GENERALIZED ANXIETY DISORDER

This study tests whether using a person's genetic information to guide medication choices leads to better recovery for people with mood, anxiety, or psychotic disorders. Over 2,500 participants will receive either standard care or personalized medication advice based on their gen…

This study tests a new way of caring for new mothers and their babies together, called MOMI PODS. It focuses on moms who had heart or mental health problems during pregnancy. The goal is to see if this coordinated care model improves health and reduces risks like postpartum depre…

This study compares two care models for treating anxiety in 556 children and teens aged 8-17. In stepped care, everyone starts with internet therapy and gets in-person help only if needed. In stratified care, participants are assigned to internet or in-person therapy based on the…

This study is testing whether a computer-delivered cognitive behavioral therapy (CBT) program can help people who have both an anxiety disorder and alcohol use disorder. The program teaches skills like breathing control and problem solving to break the cycle of negative feelings …

This study tests whether community health workers can help adults with chronic illnesses get up-to-date on COVID-19 and flu vaccines. Participants receive up to three counseling sessions in English or Spanish to address their vaccine concerns. The goal is to reduce health dispari…

This Phase 2 trial tests whether a single injection of RE104 can reduce anxiety symptoms in 64 adults with generalized anxiety disorder, compared to a placebo. Participants receive one dose and are followed for four weeks to measure changes in anxiety severity using a standard ra…

This study tests whether adding a computer task called gaze-contingent music reward therapy (GCMRT) to standard cognitive behavioral therapy (CBT) helps reduce anxiety in children aged 8 to 17. In GCMRT, children look at faces on a screen while pleasant music plays or stops depen…

This study tests whether a single dose of the experimental drug SYT-510 can reduce anxiety-related brain activity and behavior in 24 adults with generalized anxiety disorder. Participants will receive either the drug or a placebo, then switch after a washout period. The goal is t…

This study tests whether giving cognitive behavioral therapy (CBT) in person, via video, or a mix of both works best for children aged 5-18 with anxiety or OCD. About 500 kids will be randomly assigned to one of three delivery methods. The goal is to find out which approach impro…

This study tests whether group metacognitive therapy works as well as individual therapy for people with generalized anxiety disorder. 64 adults will be randomly assigned to either 10 weekly group sessions or 10 weekly individual sessions. The goal is to see if the group format c…

This study is testing a self-guided internet program called Velibra for people with panic disorder, social anxiety, or generalized anxiety disorder who are on a waitlist for treatment. The program uses cognitive behavioral therapy techniques over six weeks. Researchers want to se…

This study compares a blended group therapy (online and in-person sessions) to standard in-person group therapy for adults with anxiety or depression. About 144 participants will receive 16 weeks of treatment. The goal is to see if the blended approach works as well and is accept…

This study tests whether an 8-week mindful self-compassion program can reduce symptoms of anxiety and depression. It compares attending the program in person versus through videoconference. The study involves 80 adults diagnosed with anxiety disorders or major depression who also…

This study tests whether combining a gentle brain stimulation technique (tDCS) with cognitive-behavioral therapy (CBT) can reduce repetitive negative thinking in adults with generalized anxiety disorder or depression. About 85 participants will receive either real or sham tDCS du…

This study is developing and testing a new internet-delivered cognitive behavioral therapy (ICBT) program for children and teens aged 8-17 with anxiety disorders. The 12-week program, guided by a therapist, uses exposure therapy to help young people face their fears. Researchers …

This study tests a new, non-invasive treatment for people with generalized anxiety disorder who haven't gotten better with standard medications. The treatment uses low-intensity focused ultrasound to gently stimulate a deep brain area linked to anxiety, called the amygdala. 48 ad…

This study is testing two different ways of delivering intensive cognitive behavioral therapy (CBT) to veterans with PTSD and anxiety disorders. One format is individual therapy over two weeks, and the other is group therapy over two days. Both are compared to standard care. The …

This study tests an experimental drug called ITI-1284 for people with generalized anxiety disorder (GAD) whose current treatment isn't working well enough. About 705 adults will receive either ITI-1284 or a placebo added to their usual therapy. The goal is to see if the drug safe…

This study tests whether a daily tablet called ITI-1284, taken under the tongue, can help people with generalized anxiety disorder whose current treatments aren't working well enough. About 570 adults will receive either the drug or a placebo, and researchers will measure changes…

This study tests a new medication called crisugabalin for people with generalized anxiety disorder. About 216 Chinese adults will receive either crisugabalin, a placebo, or an existing drug (venlafaxine) for 8 weeks. The goal is to see if crisugabalin reduces anxiety symptoms bet…

This study looks at whether combining two common therapy techniques—changing negative thoughts and practicing detached mindfulness—works better than using them alone for people with anxiety or depression. Researchers will compare the effects of each technique and their order. The…

This study tests whether a parent-only therapy (SPACE) can reduce anxiety in teens, compared to a parent education support group. About 108 adolescents with anxiety disorders will participate. Parents attend 12 weekly sessions, and researchers measure teen anxiety symptoms before…

This study tests a digital program called UKADO for people waiting for face-to-face therapy for depression or anxiety. About 312 adults will try different versions of the program—some focused on problems, others on strengths—with or without human support. The goal is to see which…

This study looks at a telephone-based program called SUSTAIN that helps older adults (65+) manage depression, anxiety, and chronic pain. Participants receive brief phone assessments and care management over 12 weeks. Researchers want to see what factors influence treatment succes…

This study tests whether a non-invasive brain stimulation method called continuous theta burst stimulation (cTBS) can reduce anxiety in people with generalized anxiety disorder (GAD). Forty participants will be randomly assigned to receive either real or sham (placebo) stimulatio…

This study compares Swedish massage to light touch therapy in 46 adults with generalized anxiety disorder. Participants receive twice-weekly sessions for six weeks, and brain scans measure changes in anxiety-related networks. The goal is to see if touch therapies can reduce anxie…

This early-phase trial is testing whether a generative AI chatbot called Therabot-CALM is usable and acceptable for people with cannabis use disorder who also have anxiety or depression. Fifteen participants will use the app for 4 weeks and give feedback through interviews and su…

This study looks at how the brains of children with anxiety disorders work differently from healthy children. Researchers will use brain scans and thinking tasks to track changes over a year, before and after standard treatments like therapy or medication. The goal is to find pat…

This study looks at how exercise training impacts blood vessel function in people with PTSD or generalized anxiety disorder, compared to healthy individuals. Researchers want to understand if harmful substances called oxidants play a role in blood vessel damage. The study involve…

This study is testing whether a carbon dioxide (CO2) challenge can predict which patients with anxiety, OCD, PTSD, or panic disorder will not respond to exposure-based therapy. Researchers will enroll 600 adults and measure their reaction to breathing CO2-enriched air before star…

This study tests whether real-time brain scans (fMRI) can help young adults with anxiety learn to regulate their emotions better. Participants will practice reappraising negative thoughts while seeing their own brain activity. The goal is to understand which brain areas are invol…

This study looks at whether a single session of a brain stimulation technique called rTMS can change heart activity in women who have had multiple pregnancy losses and also have anxiety. Forty-six women will receive either real or fake stimulation while their heart rate is monito…

This study is looking at how environmental factors in cities—like air pollution, noise, and lack of green space—affect people with depression, anxiety, or alcohol use disorder. Researchers will have 680 participants wear smartwatches to track heart rate, activity, and other body …

This study explores whether a non-invasive brain stimulation technique called rTMS can change heart activity in women who have had multiple pregnancy losses and also suffer from anxiety. Fifty-five women will receive six different intensities of stimulation while their heart rate…

This study looks at how cannabis ads that claim to help with anxiety or depression affect what people buy. About 2,000 light-to-moderate cannabis users with mild to severe anxiety or depression will shop in a realistic online store. Some see ads with mental health claims, others …

This study is a large survey of up to 20,000 adults with conditions like depression, anxiety, or borderline personality disorder. Researchers will ask about medical history and symptoms to see who might qualify for future industry-sponsored clinical trials. The goal is to make it…

This study tests an experimental drug to see if it can fix brain patterns linked to avoiding rewards in people with major depression or anxiety. About 112 unmedicated adults will have brain scans and do decision-making tasks. The goal is to understand how the drug works, not to c…

This study is testing a new family-based program (Fam-AID) for teens aged 13-21 who are getting treatment for substance use and also have anxiety or depression. The program adds extra support for mental health and family involvement to their usual care. Researchers want to see if…

This study aims to understand why some people get stuck in repetitive negative thinking, common in depression and anxiety. Researchers will compare brain activity in 50 patients and 50 healthy volunteers using a harmless brain-imaging device during emotion tasks. The goal is to u…

This study looks at how different exercise programs affect blood vessel function in people with PTSD or generalized anxiety disorder, compared to healthy individuals. Researchers will measure changes in arm and leg blood vessel dilation after 10 weeks of strength training. The go…

This study looks at how exercise affects brain markers linked to anxiety. Thirty adults with anxiety disorders will follow a 4-week virtual exercise program. Researchers will measure specific brain chemicals from blood samples to understand the biological changes behind exercise'…

This study tests whether a device called rTMS, which uses magnetic pulses to temporarily change brain activity, can alter how people with anxiety respond to fearful situations. Researchers will measure brain signals and reactions in 80 adults who recently started anxiety treatmen…

This study uses transcranial magnetic stimulation (TMS) to map brain circuits in 180 adults with depression, OCD, anxiety, or schizophrenia. Participants receive accelerated TMS over two days while completing behavioral tests and questionnaires. The goal is to understand which br…

This study looks at how mindfulness-based stress reduction (MBSR) affects the brains of 150 adults with generalized anxiety disorder. Participants will be randomly assigned to either an 8-week MBSR program or a stress education class. Researchers will use brain scans and other te…

This study follows up to 10,000 medical students in Orléans, France, for up to 22 years to understand what puts them at risk for depression and other mental health issues. Participants fill out an annual online questionnaire. The goal is to identify early warning signs so that fu…

This study looks at how stress and anxiety affect learning and decision-making. Researchers will have participants do tasks like putting a hand in ice water or warm water, then measure how they value rewards and predict emotions. The goal is to understand the link between stress,…

This study looks at how different exercise programs affect blood vessel function in people with PTSD or generalized anxiety disorder. Researchers will compare moderate versus high intensity exercise in 360 participants. The goal is to see if exercise can improve vascular health, …

This study tests whether a technology called transcranial focused ultrasound (tFUS) can temporarily change brain activity linked to anxiety. Researchers will recruit 40 adults with anxiety disorders who recently started treatment. Participants will undergo brain imaging and then …