PTSD

This study tests a program that combines PTSD treatment with weight management for Veterans who have both conditions. The goal is to see if this combined approach helps Veterans lose more weight and reduce PTSD symptoms better than standard care. About 182 Veterans will take part…

This study aims to reduce suicidal thoughts and behaviors in 100 adults with PTSD by combining two proven treatments: prolonged exposure therapy and a crisis response plan. Participants will receive either the combined therapy or prolonged exposure with standard care. The goal is…

This study tests a combined therapy for mothers with PTSD who are at risk of child maltreatment. The treatment blends skills to manage emotions and improve parent-child interactions. Researchers will track changes in PTSD, depression, parenting behaviors, and reports of abuse or …

This study is creating and testing short videos for teens (ages 12-17) and their parents after a serious injury that requires a hospital stay. The goal is to prevent post-traumatic stress disorder (PTSD) and substance use. The videos will be developed with input from families and…

This study tests whether treating PTSD symptoms soon after acute pain starts can stop the pain from becoming chronic. Researchers will use either a nerve block (stellate ganglion block) or talk therapy (Cognitive Processing Therapy) in 345 adults with PTSD and acute pain. The goa…

This study tests whether a brief form of exposure therapy, given soon after a serious injury, can prevent posttraumatic stress disorder (PTSD). Researchers will enroll 300 adults admitted to Level I trauma centers. Participants will be randomly assigned to receive the brief thera…

This study tests a new, single-session therapy called PATH-SS for people struggling with PTSD and depression after a sexual assault. About 45 adults in Ohio who experienced unwanted sexual contact will receive the therapy and be followed for one month. The goal is to see if this …

This study tests if a simple injection of dextrose (sugar water) into the neck can reduce PTSD symptoms like anxiety, brain fog, and depression. About 24 adults who have tried at least two medications and two non-drug treatments for PTSD will receive either the injection or delay…

This study is creating and testing a short, virtual therapy program for LGBTQ+ people who have experienced trauma and use alcohol. In the first part, participants share their thoughts to make the program more helpful and inclusive. In the second part, some participants can try th…

This study tests a treatment called SMART, which uses movement and body awareness to help adults with PTSD. 80 participants will attend 8 sessions and complete assessments before, after, and 3 months later. The goal is to see if this approach reduces PTSD symptoms and improves bo…

This study tests a 12-session skills workshop called STEP-Home-SP for veterans who left the military within the last three years. The goal is to help them reintegrate into civilian life, connect with VA healthcare, and lower suicide risk. About 120 veterans will participate to se…

This study tests whether inducing a dream state during anesthesia can reduce PTSD symptoms. 42 adults with PTSD will be randomly assigned to either deep sedation (designed to produce dreams) or light sedation (designed to produce non-dream experiences). The main goal is to see if…

This study is for veterans who have both mild traumatic brain injury (mTBI) and PTSD. Researchers are testing a non-invasive device that stimulates the vagus nerve (nVNS) to see if it improves memory, reduces PTSD symptoms, and changes brain activity. Participants will use the de…

This study tests whether psilocybin (the active ingredient in magic mushrooms) combined with therapy can safely reduce PTSD symptoms in US Veterans. Fifteen participants will receive two guided sessions plus psychotherapy. The goal is to measure safety and symptom improvement, no…

This study tests a new drug called CORT108297 that blocks the stress hormone cortisol, aiming to reduce PTSD symptoms in veterans. About 40 veterans with PTSD will take the drug or a placebo for several weeks. Researchers will measure symptom changes and side effects to see if th…

This study tests an internet-based therapy for people with both PTSD and long-term pain. About 40 adults will receive the therapy or be placed on a waiting list. The goal is to see if this approach reduces PTSD symptoms and helps people cope better with pain.

This study tests a type of talk therapy called Trauma-Focused Psychodynamic Psychotherapy (TFPP) for veterans with PTSD who haven't gotten better with standard treatments. About 75 veterans will be randomly assigned to either TFPP or their usual care. The goal is to see if TFPP c…

This study looks at which parts of therapy work best to help children aged 8-17 with post-traumatic stress disorder (PTSD) after a traumatic event. Researchers will compare different treatment components to a placebo to see what reduces symptoms most effectively. About 200 childr…

This study is testing whether a type of talk therapy called metacognitive therapy (MCT) can be delivered in a group setting for people with post-traumatic stress disorder (PTSD) in regular psychiatric care. The goal is to see if it is practical and acceptable to patients, and to …

This study tests whether a nasal spray containing insulin can reduce symptoms of post-traumatic stress disorder (PTSD). Researchers will enroll 20 adults with current PTSD to see if the treatment helps. The goal is to find a new way to ease PTSD symptoms.

This study tests a psycho-education program for 60 adults who have experienced sexual violence. The program teaches coping skills and understanding of trauma. Researchers will measure changes in quality of life, self-esteem, and mental well-being to see if the program helps.

This study is testing a digital therapeutic app called OTX-601 to see if it can reduce symptoms of post-traumatic stress disorder (PTSD) in adults. About 40 people with PTSD will use the app, and researchers will track changes in their symptoms over 27 weeks. The goal is to find …

This study tests whether a telehealth-based mental health program can help family members of ICU survivors cope with anxiety, depression, and PTSD. About 150 family members will use an online platform and have check-ins. The goal is to see if this approach is practical and helpfu…

This early-stage study tests whether psilocybin (the active ingredient in magic mushrooms) given in a group therapy setting is safe and helpful for people with PTSD. About 36 adults, including veterans, first responders, and survivors of sexual violence, will receive the treatmen…

This study tests whether adding augmented reality (AR) to standard exposure therapy helps U.S. military personnel with PTSD feel better faster. Forty veterans or active-duty members will be split into two groups: one gets AR-enhanced therapy, the other gets therapy alone. Researc…

This study is testing whether a low dose of clonidine, a drug usually used for high blood pressure, can help veterans with PTSD sleep better and feel less stressed. About 32 veterans will take the drug for 6 weeks while researchers track changes in sleep quality, PTSD symptoms, a…

This study looks at ways to help veterans with PTSD who are not getting better from their first treatment. It will test if switching to a different therapy or getting text message reminders to do homework between sessions improves symptoms. About 300 veterans will take part. The …

This study tests whether adding extra booster sessions and homework reminders to a short psychological program (PM+) can better reduce stress, anxiety, and trauma symptoms in refugees and asylum seekers. About 1,200 participants aged 16 and older from Swiss communities will take …

This study tests a new group program called BEAR for women who have experienced trauma and have current suicidal thoughts. The program combines psychological skills, education about trauma, and physical self-defense training. Researchers want to see if it's possible to run the pr…

This study is testing whether a specific type of acupuncture can help reduce symptoms of post-traumatic stress disorder (PTSD) in 75 active-duty military members and their families. Participants will receive acupuncture and be monitored using standard PTSD questionnaires and bloo…

This study tests whether a handheld device that gently stimulates the vagus nerve (gammaCore) can safely reduce PTSD symptoms. About 40 adults with PTSD will use the device at home daily for 12 weeks. Researchers will track symptom changes and side effects to see if this approach…

This study compares two types of talk therapy—exposure therapy and interpersonal therapy—for PTSD caused by military sexual trauma. About 208 survivors will receive one of the two treatments to see if they are equally effective at reducing PTSD symptoms. The goal is to offer more…

This study tests whether a group therapy called Cognitive Processing Therapy (CPT) can reduce PTSD symptoms and rule-breaking in incarcerated adults. About 900 participants from six prisons will join the 24-week program. The goal is to see if this community-used therapy works beh…

This study is testing whether a 12-week therapy program called ECCCLORE is practical and acceptable for people who have both post-traumatic stress disorder (PTSD) and addiction. The program combines skills for managing emotions, stress, and relationships. Researchers will enroll …

This study looks at whether art therapy can help active-duty military members and recent veterans who have posttraumatic stress symptoms. Participants will attend eight art therapy sessions and have two MRI scans to see how the therapy affects emotional expression and brain activ…

This study tests a 1-month online self-management program for people who recently received a shock from their implantable defibrillator (ICD). The program teaches heart rate self-monitoring and coping skills to reduce anxiety and prevent post-traumatic stress disorder (PTSD). 60 …

This study tests whether a single 25 mg dose of psilocybin, given with therapy, can safely reduce PTSD symptoms in 35 women who experienced sexual assault. Participants will be monitored for side effects and changes in their PTSD scores. The goal is to see if this approach is bot…

This study tests a non-trauma psychotherapy for military veterans and service members who have both PTSD and a mild or moderate traumatic brain injury (TBI). The treatment involves individual talk therapy sessions to help manage PTSD symptoms. The study will enroll 30 participant…

This study tests a mental health support program for 150 people who recently left the ICU. The program includes digital tools, coaching, and psychiatric help to reduce anxiety, depression, and PTSD symptoms. Participants are compared to those receiving usual care over six months.

This study tests a special version of cognitive behavioral therapy for insomnia (CBT-I) designed for women veterans who have both insomnia and PTSD. About 100 women will either get this therapy or a sleep education program. The goal is to see if improving sleep makes them more re…

This study tests whether a special brain training program, delivered either in-person or via telehealth, can improve attention and thinking skills in veterans with mild traumatic brain injury and PTSD. About 63 veterans will participate. The goal is to see if the remote option wo…

This early-stage study tests whether psilocybin from whole mushrooms is safe and may help ease PTSD symptoms. Up to 24 adults with long-term PTSD will take a single dose of dried mushrooms mixed into chocolate. Researchers will monitor side effects and measure how the drug moves …

This early-stage study at Yale tests whether a single 25mg dose of psilocybin is safe and tolerable for people whose daily life is affected by mood, anxiety, trauma, or addiction symptoms. Fifty participants will receive the drug and be followed for up to 6 weeks, with optional l…

This study tests a 12-16 week online program called Parenting STAIR for military-connected mothers who have experienced trauma and have young children ages 2-10. The program helps moms manage strong feelings from past stress and improve their parenting. Researchers will compare i…

This study compares group-based MDMA-assisted therapy to individual sessions for people diagnosed with PTSD after the events of October 7, 2023. Researchers want to see if group therapy is as safe and effective as individual therapy. 168 adults will receive MDMA along with talk t…

This study compares a new type of therapy that combines computer sessions with therapist support (blended CBT) to the current best treatment for PTSD. About 160 adults with PTSD will take part at clinics in Sweden. The goal is to see if the new approach works just as well at redu…

This study tests whether adding memory-support techniques to standard PTSD therapy helps people learn and remember key therapy content. About 100 adults with PTSD will receive either standard therapy or therapy with extra memory aids. The goal is to see if better memory of therap…

This study tests a therapy called Targeted Cognitive Training (TCT) for veterans with serious mental illnesses like schizophrenia, bipolar disorder, or PTSD. TCT uses brain exercises to improve how the brain processes information, with the goal of boosting thinking skills and dai…

This study tests whether exercise can improve how well people with PTSD learn to overcome fear. 200 adults with PTSD will do a fear-learning task and then either rest or exercise at different intensities. Researchers will measure fear responses and brain activity to see if exerci…

This study looks at whether a procedure called a bilateral cervical sympathetic block (BCSB) can help reduce symptoms of PTSD, anxiety, and traumatic brain injury in Special Operations Veterans. Some participants will receive the block alone, while others will also get structured…

This is a small pilot study to test a new virtual therapy program designed to treat PTSD and chronic pain at the same time. The program combines techniques from two established therapies over 12 online sessions. Researchers will check if the combined approach is practical and acc…

This study looks at how taking potato starch or cellulose (a fiber) affects the gut bacteria of 30 Veterans who have both cirrhosis (liver scarring) and PTSD. The goal is to see if these supplements can change the types and amounts of bacteria in the gut. This is not a treatment …

This study looks at whether using a short-acting paralytic drug (succinylcholine) instead of a longer-acting one (rocuronium) can prevent patients from being awake and aware while paralyzed on a breathing machine in the emergency room. About 3,090 adults on ventilators will take …

This study looks at how a type of talk therapy for PTSD changes brain activity related to feeling pleasure. Researchers will use brain scans to see if therapy helps the brain process rewards better. The goal is to understand why some people feel less joy after trauma and how ther…

This study looks at whether a computer-based working memory training program can help veterans with PTSD improve how they learn to stop being afraid. Researchers will use brain scans and behavioral tests to see if the training changes brain activity linked to fear extinction. The…

This study uses advanced PET/MRI scans to see how exercise affects brain activity and blood vessel inflammation in people with PTSD who also have or are at risk for heart disease. Researchers will measure heart rate, blood pressure, and inflammation in arteries and bone marrow. T…

This study looks at how exercise affects learning and memory in people with PTSD. One hundred adults who have PTSD from interpersonal violence will have MRI scans while recalling a traumatic memory, then do either moderate or light exercise. The next day, they repeat the MRI to s…

This study looks at whether taking estradiol (a form of estrogen) can help reduce the number of intrusive, unwanted memories after a traumatic event. Healthy female volunteers will watch a stressful film and then take either estradiol or a placebo. Researchers will track how many…

This study looks at whether a program called Coffee and Family Education and Support (CAFES2) helps refugee families from Arabic-speaking countries feel less depressed, anxious, or stressed. About 74 families in Chicago will take part. The program is led by trained peers and focu…

This study compares two different screening methods for PTSD in pregnant Black women to see which one better improves mental health, use of prenatal care, and birth outcomes. About 804 women in their first trimester who have experienced at least one traumatic event will take part…

This study tests a faster way to find and treat PTSD in primary care clinics on Chicago's South Side, where trauma is common. Researchers will track how many people get screened, diagnosed, and start treatment, and whether their symptoms improve. About 17,000 adults who have had …

This study looks at how living with congenital heart disease from birth may increase the risk of post-traumatic stress disorder (PTSD). Researchers will survey 1,000 adults and interview some to find out which experiences—like past surgeries or bullying—are linked to PTSD. They a…

This study aims to see if community-based mental health services can improve depression, anxiety, and PTSD. About 1,000 adults with mild to moderate psychological distress will receive these services and be tracked over time. The goal is to learn what works best to support mental…

This study observes 200 people already taking psychedelics in other trials to understand how these drugs change brain processing. Researchers use brain scans, computer tasks, and interviews to measure shifts in learning, perception, and electrical activity. The goal is to predict…

This study looks at how a non-invasive brain stimulation technique called TMS affects the brain's fear circuits. Researchers want to understand how to best use TMS to help people with PTSD strengthen their ability to unlearn fear. The study will involve 250 adults, including thos…

This study aims to understand the brain mechanisms behind fear and anxiety in people with anxiety disorders like PTSD and GAD. Researchers will measure brain activity, heart rate, and skin responses while participants view fear-provoking images or use virtual reality. The goal is…

This study looks at how trauma-focused therapy changes brain connections in teenagers with PTSD. Researchers will use brain scans before and after each phase of therapy to understand which parts of the brain are affected. The goal is to learn more about how therapy works, which c…