Could adderall help PTSD patients connect better?
NCT ID NCT07664631
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-stage trial at the University of Chicago tests whether Adderall, a drug used for ADHD, can improve social interactions in people with PTSD. About 40 adults aged 18-65 will receive either Adderall or a placebo and rate their conversations. The goal is to see if this drug offers a new option for the many PTSD patients who don't get better with current treatments.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- mixed amphetamine salts (Adderall)
- What this could lead to
- If it works, this could point toward a new way to ease social difficulties in PTSD, offering an alternative for people who don't respond to standard treatments.
- What could go wrong
- This is a very early Phase 1 trial with only 40 people, so results may not apply widely. Adderall can cause side effects like increased heart rate, anxiety, or insomnia, and may not improve PTSD symptoms overall.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
University of Chicago
Chicago, Illinois, 60637, United States
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Other studies related to the condition(s) this trial covers.
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