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Could a 7-Day cream replace 4 weeks of treatment for skin cancer?

NCT ID NCT05381597

Recruiting now Disease control Sponsor: Boston University Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a combination cream (5-fluorouracil plus calcipotriene) applied for just 7 to 14 days can clear two types of low-risk skin cancer: superficial basal cell carcinoma and squamous cell carcinoma in situ. About 200 adults will receive either the combination cream or the standard 4-week 5-fluorouracil cream. Researchers will check if the cancer is gone at 3 months and again at 3 years, and also track any pain during treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
combination cream of 5-fluorouracil and calcipotriene
What this could lead to
If it works, this could offer a shorter, more convenient cream treatment for certain skin cancers, reducing treatment time from 4 weeks to 1-2 weeks.
What could go wrong
This is a mid-stage trial with only 200 participants. The combination cream is not yet approved for these cancers, and results may not apply to all skin cancer types or locations.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

squamous carcinoma in situ Squamous Intraepithelial Lesions superficial multifocal basal cell carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SQUAMOUS CELL CARCINOMA IN SITU SUPERFICIAL BASAL CELL CARCINOMA

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Boston Medical Center Dermatology Clinic

    RECRUITING

    Boston, Massachusetts, 02118, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

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