Brain zap tunes heart and gut: new hope for depression?
NCT ID NCT06748274
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This completed study tested whether noninvasive brain stimulation can be personalized by measuring heart rate responses. Researchers mapped the scalp to find the best spot for stimulation in 34 healthy participants and people with depression, anxiety, and gut issues. They compared two techniques—TMS and tDCS—and measured heart, gut, and sweat responses. The goal is to make depression treatment more effective and accessible.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Transcranial Magnetic Stimulation (TMS) and High-definition transcranial direct current stimulation (HD-tDCS)
What this could lead to
If successful, this could lead to more personalized and effective brain stimulation treatments for depression by targeting the right spot on the scalp.
What could go wrong
This is a small, early-stage study in healthy volunteers and a few people with symptoms. The approach may not work in larger, more diverse groups or improve depression outcomes.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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University Hospital of Old Age Psychiatry and Psychotherapy Bern
Bern, Canton of Bern, 3000, Switzerland