STRESS DISORDERS, POST-TRAUMATIC

This small study is testing whether MDMA-assisted therapy can help new mothers who have both post-traumatic stress disorder (PTSD) and opioid use disorder. Fifteen participants will receive MDMA in a controlled setting along with therapy sessions. The goal is to see if this appro…

This study tests a simple talking therapy for heart surgery patients while they are still in the ICU. The therapy uses a visitor book with photos and family messages to help patients process stressful memories. Researchers hope this can prevent posttraumatic stress disorder (PTSD…

This study tests a short, 3-session program called MERA (Manage Emotions to Reduce Aggression) for veterans with PTSD who struggle with impulsive aggression. The program teaches skills to manage emotions better, with the goal of reducing aggressive outbursts and preparing veteran…

This study tests whether adding an unexpected element (like singing) during memory reactivation, combined with the drug propranolol, can reduce physical stress responses to traumatic memories in people with PTSD. Eighty adults with trauma history will be randomly assigned to stan…

This study tests whether adding a group-based stabilization and skill-training program to regular individual therapy helps people with long-lasting post-traumatic stress recover better. About 160 adults receiving outpatient mental health care will take part. Half will get the com…

This study tests an internet-delivered cognitive behaviour therapy (ICBT) course designed specifically for public safety personnel (like police, firefighters, paramedics) who experience anxiety, depression, or PTSD. The 164 participants will be randomly assigned to different ways…

This study is testing whether adding a brief writing exercise (AWARE) to standard PTSD therapies like cognitive processing therapy (CPT) or prolonged exposure (PE) can improve patient-therapist communication and treatment outcomes. Researchers will enroll 54 adults with PTSD, fir…

This study tests a new EEG neurofeedback system called Prism for treating PTSD in 250 US veterans and civilians. Participants do 15 sessions of Prism training over 8 weeks, plus two booster sessions. The goal is to see if Prism reduces PTSD symptoms more than a sham (fake) traini…

This study tests whether a small device that gently stimulates a nerve in the neck can reduce PTSD symptoms in veterans. 80 veterans will use the device at home twice a day for three months. Researchers will measure changes in brain activity, heart function, and PTSD symptoms com…

This study tests a noninvasive technique called Energy Resonance by Skin Stimulation (ERCS) to reduce stress in patients recovering after an ICU stay. 38 adults in a post-ICU rehabilitation unit will receive two ERCS sessions a week apart. Researchers will measure stress levels b…

This study looks at whether a self-administered technique called alternating bilateral stimulation (like moving your eyes side to side or tapping your shoulders) can make intrusive, distressing memories feel less intense and less vivid. Researchers will enroll 150 adults with sym…

This study looks at whether two types of talk therapy can help people who feel dirty or contaminated inside after a sexual assault. 12 adults with PTSD will try Cognitive Processing Therapy and a self-compassion program. The goal is to reduce PTSD symptoms and the troubling feeli…

This study tests whether adding memory-support strategies to standard cognitive processing therapy (CPT) helps older veterans with PTSD learn and remember therapy content better. Thirty veterans over age 59 will receive either standard CPT or CPT with extra memory aids. The goal …

This study tests whether providing doula support and care coordination to parents of preterm babies in the NICU can reduce stress, depression, and anxiety. Twenty English-speaking mothers of babies born before 34 weeks are being recruited. The doula helps connect families to ment…

This study tests whether a one-time injection of a local anesthetic into a nerve bundle in the neck (stellate ganglion block) can improve the effects of a type of talk therapy called prolonged exposure for PTSD. The trial involves 140 current or retired military members with PTSD…

This study investigates whether a clinical test using lorazepam (Ativan) and brain imaging can identify veterans with PTSD who might benefit from medications that boost GABA signaling. Researchers aim to validate a computational method to distinguish subgroups of PTSD patients ba…

This study aims to understand why people with post-traumatic stress disorder (PTSD) have a higher risk of heart disease and high blood pressure. Researchers will measure nerve activity and test whether the drug losartan can lower high adrenaline levels during stress. The study in…

This study compares different training methods for therapists who treat PTSD. It aims to find the most effective way to train therapists so they stick to the proven treatment plan. 240 therapists will be assigned to various training components, like online courses or feedback ses…