Brain scans may guide psychedelics and magnetic pulses to quell suicidal thoughts

NCT ID NCT07745569

Not yet recruiting Disease control Sponsor: University of New Mexico Source: ClinicalTrials.gov ↗

First seen Aug 04, 2026 · Last updated Aug 05, 2026 · Updated 1 time

Summary

This trial explores whether personalized brain imaging can predict who responds best to three rapid-acting treatments for suicidal ideation in people with depression or PTSD. Participants receive either real-time brain feedback (neurofeedback), a form of magnetic brain stimulation called TMS, or psilocybin-assisted therapy. The goal is to see if these therapies can reduce suicidal thoughts and change activity in key brain networks, potentially leading to more precise, effective treatments.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Transcranial magnetic stimulation (TMS), neurofeedback, and psilocybin-assisted therapy
What this could lead to: If successful, this could lead to personalized, brain-guided treatments that rapidly reduce suicidal thoughts in people with depression and PTSD.
What could go wrong: This is an early-phase trial with a small number of participants, so results may not apply broadly. The therapies carry risks, including psychological distress and side effects, and may not work for everyone.

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Conditions

The condition(s) this trial relates to.

combat disorder major depressive disorder post-traumatic stress disorder Suicidal Ideation

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MAJOR DEPRESSION PTSD PTSD - POST TRAUMATIC STRESS DISORDER SUICIDALITY

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