Could a common blood pressure drug protect PTSD Patients' hearts?

NCT ID NCT02560805

Recruiting now Knowledge-focused Sponsor: Emory University Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study aims to understand why people with post-traumatic stress disorder (PTSD) have a higher risk of heart disease and high blood pressure. Researchers will measure nerve activity and test whether the drug losartan can lower high adrenaline levels during stress. The study includes 134 veterans aged 18-65 with and without PTSD.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: losartan
What this could lead to: If successful, this study could point toward a way to lower heart disease risk in people with PTSD by targeting nerve activity.
What could go wrong: This is an early-phase study with only 134 participants, so results may not apply to everyone. The main goal is to understand mechanisms, not to prove a treatment works.

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Conditions

The condition(s) this trial relates to.

post-traumatic stress disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

STRESS DISORDERS, POST-TRAUMATIC

Contacts and locations

Locations

Atlanta VA Medical Center
RECRUITING

Decatur, Georgia, 30033, United States

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Other studies related to the condition(s) this trial covers.