POST-TRAUMATIC STRESS DISORDER

This study tests whether MDMA, combined with a type of talk therapy called Acceptance and Commitment Therapy (ACT), can help treat post-traumatic stress disorder (PTSD) in military service members. Participants receive either a full or low dose of MDMA during therapy sessions. Th…

This pilot study will test a program that combines a trauma-focused therapy (STAIR) with peer-led HIV prevention (PrEP) support for transgender and nonbinary people who have experienced violence. The goal is to see if this combined approach is acceptable, feasible, and helps impr…

This study tests whether a gentle brain stimulation technique called tDCS can make a standard talk therapy for PTSD work better. Military personnel and veterans with both PTSD and a history of mild to moderate traumatic brain injury will receive five weekly sessions of written ex…

This pilot study tests a version of cognitive processing therapy (CPT) that has been adapted to also address stress from lived experiences, such as discrimination or identity-related challenges. The trial enrolls sexual and gender minority adults with PTSD who report distress fro…

This early-stage trial at the University of Chicago tests whether Adderall, a drug used for ADHD, can improve social interactions in people with PTSD. About 40 adults aged 18-65 will receive either Adderall or a placebo and rate their conversations. The goal is to see if this dru…

This study tests whether a stellate ganglion block—a local anesthetic injection near nerves in the neck—can improve sleep and reduce stress in people with PTSD. Sixty adults with PTSD will receive two injections two weeks apart, and their sleep will be tracked with a smart ring f…

This Phase 2 study tests whether the antidepressant vilazodone can safely reduce PTSD symptoms in 200 active-duty service members, veterans, and civilians. Participants receive either vilazodone or a placebo for 12 weeks, with symptom severity measured using a standard PTSD scale…

This study tests whether a therapy that uses MDMA (the active ingredient in ecstasy) can safely reduce post-traumatic stress symptoms in frontline healthcare workers and first responders. About 30 participants will receive the drug alongside talk therapy sessions. The goal is to …

This study tests whether combining repetitive transcranial magnetic stimulation (rTMS) with expressive writing can reduce post-traumatic stress symptoms in adults. Forty-five participants who have experienced a traumatic event will be split into three groups: rTMS before writing,…

This study explores whether aquatic therapy can help veterans with PTSD. Fifty participants will receive 16 weeks of one-on-one sessions in a warm pool, followed by 16 weeks of group exercises. Researchers will measure changes in PTSD symptoms, sleep, and quality of life to see i…

This study looks at whether adding cannabis to standard talk therapy can help veterans with PTSD feel less anxious, depressed, or suicidal. About 280 veterans who have used cannabis before but not recently will take part. Researchers will track changes in PTSD symptoms, brain act…

This pilot study will test a new type of talk therapy called ACT-SHARE for veterans who have both PTSD and alcohol problems and are struggling with conflict in their romantic relationships. The therapy aims to help veterans manage difficult thoughts and feelings and take actions …

This study tests a brain-training method called neurofeedback to see if it can help people with obsessive-compulsive disorder (OCD) and post-traumatic stress symptoms feel better overall. Twenty adults on a therapy waitlist will try the training, and researchers will check for ch…

This study tests whether a wrist-worn biosensor can detect changes in the body's stress response during ketamine-assisted therapy for PTSD. Five adults will wear the device before, during, and after therapy sessions. The goal is to see if a specific pattern of nervous system acti…