MDMA therapy trial targets PTSD and alcoholism in veterans

NCT ID NCT07118839

Recruiting now Disease control Sponsor: VA Office of Research and Development Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether MDMA-assisted therapy can help veterans with both PTSD and alcohol use disorder. Eighty veterans will receive either a full dose of MDMA or a low-dose placebo during three therapy sessions. Researchers will measure changes in PTSD symptoms and drinking habits over about 16 weeks.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: MDMA (midomafetamine hydrochloride)
What this could lead to: If successful, this could provide a new treatment option for veterans struggling with both PTSD and alcohol use disorder, potentially reducing symptoms and drinking.
What could go wrong: This is an early-phase trial with only 80 participants. The active placebo design may limit clear results, and MDMA has known risks like increased heart rate and psychological distress.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

alcohol abuse post-traumatic stress disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALCOHOL USE DISORDER POST-TRAUMATIC STRESS DISORDER

Contacts and locations

Locations

Providence VA Medical Center, Providence, RI
RECRUITING

Providence, Rhode Island, 02908-4734, United States
VA Connecticut Healthcare System West Haven Campus, West Haven, CT
RECRUITING

West Haven, Connecticut, 06516-2770, United States

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