GENERALIZED ANXIETY DISORDER

This study tests if a computer-delivered cognitive behavioral therapy can help people who have both an anxiety disorder and alcohol use disorder. The goal is to reduce heavy drinking and delay relapse. If effective, this program could be widely available at low cost. The study en…

This study tests whether delivering cognitive behavioral therapy (CBT) in person, via video, or a mix of both works best for children aged 5-18 with anxiety or OCD. About 500 participants will be randomly assigned to one of three delivery methods. The goal is to find ways to make…

This study looks at whether Swedish massage or light touch therapy can reduce anxiety symptoms and change brain activity in people with generalized anxiety disorder (GAD). 46 adults with GAD will receive either Swedish massage or light touch twice a week for 6 weeks. Before and a…

This study tests an experimental drug called ITI-1284 in adults with generalized anxiety disorder (GAD) who haven't gotten enough relief from current treatments. About 570 participants will receive either ITI-1284 or a placebo added to their usual therapy. The main goal is to see…

This study compares two care models for children and teens aged 8–17 with anxiety disorders. In stepped care, everyone starts with internet therapy and gets in-person therapy only if needed. In stratified care, participants are assigned to internet or in-person therapy based on t…

This study tests whether a new drug called ITI-1284 can help adults with generalized anxiety disorder (GAD) whose current treatment isn't working well enough. About 705 participants will receive either ITI-1284 or a placebo added to their usual anxiety medication. The main goal i…

This study is testing a new internet-based therapy for young people aged 8 to 17 with anxiety disorders. The therapy is a type of talk therapy called cognitive behavioral therapy (CBT), delivered online over 12 weeks. The goal is to see if it reduces anxiety severity and to gathe…

This study tests a gentle, non-invasive brain stimulation method called cTBS to see if it can reduce anxiety in people with Generalized Anxiety Disorder. Forty adults will receive either real or placebo stimulation three times daily for a week. Researchers will use brain scans to…

This study tests whether gentle ultrasound waves aimed at a deep brain area (the amygdala) can reduce anxiety in adults with generalized anxiety disorder who haven't gotten better with standard medications. Forty-eight participants will receive either real or fake ultrasound trea…

This study tests a new medication called crisugabalin for people with generalized anxiety disorder. About 216 Chinese adults will receive either crisugabalin, a placebo, or an existing drug (venlafaxine) for 8 weeks. The goal is to see if crisugabalin reduces anxiety symptoms bet…

This study aims to understand how different parts of the brain's prefrontal cortex control behaviors in people with major depression, obsessive-compulsive disorder, generalized anxiety disorder, or schizophrenia. Participants will receive transcranial magnetic stimulation (TMS) a…

This study is testing whether a carbon dioxide (CO2) breathing challenge can help predict which people with anxiety, OCD, PTSD, or panic disorder will not respond to exposure-based therapy. Researchers will enroll 600 adults aged 18 to 70. The goal is to see if this easy test can…

This study looks at how mindfulness-based stress reduction (MBSR) affects the brains of 150 adults with generalized anxiety disorder. Participants will be randomly assigned to either an 8-week MBSR program or a stress education class. Researchers will use brain scans (fMRI) and o…

This study aims to understand why medical students develop depression and other mental health problems. Researchers will follow up to 10,000 students for up to 12 years each, comparing those who enter medical school with those who do not. Participants fill out yearly online quest…