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Could MDMA help heal PTSD in soldiers? new trial investigates

NCT ID NCT07704762

Not yet recruiting Disease control Sponsor: U.S. Army Medical Research and Development Command Source: ClinicalTrials.gov ↗

First seen Jul 15, 2026 · Last updated Jul 16, 2026 · Updated 1 time

Summary

This study tests whether MDMA, combined with a type of talk therapy called Acceptance and Commitment Therapy (ACT), can help treat post-traumatic stress disorder (PTSD) in military service members. Participants receive either a full or low dose of MDMA during therapy sessions. The goal is to see if this approach reduces PTSD symptoms and if the effects last over time.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
MDMA (3,4-Methylenedioxymethamphetamine) combined with Acceptance and Commitment Therapy
What this could lead to
If successful, this could provide a new, effective treatment option for PTSD in military service members, potentially reducing severe symptoms and improving quality of life.
What could go wrong
This is an early Phase 2 trial with only 86 participants, so results may not apply broadly. MDMA can cause side effects like increased heart rate and anxiety, and the therapy requires careful supervision.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

combat disorder injury post-traumatic stress disorder psychiatric disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

POST-TRAUMATIC STRESS DISORDER POST-TRAUMATIC STRESS DISORDER (PTSD) PTSD

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

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