PTSD

This study tests a therapy toolkit called Signs of Safety, designed for Deaf individuals who use American Sign Language and struggle with alcohol use disorder and PTSD. The toolkit adapts an existing therapy (Seeking Safety) to be Deaf-accessible. Researchers compare it to treatm…

This Phase 2 trial is testing whether HB-1, a tablet combining two blood pressure medications (telmisartan and verapamil), can safely reduce PTSD symptoms. About 200 adults aged 18-65 with PTSD will receive either HB-1 or a placebo daily for 12 weeks. The main goal is to see if H…

This study tests a combined therapy for mothers with PTSD who are already receiving child welfare prevention services. The treatment blends skills to manage emotions and trauma with parent-child interaction coaching. Researchers will track changes in PTSD, depression, parenting b…

This study tests a program called HARPP that combines proven treatments for PTSD and weight management into a single therapy for veterans. The goal is to see if this integrated approach leads to greater weight loss and PTSD symptom reduction compared to standard care. The study w…

This study tests whether reducing PTSD symptoms can prevent acute pain from turning into chronic pain. Researchers will give 345 adults either a nerve block injection (stellate ganglion block) or trauma-focused talk therapy (cognitive processing therapy). The goal is to see if th…

This study is creating and testing short videos for teens (ages 12-17) and their parents after a traumatic injury that requires a hospital stay. The goal is to prevent posttraumatic stress disorder (PTSD) and substance use. The videos will be developed with input from families an…

This study tests whether a short form of exposure therapy, given soon after a traumatic injury, can prevent posttraumatic stress disorder (PTSD). Researchers will enroll 300 injured adults admitted to Level I trauma centers. Half will receive the brief therapy plus standard care,…

This study tests whether a drug called psilocybin (the active ingredient in magic mushrooms) combined with therapy can help women with PTSD from sexual assault. About 70 women will receive the treatment in a controlled setting. The goal is to see if it reduces PTSD symptoms and i…

This trial tests whether starting PTSD treatment with one type of talk therapy and then switching to another based on early progress leads to better symptom relief. About 430 adults receiving care at federally qualified health centers will take part. The study compares different …

This study tests whether adding a crisis response plan (CRP) to prolonged exposure (PE) therapy helps reduce suicidal thoughts and behaviors in people with PTSD. Researchers will compare PE plus CRP to PE with standard care in 100 adults. The goal is to find a better way to suppo…

This study tests whether a single dose of psilocybin (the active ingredient in magic mushrooms) combined with intensive therapy can help people with chronic posttraumatic stress disorder (PTSD). Fifteen adults with moderate to severe PTSD will receive the treatment over a week. T…

This study tests whether answering a short daily survey about a specific traumatic memory can reduce the intensity and frequency of intrusive PTSD symptoms. Fifty adults with PTSD will either complete surveys about their trauma memory or about a neutral memory for 10 days. Resear…

This study tests a hybrid dialectical behavior therapy (DBT) program for veterans with PTSD who have already completed inpatient treatment. The goal is to reduce lingering symptoms and prevent relapse. About 24 veterans will take part, combining in-person skill groups with online…

This study tests a program called Parenting STAIR Modular (PSTAIR-M) for military-connected mothers who have experienced trauma and have young children aged 2-10. The program helps mothers manage PTSD and depression symptoms while improving their parenting skills. Researchers wil…

This pilot study is testing a 12-session virtual therapy that combines two proven treatments—one for PTSD and one for chronic pain—into a single program. Researchers want to see if this integrated approach is feasible and acceptable for adults who suffer from both conditions. The…

This study tests whether adding a nerve block injection (stellate ganglion block) to standard talk therapy (cognitive processing therapy) helps reduce PTSD symptoms more than either treatment alone. About 270 adults with PTSD will be assigned to one of three groups: combination t…

This study tests whether a short, evidence-based therapy for PTSD (Written Exposure Therapy) can be effectively delivered by community health workers to pregnant women. The goal is to make treatment more accessible and reduce PTSD symptoms during pregnancy and after childbirth. A…

This early-stage trial tests whether giving psilocybin (the active ingredient in magic mushrooms) in a group setting is safe and feasible for people with PTSD. 36 participants, including veterans, first responders, and survivors of sexual violence, will receive two group dosing s…

This study tests whether a simple injection of dextrose (sugar water) into the neck can reduce symptoms like anxiety, brain fog, and depression in people with PTSD who haven't improved after trying multiple medications and therapies. About 50 adults will receive either the dextro…

This study tests if trauma-adapted yoga, added to usual care, can improve mental health and quality of life for 180 teens diagnosed with ADHD or PTSD. Participants will be randomly assigned to a yoga group or a waiting list. The study also explores if online yoga is a feasible op…

This study tests a handheld device called gammaCore that gently stimulates the vagus nerve in the neck, aiming to reduce PTSD symptoms. About 40 adults with PTSD will use the device at home for 12 weeks. Researchers will track symptom changes and safety to see if this approach co…

This study tests whether adding booster sessions and homework reminders to a short psychological program (PM+) can further reduce stress, PTSD, and other mental health problems in refugees and asylum seekers. About 1,200 participants in Switzerland will receive the enhanced suppo…

This study looks at whether different levels of exercise can help people with PTSD remember fear-reduction lessons better. 200 adults with PTSD will do a 3-day fear learning and extinction task, then either rest or do light, moderate, or high-intensity exercise. The goal is to se…

This study tests a treatment called SMART, which uses movement and body awareness to help adults with PTSD. 80 participants will attend 8 sessions and be assessed before, after, and 3 months later. The goal is to see if this approach reduces PTSD symptoms and improves body awaren…

This study tests whether a special type of sleep therapy, adapted for trauma, can help women veterans with both insomnia and PTSD feel more ready to engage in PTSD treatment. About 100 women veterans will be randomly assigned to either the sleep therapy or a general education pro…

This study tests a new, single-session therapy called PATH-SS for people struggling with PTSD or depression after a sexual assault. Researchers want to see if this brief treatment reduces distress and is helpful to participants. The study involves 45 adults in Ohio who experience…

This study compares two types of talk therapy for PTSD caused by military sexual trauma: exposure therapy and interpersonal therapy. Researchers want to see if interpersonal therapy works just as well as exposure therapy, which could give survivors more options. The trial will en…

This study aims to find out which parts of behavioral therapy work best for children aged 8-17 with PTSD after a traumatic event. Researchers will compare different therapy components, like emotion regulation and exposure, to a placebo. 200 children and their caregivers will part…

This study tests whether a low dose of clonidine, a drug usually used for high blood pressure, can improve sleep and reduce PTSD symptoms in veterans. About 32 veterans with PTSD will take a flexible dose of clonidine nightly for 6 weeks. Researchers will track changes in sleep q…

This study tests whether adding special memory-support techniques to a standard PTSD therapy (Cognitive Processing Therapy) helps veterans learn and remember the therapy content better. About 100 adults with PTSD will take part. The goal is to see if better memory of therapy lead…

This study tests a nerve block procedure called bilateral cervical sympathetic block (BCSB) in 75 Special Operations Veterans with PTSD, anxiety, or traumatic brain injury. The procedure uses a numbing medicine to calm overactive nerves. Some participants also receive talk therap…

This study tests a 6-session psychoeducation program for people who have experienced sexual violence. The goal is to see if the program improves their quality of life, self-esteem, and mental well-being. Researchers will enroll 60 participants from a hospital clinic in France.

This early-stage study at Yale is testing whether a single 25 mg dose of psilocybin is safe and tolerable for people whose daily life is impaired by mood, anxiety, trauma, or addiction symptoms. Fifty participants will receive the drug openly (everyone knows they get it) and be f…

This study tests a special mental health program for people who have been in the ICU. It includes coaching, digital tools, and psychiatric support to help with anxiety, depression, and PTSD. The goal is to see if this program works better than usual care. About 150 adults who vis…

This study tests whether group-based MDMA-assisted therapy works as well as individual sessions for people with PTSD linked to the October 7, 2023 events. 168 participants will receive MDMA in either a group or individual setting, along with therapy sessions. The goal is to see i…

This pilot study tests a behavioral health program designed to support family members of ICU survivors. The program includes telehealth check-ins and a digital platform to track mood and stress. Researchers want to see if this approach is practical and helpful for reducing anxiet…

This early-stage study tests whether psilocybin from whole mushrooms can safely help adults with PTSD. Up to 24 participants will eat dried mushrooms in chocolate and be monitored for side effects and symptom changes. The goal is to gather safety data and see if this approach mig…

This study tests a new type of talk therapy for veterans and service members who have both PTSD and a mild or moderate traumatic brain injury. The therapy focuses on relaxation, stress management, and problem solving instead of asking patients to relive their trauma. The goal is …

This pilot study tests a 12-week workshop called STEP-Home-SP for veterans who recently left military service. The workshop teaches emotional regulation and problem-solving skills to help with reintegration and reduce suicide risk. Researchers will enroll 120 veterans to see if t…

This Stanford study tests whether having a dream while under anesthesia can reduce PTSD symptoms. In a small Phase 2 trial, 42 adults with PTSD will receive either deep sedation to trigger dreaming or light sedation without dreaming. Researchers will compare changes in PTSD sever…

This pilot study tests a new 12-week group therapy program called BEAR-SI for women aged 18-75 who have experienced interpersonal trauma and currently have suicidal thoughts. The program combines psychological skills, education about trauma, and physical self-defense training. Th…

This study tests an internet-based therapy called acceptance and commitment therapy (iACT) for people with both PTSD and chronic pain. Forty adults will either receive the therapy immediately or join a waitlist. The program includes mindfulness, value-based exercises, and written…

This study tests a therapy called Targeted Cognitive Training (TCT) for veterans with serious mental illnesses like schizophrenia, bipolar disorder, or PTSD. The goal is to improve thinking skills and daily functioning by using EEG brain scans to identify who will benefit most. A…

This study tests whether Cognitive Processing Therapy (CPT), a talk therapy used in the community, can reduce PTSD symptoms and rule-breaking in incarcerated men and women. About 900 participants from 6 prisons will attend 8–12 therapy sessions over up to 24 weeks. Researchers wi…

This study tests a 12-week group therapy program called ECCCLORE for people who have both post-traumatic stress disorder (PTSD) and addiction. The program combines skills for managing emotions, distress, and relationships. Researchers want to see if it is feasible and acceptable …

This study tests a drug called CORT108297, which blocks the stress hormone cortisol, as a short-term treatment for PTSD in veterans. Forty veterans with PTSD will take either the drug or a placebo daily for one week. The goal is to see if it reduces PTSD symptoms and to check its…

This study tests whether adding augmented reality (AR) to standard exposure therapy helps U.S. military personnel with PTSD more than therapy alone. Forty veterans or active-duty members will be split into two groups: one gets traditional therapy plus AR, the other gets therapy o…

This study tests whether a guided therapy using psilocybin (the active ingredient in magic mushrooms) can safely help US Veterans with PTSD. Fifteen participants will receive two psilocybin sessions combined with talk therapy. The goal is to reduce PTSD symptoms and improve long-…

This study looks at whether art therapy can help active-duty military and recent veterans who have PTSD symptoms. Forty participants will attend 11 sessions over 6-8 months, including art therapy with a certified therapist and two MRI brain scans. The goal is to see if art therap…

This study tests whether a smartphone app called OTX-601 can help reduce symptoms of post-traumatic stress disorder (PTSD) in adults. Forty people with PTSD will use either the active app or a placebo version for several weeks. Researchers will track changes in PTSD symptoms usin…

This study compares a new type of therapy that combines computer exercises with therapist sessions (blended CBT) to standard prolonged exposure therapy for PTSD. About 160 adults with PTSD will receive one of the two treatments at outpatient clinics in Sweden. The goal is to see …

This study is testing whether a type of talk therapy called metacognitive therapy (MCT) can be delivered in a group setting for people with post-traumatic stress disorder (PTSD) in regular psychiatric care. The goal is to see if it is practical and acceptable to patients, and to …

This study aims to find the best strategies for veterans with PTSD who aren't helped by their first treatment. Researchers will test a flexible version of Cognitive Processing Therapy and text message reminders to encourage homework completion. The goal is to match the right type…

This study is creating and testing a short, online therapy program for LGBTQ+ people who have experienced trauma and drink alcohol. In the first phase, participants share their thoughts to make the program more helpful and welcoming. In the second phase, some participants can try…

This study tests a type of talk therapy called Trauma-Focused Psychodynamic Psychotherapy (TFPP) for veterans with PTSD who haven't gotten better with standard VA treatments. About 75 veterans will be randomly assigned to receive either TFPP or usual care. The goal is to see if T…

This study tests a non-invasive device that stimulates the vagus nerve (a key nerve in the body) to see if it can improve memory and reduce PTSD symptoms in veterans with mild traumatic brain injury. One hundred veterans will receive either active stimulation or a sham (fake) tre…

This study compares two ways of delivering a combined attention and strategy training program to veterans with mild traumatic brain injury and PTSD. One group receives the training in person, the other via telehealth. The goal is to see if remote delivery works just as well for i…

This study tests a 1-month self-management program for people who have recently received a shock from their implantable defibrillator (ICD). The program includes heart rate monitoring and online modules with phone coaching, aiming to reduce anxiety and prevent PTSD. 60 participan…

This study tests a specific type of acupuncture, called 'External and Internal Dragons,' to see if it can reduce PTSD symptoms in military members and their families. The treatment is designed to help the rational and emotional parts of the brain communicate better, so the emotio…

This study tests whether a daily nasal spray of insulin can reduce PTSD symptoms. Twenty adults with current PTSD will receive either insulin or a placebo for several weeks. Researchers will measure symptom changes using a standard PTSD scale.

This study tests whether a computer-based working memory training program can help veterans with PTSD improve their ability to unlearn fear responses. 120 veterans will be randomly assigned to either the training or a sham version. The goal is to see if the training changes brain…

This study looks at how a non-invasive brain stimulation technique called TMS affects the brain's fear circuits. Researchers will test different TMS settings in 250 people with and without PTSD to see how it changes fear-related brain activity and skin responses. The goal is to l…

This study looks at how a type of talk therapy called Cognitive Processing Therapy (CPT) changes brain circuits related to reward and pleasure in people with PTSD. Researchers will use brain scans to track these changes in 120 participants. The goal is to understand why some peop…

This observational study at Yale University is recruiting 200 people who are already taking part in another trial where they may receive a serotonergic psychedelic (like psilocybin or LSD) or a placebo. Researchers want to understand how these substances change the brain's inform…

This study is testing whether a prebiotic called resistant potato starch can change the gut microbiome in 30 veterans who have both cirrhosis (liver scarring) and PTSD. Participants will take either the potato starch or a placebo (cellulose) for a period, and researchers will mea…

This study looks at how growing up with a heart condition might increase the risk of post-traumatic stress disorder (PTSD). Researchers will survey 1,000 adults with congenital heart disease to find out which experiences—like past surgeries or bullying—are linked to PTSD. They wi…

This study looks at whether using a short-acting paralytic drug (succinylcholine) instead of a longer-acting one (rocuronium) can prevent patients from being awake while paralyzed during emergency breathing support. About 3,090 adults on ventilators in emergency departments will …

This study looks at whether a single dose of estradiol (a hormone) can reduce the number of intrusive, unwanted memories that form after a traumatic event. Healthy female volunteers will watch a stressful film and then record any intrusive memories over the next four days. The go…

This study looks at how trauma-focused therapy changes brain connections in teenagers with PTSD. Researchers will use brain scans before and after each phase of therapy to understand which brain networks are involved. The goal is to learn how therapy works in the brain, which cou…

This study aims to understand the brain mechanisms behind fear and anxiety in people with anxiety disorders like PTSD and GAD. Researchers will measure brain activity, heart rate, and skin responses while participants view fear-provoking images or use virtual reality. The study i…

This study will use advanced PET/MRI scans to see how exercise affects brain activity and blood vessel inflammation in 10 people with PTSD who also have heart disease or risk factors. Participants will follow a gradually increasing exercise program. The goal is to understand whet…

This study tests a new system to help doctors better screen for and manage PTSD in primary care clinics on Chicago's South Side. About 17,000 adults will take part. The goal is to see if this approach leads to more people being diagnosed and getting the right treatment.

This study compares two different screening methods for PTSD in pregnant Black women to see which one better improves mental health, use of prenatal and mental health care, and birth outcomes. About 804 Black women in their first trimester who have experienced at least one trauma…

This study is testing a program called Coffee and Family Education and Support (CAFES2) for refugee families from Arabic-speaking countries who have recently moved to Chicago. The program is led by trained peers and aims to improve mental health and family relationships. Research…

This study looks at how exercise affects the way people with PTSD learn and remember emotional information. One hundred adults with PTSD from interpersonal violence will do either moderate or light cycling after recalling a traumatic memory. Researchers will measure anxiety, hear…