PTSD

This study tests a mental health support program for adults hospitalized after serious injuries who show signs of PTSD. The program provides personalized care management, therapy, and medication options. Researchers want to see if this approach reduces PTSD symptoms and decreases…

This study is testing whether adding oxytocin, a natural hormone, to a proven therapy can help Veterans who are struggling with both post-traumatic stress disorder (PTSD) and alcohol use disorder. Researchers want to see if oxytocin, given as a nasal spray before weekly therapy s…

This study is creating and testing a brief, online therapy program specifically for LGBTQ+ people who have experienced trauma and struggle with alcohol use. In the first part, participants help design the program to make it relevant and affirming. In the second part, some partici…

This early-stage study is checking if psilocybin mushrooms are safe for adults with PTSD and how the body processes them. 24 participants will take a single dose of dried mushrooms in chocolate form under medical supervision. Researchers will monitor side effects and measure drug…

This study aims to figure out which parts of therapy work best to help children and teenagers recover from post-traumatic stress disorder (PTSD). Researchers will test different combinations of therapy techniques with 200 young participants who have experienced trauma. The goal i…

This study is testing whether group-based MDMA-assisted therapy is as safe and effective as individual therapy for people with PTSD related to the events of October 7, 2023. It will involve 168 participants who will receive the therapy in either a group or individual setting. The…

This study is testing if a special sleep therapy can help women veterans who have both PTSD and insomnia feel more ready to start and stick with PTSD treatment. It will compare a therapy focused on improving sleep habits to a standard educational program. The goal is to see if im…

This study is testing whether a computer-based working memory training program can help Veterans with PTSD better manage fear responses. 120 participants will complete either the real training or a placebo version over four weeks, with brain scans before and after. Researchers wa…

This study is testing whether a group therapy program called Cognitive Processing Therapy (CPT) helps reduce PTSD symptoms and behavioral problems in incarcerated men and women. About 900 participants from 6 prison locations will be randomly assigned to either start therapy immed…

This study is testing a new therapy designed specifically for military veterans and service members who have both post-traumatic stress disorder (PTSD) and a traumatic brain injury. The treatment involves individual counseling sessions that focus on managing PTSD symptoms without…

This study aims to find the best way to screen for PTSD (post-traumatic stress disorder) in Black women during early pregnancy. Researchers will compare two different screening approaches to see which one is more effective at reducing PTSD symptoms and improving pregnancy care. T…

This study is testing a new drug called CORT108297 that blocks the stress hormone cortisol to see if it helps treat PTSD in veterans. About 40 veterans with chronic PTSD will take the drug or a placebo for 7 days. The main goals are to check if the drug is safe and to gather earl…

This study compares two types of talk therapy for people with PTSD from military sexual trauma. Researchers want to see if interpersonal therapy works as well as the more established exposure therapy. The study involves 208 participants and aims to expand effective treatment opti…

This VA study is testing a new, combined treatment program for Veterans who have both PTSD and obesity. The program merges proven mental health therapy with weight management support, including medication reviews. Researchers want to see if this integrated approach helps Veterans…

This study aims to help veterans with PTSD who aren't improving with their first treatment. Researchers will test whether switching to a different therapy approach or using text message reminders for homework assignments works better. The goal is to find the right treatment combi…

This study is testing whether a shorter, 12-week therapy program is practical and acceptable for people dealing with both addiction and trauma (PTSD). The program, called ECCCLORE, teaches skills to manage emotions, tolerate distress, and improve relationships. Researchers will e…

This study is testing whether adding augmented reality (AR) to standard exposure therapy helps military personnel with PTSD. 40 veterans or active-duty members will be randomly assigned to receive either standard therapy alone or therapy enhanced with AR scenarios, like simulated…

This study is testing whether guided psilocybin sessions combined with therapy can safely and effectively treat PTSD in US military veterans. Fifteen veterans will receive two psilocybin sessions alongside psychotherapy. Researchers will measure changes in PTSD symptoms, depressi…

This study is testing a special therapy program for mothers who have PTSD and are involved with child welfare services. It aims to help mothers manage their trauma symptoms and improve their parenting skills, with the goal of reducing the risk of future child maltreatment. The st…

This study is testing if a simple injection of a sugar-water solution (dextrose) around nerves in the neck can help control symptoms of PTSD. It will compare the injection to delayed or usual care in 24 adults who have tried other treatments without enough relief. The main goals …

This study is testing a new blended therapy for post-traumatic stress disorder (PTSD) that combines online computer modules with in-person therapy sessions. Researchers want to see if this new approach works as well as the current gold standard therapy, called Prolonged Exposure.…

This study is testing a new system to help primary care clinics better identify and manage Post-Traumatic Stress Disorder (PTSD). It will involve screening 17,000 adult patients in Chicago clinics, especially in areas with high rates of trauma. The goal is to see if using patient…

This study is testing video programs designed to prevent post-traumatic stress disorder (PTSD) and substance use problems in teenagers who have been seriously injured. Researchers are working with 62 parent-teen pairs at a pediatric trauma center to develop and test these educati…

This study aims to prevent a terrifying experience called 'awareness with paralysis,' where emergency room patients on breathing machines are awake but can't move. It will test if making a shorter-acting paralytic drug the standard choice reduces this risk and lowers rates of PTS…

This study aims to prevent acute pain from developing into long-term chronic pain by treating PTSD symptoms early. Researchers will enroll 345 adults with PTSD who arrive at the emergency room or clinic with new, non-injury pain. Participants will be randomly assigned to receive …

This study is testing whether a brief, three-session therapy can prevent posttraumatic stress disorder (PTSD) in people who have been seriously injured. Researchers will enroll 300 patients admitted to Level 1 trauma centers and randomly assign them to receive either the brief th…

This study is testing a one-month online self-management program designed to help people who have recently received a shock from their implanted heart defibrillator (ICD). The program teaches heart rate monitoring and coping skills through web-based modules, with the goal of redu…

This study is testing a new type of talk therapy called Trauma-Focused Psychodynamic Psychotherapy (TFPP) for veterans with PTSD who haven't gotten better with standard treatments. The therapy focuses on understanding trauma experiences without using exposure techniques. Research…

This study is testing a special online parenting program designed to help military-connected mothers who have experienced trauma. The program aims to help mothers manage difficult emotions like PTSD and depression, and improve their parenting skills and connection with their youn…

This study is testing whether moderate exercise after recalling traumatic memories helps people with PTSD process those memories more effectively. 100 adults with PTSD related to interpersonal violence will recall trauma cues during brain scans, then do either moderate or light e…

This study is testing whether a specific type of group therapy, called Metacognitive Therapy (MCT), is practical and acceptable for treating PTSD in a regular Swedish psychiatric clinic. It will involve about 30 adults with PTSD to see if they can complete the 14-week program and…

This study is testing whether a specific type of acupuncture can help reduce the distressing symptoms of Post-Traumatic Stress Disorder (PTSD). It will involve 75 active-duty military members and their families who have been diagnosed with PTSD. Researchers will measure changes i…

This study is testing whether insulin, a hormone usually used for diabetes, can help reduce symptoms of PTSD when delivered as a nasal spray. It will involve about 20 adults diagnosed with PTSD to see if the treatment lowers their symptom scores and calms overactive brain areas l…

This small pilot study is testing whether a new, combined virtual therapy can help people who suffer from both PTSD and chronic pain. The treatment blends two proven therapies into 12 online sessions to address both conditions at the same time, rather than one after the other. Re…

This study is testing a special group therapy program designed to help people who have experienced sexual violence. The program involves education and support sessions co-led by therapists and a former patient. Researchers want to see if participating improves participants' quali…

This study is looking at whether a medical procedure called a bilateral cervical sympathetic block (BCSB) can help reduce trauma-related symptoms in Special Operations veterans. The procedure involves injecting medication near nerves in the neck to calm the body's stress response…

This study is testing an online therapy program designed to help people who have both PTSD and long-term pain. It will involve 40 participants who will either start the program right away or after a 12-week wait. The goal is to see if this internet-delivered therapy can reduce sy…

This early-stage study from Yale University is testing whether a single dose of psilocybin, the active compound in 'magic mushrooms,' is safe and tolerable for people whose daily lives are impacted by symptoms of depression, anxiety, trauma, or addiction. The study will enroll 50…

This study is testing a new workshop designed to help veterans in their first few years after leaving the military. The goal is to provide skills for civilian life, connect them to VA healthcare, and reduce their risk of suicide. Researchers will enroll 120 veterans to see if the…

This study is testing whether a device that gently stimulates a nerve in the neck can help veterans who have both mild traumatic brain injury (mTBI) and PTSD. Researchers want to see if using the device improves memory and reduces PTSD symptoms. They will measure changes in brain…

This study is testing a new, single-session therapy designed to help college students who are struggling emotionally after experiencing a sexual assault. Researchers want to see if this 2-hour therapy session can reduce symptoms of PTSD and depression. The study will enroll 45 Oh…

This Stanford study is testing whether intentionally inducing dreams while under light anesthesia can help reduce the symptoms of Post-Traumatic Stress Disorder (PTSD). In this Phase 2 trial, 42 adults with PTSD will be randomly assigned to receive either a deep sedation designed…

This study is testing a family support program designed to help refugee families cope with stress, trauma, and mental health challenges. The program brings families together in groups led by fellow refugees to build community support and improve family relationships. Researchers …

This study is testing whether a brain training program that combines strategy coaching with attention exercises can help veterans with mild brain injury and PTSD improve their thinking skills and ability to handle daily tasks. Researchers are comparing whether delivering this tra…

This study is testing a new 12-week group therapy program for women who have experienced interpersonal trauma (like physical or sexual abuse) and are currently having suicidal thoughts. The program combines psychological counseling with physical self-defense training, aiming to b…

This study is testing whether a smartphone app called OTX-601 can help reduce symptoms of post-traumatic stress disorder (PTSD) in adults. Researchers will compare the app against another digital program to see which works better at easing PTSD symptoms over 7 weeks. The study in…

This study is testing a computer-based brain training program for veterans with serious mental illnesses like schizophrenia, bipolar disorder, or PTSD. The goal is to see if this training can improve thinking skills, reduce symptoms, and help with daily life activities. Researche…

This study aims to understand how living with a congenital heart condition affects mental health. Researchers will survey and interview 1,000 adults with congenital heart disease to identify which medical and life experiences increase the risk of developing PTSD. The goal is to l…

This study aims to understand how reducing cannabis use affects the daily lives and functioning of veterans with PTSD. Researchers will observe 40 veterans who currently use cannabis frequently, tracking their use and how they manage daily activities. The goal is to gather real-w…

This study aims to understand how exercise might help people with PTSD who also have a higher risk for heart disease. Researchers will use special PET/MRI scans to look at brain activity and inflammation in blood vessels before and after an exercise program. The goal is to gather…

This study aims to understand how art therapy helps military personnel manage post-traumatic stress symptoms. Researchers will work with 40 active-duty or recently separated veterans who experience significant PTSD symptoms. Participants will attend art therapy sessions and have …

This study is testing if a single dose of the hormone estradiol can help prevent the formation of intrusive, unwanted memories after a stressful experience. Healthy female volunteers will watch a stressful film and then track any upsetting memories that pop up over the next few d…

This study aims to understand how trauma therapy helps teens with PTSD by looking at brain changes. Researchers will scan the brains of 180 teens before and after each phase of therapy to see which parts of the brain change during treatment. The goal is to learn how therapy works…

This study aims to understand how the brain creates feelings of fear and anxiety in people with conditions like PTSD and generalized anxiety. Researchers will measure brain activity, heart rate, and skin responses in 80 participants who already have special brain-monitoring impla…