Could a blood pressure drug help treat PTSD and alcohol addiction together?
NCT ID NCT05692271
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether adding the blood pressure medication propranolol to cognitive processing therapy (a type of talk therapy) helps people with both post-traumatic stress disorder (PTSD) and alcohol use disorder. About 48 adults aged 18 to 70 with both conditions will receive either propranolol or a placebo twice daily for 12 weeks, along with weekly therapy sessions. The goal is to see if the combination is well-tolerated and reduces PTSD symptoms and heavy drinking.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Propranolol
What this could lead to
If it works, this could point toward a new treatment option for people struggling with both PTSD and alcohol use disorder.
What could go wrong
This is a small, early-phase proof-of-concept trial, so results may not apply broadly. Propranolol can cause side effects like low blood pressure and fatigue.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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CAMH
Toronto, Ontario, Canada