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Can a single IV dose rewire PTSD memories? new trial investigates.

NCT ID NCT07079761

Recruiting now Symptom relief Sponsor: Massachusetts General Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a single intravenous dose of allopregnanolone, compared to a placebo, can help people with PTSD better process and reduce the power of traumatic memories. The trial involves 96 adults with chronic PTSD and uses skin conductance and startle responses to measure changes in fear reactions. The goal is to see if the drug can improve how the brain 'unlearns' fear or blocks the re-storage of traumatic memories.

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Conditions

The condition(s) this trial relates to.

injury post-traumatic stress disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

POST-TRAUMATIC STRESS DISORDER

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Massachusetts General Hospital

    RECRUITING

    Boston, Massachusetts, 02114, United States

    Contact

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact Phone: •••-•••-•••• Email: •••••@•••••

More trials for these conditions

Other studies related to the condition(s) this trial covers.