Boston University

This study compares a group program called Strength at Home (SAH) to standard court-mandated interventions for men who have used intimate partner violence (IPV) in Washington State. About 800 men will be randomly assigned to either SAH or treatment as usual, and researchers will …

This study tests a 5-session virtual program called MATTER for 256 people living with HIV and substance use disorders in Boston and Miami. The program uses text messages and coaching to help people manage shame and stigma, set health goals, and stay connected to HIV care. The goa…

This study aims to help people with HIV stay in care, especially during the first six months of treatment when the risk of dropping out is highest. Researchers will create and test a toolkit that includes risk assessments, a treatment roadmap, and a WhatsApp support coach. The st…

This study tests whether a combination cream (5-fluorouracil plus calcipotriene) applied for just 7 to 14 days can clear two types of low-risk skin cancer: superficial basal cell carcinoma and squamous cell carcinoma in situ. About 200 adults will receive either the combination c…

This study tests whether text messages about HIV prevention, sent to dental patients at community health centers, can increase HIV testing and use of preventive medications like PrEP. About 266 HIV-negative adults with at least one HIV risk factor will receive either HIV-focused …

This study tests a new therapy called Written Exposure Therapy for Suicide Prevention (WET-SP) in 160 active duty military members hospitalized for suicidal thoughts or attempts. Participants either receive the therapy plus standard care, or standard care alone. The therapy invol…

This study tests whether a short, evidence-based therapy for PTSD (Written Exposure Therapy) can be effectively delivered by community health workers to pregnant women. The goal is to make treatment more accessible and reduce PTSD symptoms during pregnancy and after childbirth. A…

This study tests whether a short telehealth interview 3-7 days before a dental checkup helps patients with intellectual or developmental disabilities (IDD) have a smoother visit. About 50 youth with IDD and their caregivers will be randomly assigned to receive the telehealth call…

This study tests a telehealth program called MCBMAP that combines counseling and skills training to help people with HIV reduce chronic pain and unhealthy drinking. The program is delivered entirely through video calls and online materials, making it easier for participants to jo…

This study looks at whether adding a peer support program (WoVeN) to a self-help version of Cognitive Processing Therapy (CPT) helps women veterans with PTSD feel better and improve their mental well-being. About 100 women who have served in the U.S. military and have PTSD sympto…

This study tests whether wearing virtual reality (VR) glasses during oral surgery can lower anxiety and reduce the amount of sedation medicine needed. About 80 adults will be randomly assigned to either watch a relaxing VR video or wear plain protective glasses. The goal is to se…

This study looks at the best way to manage pain in young children after dental surgery done under general anesthesia. It compares giving ibuprofen alone, alternating ibuprofen and acetaminophen, or giving both together. About 75 children will take part, and their pain will be mea…

This study is testing whether adding a brief writing exercise (AWARE) to standard PTSD therapies like cognitive processing therapy (CPT) or prolonged exposure (PE) can improve patient-therapist communication and treatment outcomes. Researchers will enroll 54 adults with PTSD, fir…

This study tests whether adding special memory-support techniques to a standard PTSD therapy (Cognitive Processing Therapy) helps veterans learn and remember the therapy content better. About 100 adults with PTSD will take part. The goal is to see if better memory of therapy lead…

This study tests a new 3D-printed device that helps dentists give numbing injections more accurately for procedures on lower teeth. Traditional numbing methods fail up to 45% of the time, causing discomfort. The device uses a 3D scan to guide the needle to the right spot, aiming …

This study tests different types and doses of vitamin K in 55 adults aged 60 and older with knee osteoarthritis. Researchers want to see if vitamin K can improve knee health by measuring changes in blood markers. The goal is to find the best form and dose for future larger studie…

This study tests a stress management program called Self-Help Plus for women with breast or gynecologic cancer in Vietnam. The goal is to see if it helps reduce anxiety and depression and improves quality of life. About 285 women will take part, with half receiving the program an…

This study looks at two short counseling programs for veterans who have experienced intimate partner violence in the past year. One program offers up to 8 sessions covering topics like social support and health effects, while the other is a single session focused on safety and re…

This study in Malawi aims to understand why COVID-19 was much less severe there than in Europe and the Americas. Researchers will follow 1500 people, including those infected and their household contacts, to see how factors like prior infections, nutrition, and immune responses a…

This study looks at whether federal policy changes made during the COVID-19 pandemic helped more veterans get and stay on medication for opioid or alcohol use disorder. Researchers will compare treatment use, retention, and outcomes before and after the policy changes using data …

This study in Zambia will follow about 11,800 people with advanced HIV who are starting or restarting antiretroviral therapy (ART). Researchers want to learn who these patients are, what challenges they face, and how well they do in the first six months of treatment. The goal is …

This study follows 150 adults with advanced HIV who are hospitalized in South Africa. Researchers will interview them and review medical records to see if they successfully continue HIV care after leaving the hospital. The goal is to identify where the system fails and find ways …

This study is testing a new, non-invasive imaging technique called spatial frequency domain imaging (SFDI) to measure skin thickness in people with scleroderma. Currently, doctors use a subjective pinch test, but SFDI uses light scattering to measure collagen in the skin more acc…

This study from Boston University is checking how accurately wrist-worn devices like smartwatches measure exercise intensity. Fifty-four healthy adults will wear the devices while doing structured and everyday activities. Their movement data will be compared to a gold-standard br…

This study from Boston University is looking at how changes in the mouth, like wearing dental splints or dentures, can affect a person's balance and walking. Researchers will test 40 healthy adults, some with natural teeth and some with full dentures, using motion cameras and mus…

This study follows 10,000 pregnant women in Nagpur, India, from early pregnancy through 42 days after birth. Researchers want to learn if catching flu or COVID-19 raises the risk of problems like preterm labor or severe pre-eclampsia. The goal is to provide clear evidence to help…

This study will analyze medical records from up to 1 million people in Malawi to understand how different models of HIV treatment delivery are working. The goal is to see which approaches are most effective and efficient, without directly interacting with patients. Findings could…

Researchers are analyzing medical records from about 7 million people with HIV in South Africa to see how different models of care are working. The goal is to understand which approaches help more people stay on treatment and achieve viral suppression. No new drugs or treatments …

This study looks at medical records from 1.2 million people with HIV in Zambia to understand how different models of delivering HIV treatment are working. Researchers want to see how many people are using these models, how well they control the virus, and what the costs are. No n…