One shot to ease anxiety? new drug RE104 enters human trial
NCT ID NCT07489651
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This Phase 2 trial tests whether a single injection of RE104 can reduce anxiety symptoms in 64 adults with generalized anxiety disorder, compared to a placebo. Participants receive one dose and are followed for four weeks to measure changes in anxiety severity using a standard rating scale. The study is currently recruiting.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- RE104 for injection
- What this could lead to
- If it works, this could point toward a fast-acting, single-dose treatment option for generalized anxiety disorder.
- What could go wrong
- This is an early Phase 2 trial with only 64 people, so results may not apply broadly. The drug may not reduce anxiety better than placebo, and side effects are still being studied.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Email: •••••@•••••
Locations
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Aim Trials, LLC
RECRUITINGPlano, Texas, 75093, United States
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Atlanta Center for Medical Research
RECRUITINGAtlanta, Georgia, 30331, United States
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Austin Clinical Trial Partners
RECRUITINGAustin, Texas, 78737, United States
Contact Email: •••••@•••••
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BioBehavioral Research Austion
RECRUITINGAustin, Texas, 78759, United States
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Cedar Clinical Research
RECRUITINGDraper, Utah, 84020, United States
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CenExel iResearch, LLC
RECRUITINGDecatur, Georgia, 30030, United States
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Collaborative Neuroscience Research, LLC
RECRUITINGGarden Grove, California, 92845, United States
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Henry Ford Medical Center - Columbus
RECRUITINGNovi, Michigan, 48377, United States
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Inner Space State Street
RECRUITINGOrem, Utah, 84058, United States
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Innovative Clinical Research, Inc.
RECRUITINGLauderhill, Florida, 33319, United States
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Kadima Neuropsychiatry Institute
RECRUITINGLa Jolla, California, 92037, United States
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Lighthouse Psychiatry
RECRUITINGGilbert, Arizona, 85234, United States
Contact Email: •••••@•••••
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Midwest Research Group
RECRUITINGSaint Charles, Missouri, 63304, United States
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NYU-H+C Clinical and Translational Science Institute
RECRUITINGNew York, New York, 10016, United States
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Neuro-Behavioral Clinical Research, Inc.
RECRUITINGNorth Canton, Ohio, 44720, United States
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Open Mind Therapeutics
RECRUITINGSan Francisco, California, 94114, United States
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Preferred Research Partners, Inc.
RECRUITINGLittle Rock, Arkansas, 72211, United States
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Summit Headlands LLC
RECRUITINGPortland, Oregon, 97210, United States
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TRIP Clinic at Psychedelic Science Institute
RECRUITINGSanta Monica, California, 90404, United States
Contact Email: •••••@•••••
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UNM Research Program Psychedelic Therapies
RECRUITINGAlbuquerque, New Mexico, 14624, United States
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University of South Florida
RECRUITINGTampa, Florida, 33613, United States
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Uptown Research Institute
RECRUITINGChicago, Illinois, 60640, United States
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