Brain test could match PTSD veterans to the right medication
NCT ID NCT06852469
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study investigates whether a clinical test using lorazepam (Ativan) and brain imaging can identify veterans with PTSD who might benefit from medications that boost GABA signaling. Researchers aim to validate a computational method to distinguish subgroups of PTSD patients based on anxious arousal. The study involves 150 veterans, some with PTSD and some without, who will take either lorazepam or a placebo and perform motor tasks while their brain activity is measured.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Lorazepam (Ativan)
What this could lead to
If successful, this could lead to a simple test that helps doctors match the right PTSD medication to each veteran, improving treatment outcomes.
What could go wrong
This is a small, early-phase study focused on validating a test, not on treatment itself. The test may not prove reliable, and results may not apply to all PTSD patients.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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VA San Diego Healthcare System, San Diego, CA
RECRUITINGSan Diego, California, 92161-0002, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••