PTSD

This early-stage study is testing whether combining standard psychiatric medications (like antidepressants and anti-anxiety drugs) with individual cognitive behavioral therapy can improve symptoms and daily functioning in people with anxiety, depression, PTSD, OCD, bipolar disord…

This study looks at whether a therapy called RRFT, which treats substance use and PTSD together, works better than standard separate treatments for teens aged 13-18. About 212 teens with both conditions will be randomly assigned to RRFT or usual care, and tracked for a year. The …

This early study tests whether brexanolone, a drug already approved for postpartum depression, can safely reduce stress-induced alcohol use in 25 adults with both PTSD and alcohol use disorder. Participants receive a continuous 20-hour IV infusion under medical supervision. The m…

This study offers voluntary screening for newborns in North Carolina to detect a wide range of rare health conditions early. Using a small blood sample already collected at birth, the program tests for dozens of disorders, including spinal muscular atrophy, cystic fibrosis, and m…

This study tests whether a workshop led by fellow firefighters can help prevent PTSD, depression, anxiety, and alcohol problems in new firefighter recruits. About 480 trainees will take part in either an emotion regulation workshop or a standard education session during their aca…

This study compares a shorter therapy focused on guilt (TrIGR) to a standard PTSD therapy (CPT) in 160 U.S. Veterans. The goal is to see if TrIGR is no less effective at reducing PTSD, depression, and guilt symptoms. Participants are randomly assigned to one of the two treatments…

This study tests whether injecting a dextrose (sugar water) solution around nerves in the neck can reduce PTSD symptoms like anxiety and brain fog. Twenty-four adults who have tried at least two medications and two non-drug treatments for PTSD will receive either the injection or…

This study looks at whether having therapy sessions in the morning or afternoon changes how well prolonged exposure therapy works for PTSD. About 52 adults with PTSD will receive 10 weekly therapy sessions via telehealth, either early in the day or late afternoon. Researchers wil…

This study tests a brief stepped care program for adults hospitalized after a traumatic injury who show signs of PTSD. The program starts in the hospital and aims to reduce PTSD symptoms and the number of emergency room visits over time. About 424 participants are involved, and t…

This study tests a 12-session group therapy program (G-BCBT) for active duty military personnel who have recent suicidal thoughts or a recent suicide attempt. The therapy teaches emotion regulation, cognitive flexibility, and relapse prevention skills. Researchers will measure ch…

This study looks at whether oxytocin, a natural hormone, can boost the effects of a special talk therapy for veterans who have both alcohol use disorder and PTSD. About 175 veterans will get either oxytocin or a placebo along with therapy. The goal is to see if oxytocin helps the…

This study looks at whether a special type of massage therapy, designed to be sensitive to trauma and different cultures, can help refugees and asylum seekers who survived torture or war. About 50 people will either get their usual care plus this massage, or just usual care. The …

This study tests whether psilocybin, the active ingredient in magic mushrooms, can safely help veterans with PTSD. Fifteen veterans will receive two doses of psilocybin in a supervised therapy setting. Researchers will monitor side effects and measure changes in PTSD symptoms.

This study tests whether a gentle electrical stimulation on the skin can improve sleep in veterans with PTSD. The device, similar to a TENS unit, targets two different nerve locations to see which works better. Researchers will measure sleep quality using overnight sleep tests in…

This study tests a therapy called Deep Brain Reorienting (DBR) for people with PTSD. DBR helps patients focus on physical tension linked to traumatic memories. 234 adults will be randomly assigned to either DBR or a waitlist, and researchers will measure changes in PTSD symptoms.

This study compares a one-week virtual talk therapy (Cognitive Processing Therapy) to a five-day relaxation training for reducing PTSD symptoms. About 140 adults with PTSD will participate to see which approach works better and how. The goal is to find faster, more effective ways…

This study looks at whether having a psychiatric service dog makes prolonged exposure therapy work better for veterans with PTSD. About 216 veterans who already qualify for a service dog will be randomly assigned to get the dog right away or later. The goal is to see if the dog h…

This study tests a 15-session creative writing program called REWRITALIZE for people with serious mental illnesses like schizophrenia, bipolar disorder, or severe depression. About 300 adults will either join the writing groups plus their usual care, or stay on a waiting list wit…

This study tests whether a single dose of MDMA, given during a 10-day intensive exposure therapy program, can improve PTSD symptoms more than therapy alone. About 40 adults with PTSD will participate at Emory University. The goal is to see if MDMA helps patients engage better wit…

This study tests whether a short form of talk therapy, called brief prolonged exposure therapy, can help prevent post-traumatic stress disorder (PTSD) in people who have had a spinal cord injury. The therapy involves three one-hour sessions during inpatient rehabilitation. Resear…

This study aims to find better ways to ensure veterans with PTSD, depression, or alcohol/opioid problems receive proven treatments. Currently, only 3-28% of patients get these effective therapies. Researchers will compare a participatory business engineering method (Participatory…

This study was designed to test a holistic education program for stress management in people from colonized English-speaking countries. It aimed to help with conditions like stress, PTSD, anxiety, and fatigue using pastoral counseling and self-care activities. However, the study …

This study will use brain scans to see how cannabis affects inflammation and brain activity in up to 100 U.S. military veterans with PTSD and suicidal thoughts. Participants will take cannabis for 12 weeks and have PET and MRI scans before and after. The goal is to link brain cha…

This study uses virtual reality to understand how people learn fear and safety. Participants already have a brain implant (RNS device) for epilepsy. They wear a VR headset while researchers measure brain activity, heart rate, and sweat. The goal is to better understand anxiety an…