POST-TRAUMATIC STRESS DISORDER

This study compares two sedative drugs—dexmedetomidine and midazolam—in children aged up to 11 years who are on breathing machines in the ICU. The goal is to see which drug better reduces delirium (sudden confusion) and improves recovery. About 372 children will take part, and re…

This study tests whether an online, therapist-guided program called CIPE can prevent post-traumatic stress disorder (PTSD) in people who recently experienced a trauma. About 360 adults receiving support from crisis teams in Norway will either get the online program plus usual car…

This study tests whether a breathing exercise called cardiac coherence can help prevent chronic post-traumatic stress disorder (PTSD) in people who recently experienced a traumatic event. Researchers will enroll 44 adults with acute stress disorder and teach them the breathing te…

This study tests a new drug called TSND-201 to see if it can safely reduce PTSD symptoms. About 300 adults with PTSD will receive either one of two doses of TSND-201 or a placebo once a week for 4 weeks, then be followed for 8 more weeks. The goal is to measure changes in PTSD sy…

This study tests a personalized, noninvasive brain stimulation treatment (TMS) for people aged 18-65 with persistent symptoms after a mild concussion or brain injury, such as headache, dizziness, brain fog, or anxiety. Participants will receive either active or sham TMS over 10 s…

This study tests a stepped approach to help people with PTSD get effective treatment. Participants start with a digital program and may move to brief therapy if needed. The goal is to improve access, engagement, and symptom relief for 428 adults at Boston Medical Center.

This study tests whether a single dose of MDMA (the drug in ecstasy) can make a two-week intensive exposure therapy more effective for adults with PTSD. About 200 participants will receive either MDMA or a placebo during therapy, and their PTSD symptoms will be measured one month…

This study looks at whether treating sleep apnea early can improve long-term outcomes for veterans with both PTSD and substance use disorder. About 194 veterans in a residential treatment program will either receive sleep apnea treatment right away or be placed on a waitlist. The…

This study tests a technique called heart rate variability biofeedback, which uses breathing exercises to help people with long-lasting symptoms after a mild concussion. The goal is to reduce issues like headaches, dizziness, memory problems, and mood changes. The trial includes …

This study tests a digital program designed to help immigrant women who have faced violence and struggle with PTSD or depression. The program provides tools to reduce stress, improve safety, and build self-care habits. Researchers will enroll 676 women to see if the app-based app…

This study is testing whether the antidepressant fluoxetine can help reduce PTSD symptoms in 200 active-duty service members and veterans. Participants will receive either the drug or a placebo, and researchers will track changes in symptom severity and safety over 12 weeks. The …

This study compares two programs designed to help female Veterans who have experienced military sexual trauma or intimate partner violence and also have a brain injury. The goal is to see which program better improves emotion regulation and reduces PTSD symptoms. About 136 women …

This study tests a treatment called SMART, which uses movement and body awareness to help adults with PTSD. 80 participants will attend 8 sessions and complete assessments before, after, and 3 months later. The goal is to see if this approach reduces PTSD symptoms and improves bo…

This study tests a new fast-dissolving film (BXCL501) to see if it can reduce severe stress and prevent PTSD in people who have just been in a car accident. About 100 adults will receive the film or a placebo in the emergency room and take it at home for two weeks. Researchers wi…

This study tests whether involving a romantic partner in PTSD therapy helps veterans function better in daily life compared to standard therapy alone. About 420 post-9/11 veterans in committed relationships will receive either partner-assisted or individual therapy. The goal is t…

This study tests a new training program for veterans who have both mild traumatic brain injury (mTBI) and PTSD. The program combines emotion recognition exercises with attention training to help them better understand facial expressions and tone of voice. Researchers hope this wi…

This study tests whether sitting in bright light for 60 minutes each morning can improve sleep quality in veterans who have had a traumatic brain injury (TBI) and may also have PTSD. Researchers will track sleep with a wrist monitor and questionnaires before, during, and after 4 …

This study is testing a digital therapeutic app called OTX-601 to see if it can reduce symptoms of post-traumatic stress disorder (PTSD) in adults. About 40 people with PTSD will use the app, and researchers will track changes in their symptoms over 27 weeks. The goal is to find …

This study tests several potential medications for PTSD in 800 active-duty service members and veterans. Participants are randomly assigned to receive either a study drug or a placebo (a pill with no active medicine). The goal is to see if these drugs can reduce PTSD symptoms, li…

This study tests whether a lavender oil capsule called Silexan can reduce PTSD symptoms in adults. About 278 people with PTSD will take either Silexan or a placebo daily for 12 weeks, alongside their usual care. Researchers will measure symptom changes using a standard PTSD scale…

This study tests whether a 5-day intensive therapy for PTSD works as well as the usual 15-week program. About 140 adults with PTSD will be randomly assigned to either the fast or standard treatment. Researchers will measure symptom changes, costs, and therapist experiences to see…

This study tests whether a telehealth behavioral therapy can reduce PTSD and depression symptoms in adults who recently experienced a motor vehicle collision. Twenty high-risk participants will receive either the therapy or a control session. The goal is to see if this approach i…

This study tests whether adding augmented reality (AR) to standard exposure therapy helps U.S. military personnel with PTSD feel better faster. Forty veterans or active-duty members will be split into two groups: one gets AR-enhanced therapy, the other gets therapy alone. Researc…

This study tests whether a sleep medication called daridorexant can help reduce PTSD symptoms in 200 active-duty service members and veterans. Participants will receive either the drug or a placebo, and researchers will track changes in PTSD severity and safety over 12 weeks. The…

This study tests whether adding a non-invasive brain stimulation technique called rTMS to a brief writing therapy (WET) can better reduce PTSD symptoms in veterans. About 98 veterans with PTSD will receive either real or fake rTMS before their therapy sessions. The goal is to see…

This study is testing whether a specific type of acupuncture can help reduce symptoms of post-traumatic stress disorder (PTSD) in 75 active-duty military members and their families. Participants will receive acupuncture and be monitored using standard PTSD questionnaires and bloo…

This study tests whether a single IV dose of allopregnanolone (a natural brain chemical) can help people with chronic PTSD get more out of therapy. The drug may help the brain better process traumatic memories by either strengthening new learning or weakening old fear responses. …

This study tests a mobile app called Blueprint that teaches coping skills to people who survived a serious illness in the ICU. Many survivors struggle with anxiety, depression, and PTSD, but few have access to mental health care. The app aims to help them manage these symptoms on…

This study is testing whether a type of talk therapy for trauma, called trauma-focused cognitive behavioral therapy, can be done effectively over video calls for adults with PTSD or complex PTSD. Researchers will enroll 13 people from community mental health services and hospital…

This study tests whether having a dream while under anesthesia can reduce PTSD symptoms. 42 adults with PTSD will be randomly assigned to either deep sedation (to trigger dreams) or light sedation (without dreams). Researchers will compare changes in PTSD severity before and afte…

This study tests whether cannabidiol (CBD) can reduce PTSD symptoms and improve thinking problems. It includes 120 adults with PTSD, half of whom also have a mild traumatic brain injury. Participants take either a daily CBD capsule (400 mg or 800 mg) or a placebo for 8 weeks. The…

This study tests whether a single 25 mg dose of psilocybin, given with therapy, can safely reduce PTSD symptoms in 35 women who experienced sexual assault. Participants will be monitored for side effects and changes in their PTSD scores. The goal is to see if this approach is bot…

This study tests a non-trauma psychotherapy for military veterans and service members who have both PTSD and a mild or moderate traumatic brain injury (TBI). The treatment involves individual talk therapy sessions to help manage PTSD symptoms. The study will enroll 30 participant…

This study looks at ways to help veterans with PTSD stay in therapy and get better results. Researchers will compare two approaches: sticking with Cognitive Processing Therapy (CPT) or switching to Present Centered Therapy (PCT) when challenges arise. The goal is to find the best…

This study tests a new therapy called RTM (Reconsolidation of Traumatic Memories) to help people in Ukraine with PTSD. Unlike traditional talk therapy, RTM uses guided imagery to reduce distress from traumatic memories in just a few sessions, without needing to relive the trauma.…

This study tests whether an 8-week virtual reality adventure exergaming program can improve physical activity, mood, and thinking in women veterans aged 18-45. Participants will play VR games that involve movement, and researchers will measure changes in depression, anxiety, PTSD…

This study tests whether a computer-based cognitive training program can improve thinking skills like memory and attention in people with anxiety, depression, or PTSD. 128 adults aged 21-55 will be randomly assigned to either the active training or a sham version. The goal is to …

This study is testing whether a carbon dioxide (CO2) breathing challenge can help predict which people with anxiety, OCD, PTSD, or panic disorder will not respond to exposure-based therapy. Researchers will enroll 600 adults aged 18 to 70. The goal is to see if this easy test can…

This study looks at how prolonged exposure therapy helps people with PTSD. Researchers will measure brain activity, stress responses, and symptoms before, during, and after 10 therapy sessions. The goal is to understand why the therapy works and who benefits most. 50 adults with …

This study aims to understand how teenagers with post-traumatic stress disorder (PTSD) experience their psychotherapy. By interviewing 65 teens, their parents, and therapists, researchers hope to learn what helps them heal. The goal is to improve therapy for young people by focus…

This study looks at why young women with PTSD may have higher heart disease risk later in life. Researchers will give beetroot juice to 30 premenopausal women with trauma exposure to see if it improves blood vessel function. The goal is to understand how PTSD affects the body, no…

This study tests a new, non-invasive way to weaken fear memories shortly after a traumatic event. Researchers will use brain imaging and mild stimulation to see if they can disrupt how the brain stores scary memories. The goal is to lower the risk of developing PTSD. The study in…

This study looks at whether a computer-based working memory training program can help veterans with PTSD improve how they learn to stop being afraid. Researchers will use brain scans and behavioral tests to see if the training changes brain activity linked to fear extinction. The…

This study looks at how having PTSD might change the way people make decisions after drinking alcohol. Researchers want to understand why some people with PTSD develop alcohol problems. They will give 200 adults either alcohol or a placebo and use brain scans to see how their bra…

This study looks at why people with PTSD often have higher risk for heart problems, focusing on an overactive 'fight-or-flight' nervous system. Researchers will test two daily therapies—a breathing technique (DGB) and a mild nerve stimulation device (tVNS)—over 8 weeks in 120 vet…

This study aims to understand how very brief exposure to combat-related images affects brain activity and fear in U.S. combat veterans with PTSD. Participants will view both very brief and visible combat images during an fMRI scan and rate their fear, awareness, and tolerance. Th…

This study tests a new method to personalize TMS (a brain stimulation therapy) for people with PTSD, with or without mild traumatic brain injury. Researchers will use a brain imaging technique called fNIRS to directly measure brain activity and adjust the TMS dose for each person…

This study looks at how a stay in the intensive care unit (ICU) affects a person's quality of life and risk of post-traumatic stress disorder (PTSD). Researchers will ask 40 adults who spent more than 48 hours in the ICU to fill out questionnaires about their experience and well-…

This study looks at how sleep and emotions are linked in teenagers with post-traumatic stress disorder (PTSD). Researchers will test if improving sleep quality can help teens feel better the next day. About 180 teens aged 15-18 will take part in sleep studies, surveys, and brain …

This study is looking at whether simple, non-invasive eye scans can help detect and track brain diseases like Alzheimer's, Parkinson's, and multiple sclerosis. Researchers will use special cameras to take detailed pictures of the retina in 2,000 adults—both those with and without…