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Can a therapy that tackles both PTSD and everyday stress help those most at risk?

NCT ID NCT07714083

Symptom relief Sponsor: Boston University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 20, 2026 · Last updated Jul 21, 2026 · Updated 1 time

Summary

This pilot study tests a version of cognitive processing therapy (CPT) that has been adapted to also address stress from lived experiences, such as discrimination or identity-related challenges. The trial enrolls sexual and gender minority adults with PTSD who report distress from these experiences. Participants receive either standard CPT or the adapted version (CPT-LEAP) to see if the new approach better reduces PTSD symptoms.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
a modified form of cognitive processing therapy called CPT-LEAP that addresses both PTSD and stress from lived experiences
What this could lead to
If successful, this could point toward a more effective PTSD treatment tailored for sexual and gender minorities, potentially reducing health disparities.
What could go wrong
This is a small pilot study with only 52 participants, so results may not apply broadly. The modified therapy may not prove more effective than standard CPT.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 52 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Oct 2026

An estimate. Start dates often move.

Expected to finish

Jul 2030

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Current diagnosis of PTSD * Self-identification as a sexual or gender minority (SGM) individual * Endorsement of SGM stress experiences with moderate distress * For patients who take psychiatric medication, stable dose one month prior to enrollment * Reside in Massachusetts. Exclusion Criteria: * Current active suicidal or homicidal ideation with intent or plan * Unstable bipolar disorder/current mania * Unstable psychotic disorder/current psychosis * Current severe substance use that warrants immediate medical attention * Cognitive impairment or organic disorder (e.g., advanced dementia, severe traumatic brain injury) that impairs ability to complete CPT procedures * Past completion of CPT or current trauma-focused treatment * Unwillingness to consent to audio or video recording of assessment and treatment sessions

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Conditions

The condition(s) this trial relates to.

post-traumatic stress disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Post-traumatic stress disorder

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • VA Boston Healthcare System

    Jamaica Plain, Massachusetts, 02130, United States

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