Simple breath test may predict therapy success for anxiety disorders

NCT ID NCT05467683

Recruiting now Knowledge-focused Sponsor: Jasper A. Smits Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is testing whether a carbon dioxide (CO2) challenge can predict which patients with anxiety, OCD, PTSD, or panic disorder will not respond to exposure-based therapy. Researchers will enroll 600 adults and measure their reaction to breathing CO2-enriched air before starting 12 weeks of therapy. The goal is to see if this easy test can help clinicians decide whether to recommend exposure therapy or alternative treatments.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could give doctors a simple test to decide whether exposure therapy is likely to work for a patient, saving time and improving treatment choices.
What could go wrong: This is an observational study, not a treatment trial. The biomarker may not prove accurate enough for clinical use, and results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

generalized anxiety disorder obsessive-compulsive disorder panic disorder post-traumatic stress disorder social phobia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GENERALIZED ANXIETY DISORDER OBSESSIVE-COMPULSIVE DISORDER PANIC DISORDER POST-TRAUMATIC STRESS DISORDER SOCIAL ANXIETY DISORDER

Contacts and locations

Locations

Boston University
RECRUITING

Boston, Massachusetts, 02215, United States
The University of Texas at Austin
RECRUITING

Austin, Texas, 78712, United States

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