Boston University

This study tests a new combination of five oral drugs (bedaquiline, delamanid, levofloxacin, linezolid, and clofazimine) for treating multidrug-resistant tuberculosis (MDR-TB). The goal is to see if a shorter treatment course (16 to 40 weeks) can effectively cure the infection wi…

This study tests whether a trauma-informed program called Strength at Home works better than the usual state-approved program for reducing intimate partner violence. About 800 men who are court-ordered to attend such programs, along with their partners, will take part. Researcher…

This study compares a custom 3D-printed titanium mesh frame to a standard frame made during surgery for dental bone grafting. Thirty adults needing bone augmentation for dental implants will be randomly assigned to one of the two methods. The goal is to see if the 3D-printed fram…

This early-phase study tests whether a single injection of pramlintide, a diabetes drug, can temporarily increase levels of Alzheimer's-related proteins in the blood, potentially revealing early signs of the disease. Researchers will measure changes in beta-amyloid and tau protei…

This study is testing whether biomarkers found in blood and airway samples can help predict lung cancer in people with suspicious lung nodules. Researchers will collect samples from 85 high-risk smokers and compare them to standard imaging results. The goal is to improve how doct…

This study is testing a new, non-invasive imaging technique called spatial frequency domain imaging (SFDI) to measure skin thickness in people with scleroderma, an autoimmune disease that causes skin hardening. Currently, doctors assess skin fibrosis by pinching the skin, which i…

This study tests whether text reminders, commitment pledges, and planning prompts can help men who have sex with men stay on PrEP, a daily pill that prevents HIV. About 106 men in South Africa who are just starting PrEP will either get standard care or these extra nudges. The goa…

This study tests whether a home-based physical activity program, using a Fitbit and coaching sessions, can help people with HIV who drink heavily increase their daily steps and reduce their alcohol intake. The trial involves 222 participants in the U.S. who are low-active and dri…

This study tests a telehealth program called MCBMAP that combines counseling and skills training to help people with HIV reduce chronic pain and unhealthy drinking. The program is delivered entirely through video calls and online materials, making it easier for participants to jo…

This study is trying to find ways to diagnose chronic traumatic encephalopathy (CTE) in living people. Right now, CTE can only be confirmed after death. Researchers will study 350 former college and professional football players, using memory tests and other biomarkers. The goal …

This study is looking for the genetic causes of bicuspid aortic valve disease, a common heart condition where the aortic valve has two flaps instead of three. Researchers will analyze DNA from 11,000 participants, including patients and their relatives, to find gene changes linke…

This study is looking for early signs of lung cancer in people at high risk, such as older smokers or those with COPD. Researchers will collect blood and airway samples from 665 participants to find biomarkers that could predict lung cancer before symptoms appear. The goal is to …

This study gathers genetic and health information from over 6,400 people with bicuspid aortic valve, a common heart defect. Researchers aim to find the genes responsible for the condition and why some patients later develop serious aortic disease. No treatment is given; the goal …

This study observes over 15,000 HIV patients in Malawi to see how different ways of delivering HIV treatment (like group visits or community pick-up points) affect viral suppression, patient satisfaction, and clinic efficiency. Researchers surveyed patients and providers at 12 he…

This study surveys 771 adults with HIV in Zambia who have started or restarted antiretroviral therapy (ART) within the last six months. Researchers want to learn what services and support patients prefer during this critical early period, when many drop out of care. The goal is t…

This study looks at different ways to deliver HIV treatment in Zambia to see which methods work best for patients and clinics. Researchers will survey over 8,000 patients and healthcare providers at 12 health facilities. The goal is to help policymakers make better decisions abou…

This observational study is tracking over 15,500 people with HIV at 24 healthcare facilities in South Africa. Researchers are comparing different ways of delivering HIV treatment and care to see which models work best for patients and healthcare providers. The study looks at vira…

This study surveys about 1,100 adults in South Africa who have recently started or restarted HIV treatment. The goal is to understand what services and support they need to stay in care during the first six months, a time when many patients drop out. Results will help design bett…