PTSD

This study tests whether a 5-day accelerated form of transcranial magnetic stimulation (TMS) can reduce PTSD symptoms in veterans. About 90 veterans with chronic PTSD who still have symptoms despite current treatments will receive either real or sham TMS. The goal is to see if th…

This study tests whether a lab-made psilocybin drug called COMP360 can reduce symptoms of post-traumatic stress disorder (PTSD). About 300 adults with PTSD will receive either a high or low dose of COMP360 along with support from a trained team. The main goal is to see if symptom…

This study tests whether a single dose of psilocybin (the active ingredient in magic mushrooms) combined with intensive therapy can help people with chronic PTSD. Fifteen adults with moderate to severe symptoms will participate, and they must stop other psychiatric medications du…

This study tests whether virtual reality (VR) can help people who feel traumatized after COVID-19. About 100 healthcare workers and COVID-19 survivors will use VR to safely face and process their stressful memories. The goal is to reduce PTSD, anxiety, and depression over 5 weeks…

This study looks at whether adding cannabis to standard therapy can help veterans with PTSD feel less anxious, depressed, or suicidal. Researchers will give cannabis to 280 veterans who rarely use it now and track their symptoms using interviews and brain scans. The goal is to se…

This study tests whether HB-1 can safely reduce PTSD symptoms compared to a placebo. It involves 200 adults aged 18 to 65 with PTSD. Participants take HB-1 or placebo for 12 weeks, and doctors measure symptom changes using a standard PTSD scale.

This study tests whether psilocybin, the active ingredient in magic mushrooms, combined with talk therapy can safely reduce PTSD symptoms in veterans. About 150 Georgia veterans will receive either psilocybin with supportive therapy or psilocybin with prolonged exposure therapy. …

This study tests if a simple injection of dextrose (sugar water) into the neck can reduce anxiety, brain fog, and depression in people with PTSD who haven't improved with standard treatments. Fifty adults who have tried at least two medications and two non-drug therapies will rec…

This study tests whether a self-guided mobile app for cognitive behavioral therapy for insomnia (CBTI) can improve sleep in 144 active-duty service members. Participants use the app for five weeks, and researchers measure changes in insomnia severity, depression, PTSD symptoms, a…

This study tests whether adding a nerve block injection (SGB) to standard talk therapy (CPT) can better reduce PTSD symptoms. 270 adults with PTSD will receive either both treatments, CPT plus a placebo injection, or SGB alone. The goal is to see if the combination leads to great…

This study looks at whether a special smartwatch can help warfighters who have trouble sleeping due to PTSD, traumatic brain injury, or chronic stress. The watch detects signs of a stressed nervous system during sleep and gives gentle vibrations to calm it. Researchers will track…

This study tests whether suvorexant, a medication already used for insomnia, can help Veterans with PTSD and sleep problems better process and reduce fear responses. About 40 Veterans will take the drug for 7 nights and undergo fear conditioning and extinction tests. The goal is …

This study aims to find out which factors—like how flexible your thinking is, how much support you have, and your body's stress response—can predict if someone will develop PTSD after a major injury. Researchers will follow 250 adults treated in the emergency department for 6 mon…

This study reviews data from 80 veterans and first responders who completed a 12-week wellness program that included therapy, physical training, and nutrition advice. Researchers will analyze sleep, activity, heart health, and mental health surveys to see how the program helped. …

This study looks at stress and PTSD in Black teenage girls (ages 14-18) who have been involved with the justice system, along with their parents or caregivers. Researchers will test a mindfulness-based program to see if it helps reduce symptoms and understand what makes it easier…

This study works with 40 veterans who have PTSD to understand why many don't start proven treatments like cognitive processing therapy (CPT) or prolonged exposure therapy (PE). Researchers will look at the different treatments veterans try first and how that affects their path to…

This study follows 300 Ukrainian veterans with combat-related amputations to see if longer evacuation times and tourniquet use increase the risk of PTSD. Participants will be tracked for 18 months using PTSD symptom questionnaires. The goal is to identify key risk factors to impr…

This study is testing a new, non-invasive brain stimulation method called temporal interference (TI) to see how it affects the brain and behavior. Researchers will study healthy people and those with anxiety or PTSD to understand TI's effects. The goal is to learn more about how …