Research

    Tulsa, Oklahoma, 74104, United States

  • PPCP Division of Gastroenterology

    Summerville, South Carolina, 29486, United States

  • Paradigm Research - Wheatridge

    Wheat Ridge, Colorado, 80033, United States

  • Peters Medical Research

    High Point, North Carolina, 27260, United States

  • Pioneer Research Solutions Inc.

    Houston, Texas, 77099, United States

  • Portland Gastroenterology Associates

    Portland, Maine, 04101, United States

  • Preferred Research Partners, Inc.

    Little Rock, Arkansas, 72211, United States

  • Quality Clinical Research, Inc

    Omaha, Nebraska, 68114, United States

  • Rocky Mountain Gastroenterology (RMG)

    Lakewood, Colorado, 80228, United States

  • Sanmora Bespoke: Parkway Medical Association

    Glen Burnie, Maryland, 21061, United States

  • Sensible Healthcare, LLC

    Ocoee, Florida, 34761, United States

  • Southwest Gastroenterology Associates

    Albuquerque, New Mexico, 87109, United States

  • St. Charles Clinical Research

    Weldon Spring, Missouri, 63304, United States

  • Summit Clinical Research, LLC

    Athens, Georgia, 30607, United States

  • Susquehanna Research Group, LLC

    Harrisburg, Pennsylvania, 17110, United States

  • Tandem Clinical Research

    Marrero, Louisiana, 70072, United States

  • Temple University Hospital

    Philadelphia, Pennsylvania, 19140, United States

  • Texas Digestive Specialists

    Texas City, Texas, 78550, United States

  • The Center for Clinical Trials

    Saraland, Alabama, 36571, United States

  • Treasure Valley Medical Research

    Boise, Idaho, 83706, United States

  • USA and International Research Inc.

    Doral, Florida, 33126, United States

  • Unique Clinical Trials

    Doral, Florida, 33172, United States

  • University of Colorado Anschutz

    Aurora, Colorado, 80045, United States

  • University of Louisville

    Louisville, Kentucky, 40202, United States

  • Urgent Care Specialists, LLC DBA Hometown Urgent Care and Occupational Health - Columbus

    Columbus, Ohio, 43228, United States

  • Westchester Putnam Gastro

    Carmel, New York, 10512, United States

  • Zenos Clinical Research

    Dallas, Texas, 75230, United States

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