Pumping iron for mental health: study tests if exercise boosts blood vessels in PTSD and anxiety

NCT ID NCT04916340

Recruiting now Knowledge-focused Sponsor: Virginia Commonwealth University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at how different exercise programs affect blood vessel function in people with PTSD or generalized anxiety disorder, compared to healthy individuals. Researchers will measure changes in arm and leg blood vessel dilation after 10 weeks of strength training. The goal is to understand if exercise can help reduce the higher risk of heart disease seen in people with these mental health conditions.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: exercise training (muscular strength and muscular fitness programs)
What this could lead to: If successful, this could show that specific exercise programs improve blood vessel health in people with mental health disorders, pointing toward simple, drug-free ways to reduce heart disease risk.
What could go wrong: This is an early-stage observational study, not a treatment trial. It may find no clear benefit, and results may not apply to people on medications or with other health conditions.

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Conditions

The condition(s) this trial relates to.

cardiovascular disorder generalized anxiety disorder peripheral vascular disease post-traumatic stress disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PERIPHERAL VASCULAR DISEASES

Contacts and locations

Locations

Virginia Commonwealth University
RECRUITING

Richmond, Virginia, 23298, United States

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