Virginia Commonwealth University

This study tests a program to help Black women with breast cancer follow their prescribed treatment plan, including chemotherapy and hormone therapy. Researchers will compare the program to standard care in 250 participants to see if it improves treatment start, reduces delays, a…

This study tests whether adding the oral drug zanubrutinib to standard chemotherapy (R-CHOP) helps people with a specific type of lymphoma (DLBCL) that has certain gene changes. About 21 adults with these mutations will receive the combination. The goal is to see if more patients…

This early study tests whether adding a freezing spray (cryospray) to usual treatments can prevent the windpipe from narrowing again in people with benign airway stenosis. About 12 adults with significant narrowing will receive the spray during a standard procedure. The main goal…

This early-stage trial tests an experimental drug called GZ17-6.02 in 30 men with castration-resistant prostate cancer that has worsened despite hormone therapy. The main goal is to see if the drug can delay cancer growth for at least 6 months. Researchers will also measure chang…

This study is for adults aged 70 or older, or those who are frail, with advanced non-small cell lung cancer that has a low PD-L1 score. The goal is to see if using a reduced dose of chemotherapy together with an immunotherapy drug (anti-PD-1) causes fewer side effects that force …

This study tests whether adding two antibiotics (ciprofloxacin and metronidazole) plus aspirin to standard chemotherapy can improve outcomes for people with stage IV colorectal cancer. About 97 participants will receive either chemo alone or chemo plus the microbiome therapy. The…

This study tests a new non-surgical treatment for intermittent exotropia, a condition where one eye turns outward. The therapy uses a special headset to show different images to each eye, training them to work together. Researchers will enroll 20 children aged 4-7 to see if this …

This study tests whether a low-dose anti-inflammatory drug called colchicine can safely reduce inflammation in 30 adults who cannot take statins due to side effects. Participants will take colchicine for four weeks, and researchers will monitor side effects and measure changes in…

This study tests whether giving radiation for breast cancer in only 3 treatments over 1.5 days is safe and works as well as longer schedules. It involves 170 women aged 45-79 with early-stage breast cancer who have had a lumpectomy. The main goal is to check for side effects and …

This study tests whether capsules containing bacteria from healthy people can safely reduce alcohol cravings and drinking in adults with alcohol-related liver disease and cirrhosis. About 80 participants will receive either the bacteria capsules or a placebo. The goal is to see i…

This study is testing whether a heart medication called sacubitril-valsartan is tolerable and feasible for young adult cancer survivors (diagnosed at or before age 39) who have early-stage heart failure (Stage B) without symptoms. The goal is to see if the drug can help prevent t…

This early-phase study tests whether a daily pill called olutasidenib can safely help adults with a specific type of acute myeloid leukemia (IDH1-mutant AML) stay in remission after standard chemotherapy. About 15 participants will take the drug for at least 4 months while doctor…

This study tests whether giving a specific chemotherapy regimen (mFOLFOX) along with a short course of radiation before surgery can help people with rectal cancer live longer without the cancer coming back. About 54 adults with resectable rectal cancer will receive this treatment…

This study tests whether an oral medication (azacitidine) can help prevent acute myeloid leukemia from coming back in patients who are in remission but cannot receive a stem cell transplant due to racial or socioeconomic reasons. About 12 adults will take the drug for at least 4 …

This study looks at whether it's better to do bone grafting right after pulling a back tooth or to wait. The goal is to keep enough bone for a dental implant while reducing pain and cost. About 40 adults will be followed to see how their quality of life and bone health compare be…

This study tests two drugs, neratinib and valproate, in people with advanced solid tumors that have not responded to standard treatments. The goal is to find the best dose and see if the combination can shrink tumors, especially in cancers with a RAS mutation. About 83 adults wil…

This study tests whether a skin patch containing rotigotine, a drug already approved for Parkinson's disease, can help people with cocaine use disorder cut down on cocaine use and improve thinking skills. About 40 adults aged 25-70 with moderate to severe cocaine use disorder wil…

This study looks at whether a urine test (called CXCL10) can catch kidney transplant rejection that a standard blood test might miss. About 50 adults who need a kidney biopsy will provide urine samples. Researchers will compare the urine test results to the blood test and biopsy …

This study tests a hospital-based program called Bridging the Gap (BTG) for adults treated for violent injuries like gunshot wounds. The goal is to see if BTG reduces future violence, firearm use, and re-injury. Researchers will follow 616 participants to compare outcomes between…

This study is testing a low-cost training program for doctors and their patients with chronic pain. The program teaches team-based skills to manage pain without relying on opioids. About 1,188 participants (patients aged 14–80 and their doctors) will take part to see if the progr…

This study tests if a home-based exercise program can improve heart and lung fitness in men with prostate cancer who are receiving hormone therapy (androgen deprivation therapy). The study will compare 60 men who exercise at home to those who receive only healthy living education…

This study tests whether a drug called anakinra can reduce inflammation and help the heart respond better to inotropes (medicines that strengthen heart contractions) in people with end-stage heart failure. About 20 adults on stable inotrope therapy will receive anakinra for 3 mon…

This study tests a technique called heart rate variability biofeedback, which uses breathing exercises to help people with long-lasting symptoms after a mild concussion. The goal is to reduce issues like headaches, dizziness, memory problems, and mood changes. The trial includes …

This study tests a 24-week remote therapy for adults with anorexia who recently completed intensive treatment. Participants receive either a therapy focused on improving positive emotions and reward processing or standard education and behavioral support. The goal is to see if th…

This study tests a computer program called C-SCAT that helps adolescents and young adults with cancer track and manage their symptoms. About 126 participants will either use the tool or receive usual care. The goal is to see if the tool boosts their confidence and ability to hand…

This study is testing a program that helps people with obesity who are waiting for a kidney transplant lose weight. The program includes education on healthy eating and tools to make better lifestyle choices. About 30 adults will take part to see if the program improves their qua…

This study tests whether adding the drug valbenazine to standard botox injections can better control neck muscle spasms and pain in people with cervical dystonia. About 20 adults aged 18-75 with moderate neck dystonia will take valbenazine pills for 12 weeks while continuing thei…

This study tests a special lifestyle program for women ages 18-25 with a BMI between 25 and 50. The goal is to see if it helps reduce body fat, waist size, and signs of inflammation better than standard weight loss advice. Participants will be followed for 12 months to track chan…

This study tests a program called "Mindful Moms" to see if it can improve mood and health in pregnant women with depressive symptoms. About 200 pregnant women with mild to moderate depression will either take the mindfulness program or attend group education workshops. The goal i…

This early study looks at whether breast cancer patients can use azelaic acid cream twice a day during radiation to help manage skin irritation. About 33 adults with darker or sun-sensitive skin who are getting radiation will try the cream. The goal is to see if it's practical an…

This study compares two virtual programs for adults with brain tumors who have trouble with thinking or memory. One program combines cognitive rehab with mindfulness training; the other offers educational videos on brain health. Participants attend 8 weekly sessions, complete sur…

This study looks at the best way to protect the roof of the mouth after a gum graft. About 56 adults will try one of three different protective dressings. The goal is to find which method causes the least pain, swelling, and bleeding during healing.

This study is testing a mobile app designed to help cancer survivors manage pain and other symptoms after finishing treatment. About 25 adults who have completed cancer treatment and still have pain will use the app for several weeks. The goal is to see if the app is easy to use …

This study compares two methods of controlling a prosthetic arm for adults with below-elbow limb loss. One method uses signals from two muscles, while the other uses signals from several muscles to better understand the user's intended movement. The goal is to see which method is…

This study looks at how different types of exercise affect blood vessel function in healthy people and those with PTSD or generalized anxiety disorder. Researchers will measure changes in blood flow and artery dilation. The goal is to understand if exercise can help improve vascu…

This study looks at how exercise training impacts blood vessel function in people with PTSD or generalized anxiety disorder. Researchers want to understand if harmful substances in the blood (oxidants) play a role. The study involves 720 adults who are otherwise healthy and will …

This study aims to understand how people with a leg amputation move around outside their homes, including both walking and using wheelchairs or scooters. Researchers will track 50 participants for 10-21 days using GPS and activity monitors, along with questionnaires about quality…

This study looks at how the heart's left atrium works during exercise after a procedure called catheter ablation for paroxysmal atrial fibrillation (a type of irregular heartbeat). Researchers will use special MRI scans taken while people exercise to measure changes in heart func…

This study is testing an online tablet-based tool that asks children ages 3 to 7 to copy shapes on a touch screen. The goal is to see if this digital version can quickly and automatically identify kids who may need extra help with prewriting skills, replacing slower, paper-based …

This study looks at how long-term e-cigarette use impacts the health of small blood vessels (microvascular health) in young adults aged 18 to 29. Researchers will measure blood vessel function in frequent e-cigarette users compared to non-users. The goal is to understand potentia…

This study looks at how a gentle, non-invasive brain stimulation technique can change the way people learn and adapt their movements. Researchers will test 60 right-handed adults aged 18 to 40 to see if stimulation improves how they reach for targets. The goal is to better unders…

This study is testing whether a robotic device can safely and easily monitor blood flow in the brains of 30 adults with severe traumatic brain injury. The device uses ultrasound through the temple and is designed to work automatically for long periods. Researchers want to see if …

This study looks at how the brains of teenagers with Postural Tachycardia Syndrome (POTS) process what they see. Researchers will use brain scans to compare brain activity in teens with POTS and healthy teens. The goal is to learn more about how different parts of the brain commu…

This study looks at whether it is safe and possible to do an exercise stress MRI while people with a specific type of pacemaker (left bundle branch area pacemaker) exercise on a bike. About 20 adults who already have this pacemaker will be monitored at rest and during light exerc…

This study is testing whether a program called FearLess is practical and well-liked by people with primary malignant brain tumors and their caregivers. The goal is to see if the program helps reduce the intense fear of the cancer coming back. About 112 participants will be recrui…

This study tests whether parents of infants with a fast heart rhythm (tachyarrhythmia) can use a new digital stethoscope to record clear heart tracings (ECGs) at home. About 100 babies under 1 year old will participate. If successful, this technology could help parents monitor th…

This 24-month observational study will follow up to 1000 people with certain types of muscular dystrophy (LGMD, DM2, or late-onset Pompe disease) to see how well specific muscle function tests work over time. Participants will be between 6 and 50 years old and must have a genetic…

This study looks at how different types of exercise affect blood vessel function in healthy people and those with PTSD or generalized anxiety disorder. Researchers will measure changes in blood flow and artery dilation. The goal is to understand if exercise can help improve vascu…

This study looks at how the brain might be involved in POTS, a condition that causes a fast heart rate and dizziness when standing up. Researchers will use brain scans and questionnaires to understand symptoms in 120 teenagers. The goal is to learn more about the condition, not t…

This study tests whether an AI-powered chatbot can teach African American adults about oral cancer better than a standard educational handout. About 60 participants will use either the chatbot or the handout, then take surveys to measure their knowledge, attitudes, and satisfacti…

This study follows 240 adults with NASH-related cirrhosis to find better ways to detect when the liver starts to fail. Researchers will track serious events like internal bleeding, fluid buildup, and confusion. The goal is to improve routine monitoring so doctors can spot problem…

This study tests whether a patient navigation program helps more Black adults who are at high risk for lung cancer complete their lung cancer screening. Researchers will enroll 675 people and track how many get a low-dose CT scan. The goal is to see if having a guide through the …

This study is creating a registry to understand how the immune system responds to BK virus in kidney transplant recipients. Researchers will track 60 adults who have recently developed BK virus after a kidney transplant. The goal is to learn more about the virus and how it intera…

This study looks at how stressful events in childhood may impact heart and blood vessel health later in life. Researchers will measure heart function, blood vessel response, and lung function in 120 people aged 9 to 30. The goal is to understand the connection between early stres…

This study tests a hospital-based program for youth aged 13-17 who have been injured by violence. The goal is to see if the program can reduce future violence and risky behaviors. Researchers will track participants' attitudes, re-injury rates, and other outcomes over time.

This study looks at how the size of small attachments on clear aligners (like Invisalign) affects how well a specific tooth can be moved. About 40 people getting Invisalign treatment will be randomly assigned to one of three attachment sizes. The goal is to find which size works …

This study looks at whether talking to violently injured teens in the hospital can reduce future violence, including firearm use and re-injury. About 300 youth aged 10-17 and their caregivers will take part. Researchers will track incidents, behaviors, and beliefs over time to se…

This study looks at why people with Lewy body dementia (including Parkinson's disease dementia) experience sudden, unpredictable changes in attention and thinking, known as cognitive fluctuations. Researchers will use brain scans, EEG, and thinking tests to measure brain changes …

This study tests whether doing physical activity before a mild brain stimulation technique (HD-tDCS) can lower anxiety more than either approach alone. Researchers will measure anxiety levels and brain blood flow in 29 healthy adults aged 18-50. The goal is to understand how thes…

This study asks transgender and gender-diverse youth aged 15-21 about their experiences and decisions to participate in research. Researchers want to learn what helps or hinders their involvement, so future studies can be more inclusive. The goal is to make research fairer and be…