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Ketamine's Suicide-Fighting secret under the microscope

NCT ID NCT05786066

Recruiting now Knowledge-focused Sponsor: Yale University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study at Yale University is testing whether blocking a specific brain receptor (AMPA) stops ketamine from reducing suicidal thoughts. Thirty adults with depression, bipolar disorder, or PTSD who have current suicidal thoughts will receive either perampanel (an AMPA blocker) or a placebo before a ketamine infusion. Researchers will measure changes in suicidal ideation and depression 24 hours later to understand how ketamine works in the brain.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Perampanel and Ketamine
What this could lead to
If it works, this could reveal how ketamine reduces suicidal thoughts, potentially leading to better treatments for depression and suicide prevention.
What could go wrong
This is a small, early-phase study with only 30 participants, so results may not apply widely. The drug perampanel may cause side effects like dizziness or drowsiness.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

bipolar disorder depressive disorder major depressive disorder post-traumatic stress disorder Suicidal Ideation Suicide

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BIPOLAR DISORDER DEPRESSIVE DISORDER MAJOR DEPRESSIVE DISORDER POST-TRAUMATIC STRESS DISORDER SUICIDAL IDEATION

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • VA Connecticut Healthcare System

    RECRUITING

    West Haven, Connecticut, 06516, United States

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