STRESS DISORDERS, POST-TRAUMATIC

This study tests a new approach to treat PTSD by weakening traumatic memories. Participants take propranolol (a blood pressure drug) before briefly recalling their trauma, sometimes in an unexpected way (like singing the story). The goal is to see if this 'mismatch' method reduce…

This study tests whether adding a brief writing task, called AWARE, to standard PTSD therapies (CPT or PE) helps patients and therapists communicate better. About 54 adults with PTSD will take part. The goal is to see if AWARE makes treatment more effective and satisfying.

This study tests whether adding a memory-enhancing technique to standard PTSD therapy helps older veterans learn and remember therapy content better. About 30 veterans over age 59 with PTSD will take part. The goal is to see if this approach is feasible and reduces PTSD symptoms.

This study tests a non-invasive technique called Energy Resonance by Skin Stimulation (ERCS) to see if it can lower stress in patients recovering in a post-ICU rehabilitation unit. 38 adults will receive two sessions a week apart. Researchers will measure stress levels before and…

This study tests whether extra support from a doula (a trained birth coach) can help mothers of premature babies in the NICU feel less stressed, depressed, or anxious. Twenty mothers will receive doula support and help coordinating care, both in the hospital and after going home.…

This study tests an online, self-guided therapy program for current or former public safety personnel (like police, firefighters, paramedics) who struggle with depression, anxiety, or PTSD. About 164 participants across Canada will try different versions of the program to see whi…

This study looks at whether two types of talk therapy can help people who feel dirty inside after a sexual assault, even though they are physically clean. The study will enroll 12 adults with PTSD and these feelings. They will receive either Cognitive Processing Therapy or a Self…

This study tests whether a nerve block injection in the neck, combined with a fast-paced behavioral therapy, can better reduce PTSD symptoms in military members and retirees. Half of the 140 participants will get the real injection, and half will get a sham (fake) one, alongside …

This study explores whether MDMA-assisted therapy can help new mothers who struggle with both post-traumatic stress disorder (PTSD) and opioid use disorder. Fifteen participants will receive the therapy 6 to 12 months after childbirth. The goal is to see if it is safe and helpful…

This study tests a 3-session program called Omnis Salutis for recent veterans with PTSD, depression, anxiety, or substance use. The program teaches veterans about whole health and how to communicate their needs to doctors and loved ones. Researchers want to see if it improves soc…

This study tests whether people can reduce the emotional pain of intrusive memories by themselves using alternating bilateral stimulation (like eye movements or tapping). 150 adults with PTSD or high stress will try this technique at home. The goal is to see if it makes upsetting…

This study tests whether a new EEG neurofeedback system, Prism, can reduce PTSD symptoms in 250 US military veterans and civilians. Participants will do 15 training sessions over 8 weeks, plus two booster sessions. Researchers will compare real Prism training to a sham version to…

This study tests whether adding a group-based stabilization and skill-training program to regular individual therapy helps people with long-lasting post-traumatic stress. About 160 adults receiving outpatient mental health care will take part. Half will get the combined treatment…

This study tests whether a small device that gently stimulates a nerve in the neck can reduce PTSD symptoms in veterans. Eighty veterans will use the device or a fake version at home twice daily for three months. Researchers will measure changes in brain activity, heart function,…

This study is testing a brief, 3-session therapy called MERA, designed to help Veterans with PTSD better manage their emotions. The goal is to reduce impulsive, aggressive behavior and potentially prepare them for longer PTSD treatments. Researchers will compare MERA to a standar…

This study looks at how to train therapists more effectively in a proven PTSD treatment called Cognitive Processing Therapy (CPT). The goal is to find which training methods help therapists stick to the treatment plan, so veterans get better results. About 240 VA therapists will …