PTSD

This study looks at whether combining medication with one-on-one cognitive behavioral therapy helps people with mental health disorders like anxiety, depression, bipolar disorder, and schizophrenia. 107 adults aged 18-65 with an IQ of 80 or higher took part. The goal is to see if…

This study looks at whether a therapy called RRFT, which treats both substance use and PTSD together, works better than standard separate treatments for teens aged 13-18. About 212 teens with trauma history and both conditions will be randomly assigned to RRFT or usual care. Rese…

This study tests whether a workshop led by fellow firefighters can help prevent PTSD, depression, anxiety, and alcohol problems in new firefighter trainees. About 480 recruits will take part during their academy training. They will either receive the emotion-regulation workshop o…

This study looks at whether adding a special type of massage therapy to regular mental health care can help refugees and asylum seekers who survived torture or war. About 50 people will take part, with some getting massage plus standard care and others getting standard care alone…

This early study tests whether a drug called brexanolone is safe and feasible for people who have both PTSD and alcohol use disorder. The goal is to see if it can help reduce stress-related drinking. The study involves 25 adults aged 21 to 55.

This study looks at whether having a psychiatric service dog helps veterans with PTSD get more out of a standard therapy called prolonged exposure therapy. About 216 veterans who already qualify for a service dog will take part. The goal is to see if the dog-and-therapy combo red…

This study tests whether stimulating a nerve in the ear or neck can improve sleep in veterans with PTSD. About 87 veterans will try one of two stimulation locations to see which helps them fall and stay asleep better. The goal is to find a new, non-drug way to treat sleep problem…

This study tests a brief form of therapy called Brief Prolonged Exposure (Brief PE) to see if it can reduce posttraumatic stress in people who have had a spinal cord injury. About 200 adults in inpatient rehab will either get this therapy or standard care. The goal is to ease PTS…

This study tests a brief stepped care program for adults hospitalized after a traumatic injury who show signs of PTSD. The program starts in the hospital and adjusts based on each person's needs, aiming to reduce PTSD symptoms and the number of emergency room visits. About 424 pa…

This study tests whether a single dose of MDMA (the drug in ecstasy) can make a proven talk therapy for PTSD work better. 40 adults with PTSD will receive MDMA on the second day of a 10-day intensive therapy program. The goal is to see if this combination reduces PTSD symptoms mo…

This study tests a 12-session group therapy program designed to help active duty military personnel who are having suicidal thoughts or have recently attempted suicide. The therapy teaches coping skills and emotion regulation techniques to reduce suicide risk. Researchers will co…

This study tests a therapy called Deep Brain Reorienting (DBR) for people with post-traumatic stress disorder (PTSD). 234 adults will be randomly assigned to receive DBR or join a waitlist. The goal is to see if DBR reduces PTSD symptoms like distress and flashbacks.

This study looks at whether psilocybin (the active ingredient in magic mushrooms) combined with therapy can safely help veterans with PTSD. Fifteen veterans will receive the treatment and be monitored for side effects and changes in PTSD symptoms. The goal is to see if this appro…

This study looks at whether adding oxytocin (a natural hormone) to a special talk therapy helps veterans with both PTSD and alcohol use disorder. About 175 veterans will get either oxytocin or a placebo before therapy sessions. Researchers will track changes in drinking habits an…

This study tests a 15-session creative writing program called REWRITALIZE for people with serious mental illnesses like schizophrenia, bipolar disorder, or severe depression. The program is led by a professional author and a mental health worker, and focuses on writing, sharing, …

This study compares two virtual treatments for PTSD: a 1-week intensive Cognitive Processing Therapy (CPT) and a 5-day relaxation training. About 140 adults with PTSD will participate to see which approach better reduces symptoms and to understand how the treatments work. The goa…

This study looks at whether having therapy sessions in the morning or late afternoon changes how well people with PTSD overcome fear. About 52 adults will receive 10 sessions of prolonged exposure therapy via telemedicine. Researchers will measure changes in stress responses and …

This study looks at 65 veterans with PTSD who use cannabis heavily. Researchers want to see if reducing cannabis use improves their daily functioning, mental health, and quality of life. No treatment or drug is given—just careful tracking of habits and well-being over time.

This study aimed to see if holistic pastoral counseling could help people manage stress at work and in daily life. It was designed for unmarried Alaska Medicaid recipients aged 22 and older who had internet access and a Bible. However, the study was withdrawn before any participa…

This study looks at why many veterans with PTSD, depression, or alcohol/opioid problems don't get proven treatments. It tests a method called Participatory System Dynamics, where patients, doctors, and leaders work together to improve care. The goal is to see if this approach wor…

This study looks at how people learn fear by using virtual reality. Participants, who already have a brain device for epilepsy, will wear a VR headset and have their brain activity, heart rate, and sweating measured. The goal is to better understand anxiety and PTSD to improve fu…

This study looks at how different types of cannabis affect the brains of U.S. military veterans with PTSD. Up to 100 veterans will get brain scans before and after 12 weeks of using cannabis. The goal is to see changes in brain inflammation, communication, and activity linked to …