Magic mushroom therapy tested for veteran PTSD

NCT ID NCT05554094

Ongoing Symptom relief Sponsor: Ohio State University Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study tests whether psilocybin, the active ingredient in magic mushrooms, can safely help veterans with PTSD. Fifteen veterans will receive two doses of psilocybin in a supervised therapy setting. Researchers will monitor side effects and measure changes in PTSD symptoms.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: psilocybin
What this could lead to: If it works, this could point toward a new treatment option for PTSD in veterans, potentially easing symptoms like flashbacks and anxiety.
What could go wrong: This is a very small, early-stage trial with only 15 people and no placebo group. Results may not apply to all veterans, and psilocybin can cause temporary psychological distress.

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Conditions

The condition(s) this trial relates to.

acute stress disorder mental disorder post-traumatic stress disorder psychiatric disorder Stress Disorders, Traumatic

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MENTAL DISORDER PTSD STRESS DISORDERS, POST-TRAUMATIC STRESS DISORDERS, TRAUMATIC TRAUMA AND STRESSOR RELATED DISORDERS

Contacts and locations

Locations

Ohio State University Department of Psychiatry and Behavioral Health at the Davis Medical Research Center

Columbus, Ohio, 43210, United States

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