Brain scans and heart rate may reveal why PTSD therapy works
NCT ID NCT05788302
First seen Nov 15, 2025 · Last updated Jun 23, 2026 · Updated 29 times
Summary
This study looks at how prolonged exposure therapy helps people with PTSD. Researchers will track 50 adults over 17 weeks, using brain scans, heart rate, and questionnaires before, during, and after treatment. The goal is to understand the mechanisms behind the therapy, not to test if it works.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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MGH
RECRUITINGBoston, Massachusetts, 02114, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
prolonged exposure therapy
What this could lead to
If successful, this study could reveal how and why prolonged exposure therapy works for PTSD, helping to improve and personalize treatment.
What could go wrong
This is a small pilot study (50 people) focused on understanding mechanisms, not proving effectiveness. Results may not apply to everyone with PTSD.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.