Virginia Commonwealth University

This study is testing whether a medication delivered through a skin patch can help people with cocaine addiction. The patch, called rotigotine, is already approved for Parkinson's disease. Researchers want to see if it helps reduce cocaine use and improves brain function related …

This study is testing whether adding a combination of two common antibiotics (ciprofloxacin and metronidazole) and aspirin to standard chemotherapy helps people with advanced colorectal cancer. Researchers want to see if changing the bacteria in the gut (the microbiome) can make …

This study is testing two different remote therapy programs to help people maintain their recovery from anorexia nervosa after leaving intensive treatment. Researchers will enroll 90 adults who have recently completed higher-level eating disorder care. Participants will receive 2…

This study is testing whether adding the targeted drug zanubrutinib to standard chemotherapy (R-CHOP) works better for people with an aggressive type of blood cancer called diffuse large B-cell lymphoma (DLBCL) who have specific genetic markers. The trial will enroll about 21 adu…

This study is testing whether a special headset therapy can improve eye alignment in children aged 4-7 with intermittent exotropia, where one eye occasionally drifts outward. Current treatments often involve surgery, with many children needing repeat operations. The therapy invol…

This study is testing a new, intensive lifestyle program designed for young women aged 18-25 who have a body mass index (BMI) between 25 and 50. It will compare this new program to a standard behavioral weight loss program over 12 months. The main goals are to see which approach …

This early-stage study is testing whether an oral medication called GZ17-6.02 can slow the progression of advanced prostate cancer that has become resistant to standard hormone-blocking drugs. The trial will enroll about 30 men whose cancer has worsened despite prior treatments. …

This early study is testing whether adding a freezing spray (cryospray) to standard treatments helps prevent airway narrowing from returning. Researchers will follow 12 adults with benign tracheal stenosis to see if the combined treatment keeps airways more open after 6 months. T…

This study is testing whether a much faster radiation treatment schedule is safe and effective for certain breast cancer patients. Instead of weeks of daily treatments, participants receive three radiation sessions over about two days. Researchers will track side effects, cancer …

This study is testing whether a special training program for doctors and other healthcare providers can help people with long-term chronic pain. The training teaches providers new ways to manage pain without relying as heavily on opioid medications. Researchers will measure if pa…

This study tests a program designed to help Black women with breast cancer better follow their medication and treatment plans. It compares a special support program led by fellow survivors against standard care materials. The goal is to see if better communication with doctors le…

This study is testing a drug called olutasidenib as a long-term 'maintenance' therapy for adults with a specific genetic form of acute myeloid leukemia (AML). The goal is to see if taking this pill for up to two years after finishing standard chemotherapy is safe and can help kee…

This study is testing a new program designed to help overweight or obese patients on the kidney transplant waitlist lose weight. The program combines education, technology tools, and support from a nurse, pharmacist, and dietitian. The goal is to see if this approach is practical…

This early-stage study is testing whether a drug that blocks inflammation (anakinra) can make patients with very advanced heart failure more sensitive to their current heart-stimulating medications (inotropes). The goal is to see if patients can use lower, safer doses of these ri…

This study is testing if a drug that reduces inflammation (anakinra) can prevent heart failure in people who have just had a heart attack. Researchers believe the body's inflammatory response to the heart attack may contribute to future heart weakness. About 84 participants will …

This study is testing if a heart medication called sacubitril/valsartan is safe and practical to use in young adult cancer survivors who have early signs of heart damage from their past cancer treatments. It will involve about 53 participants who had cancer before age 40 and now …

This study is testing whether a lower dose of chemotherapy, when combined with immunotherapy, is safer and easier to tolerate for older or frail adults with advanced lung cancer. The main goal is to see if this gentler approach causes fewer severe side effects that would force pa…

This study is testing whether an oral medication can help prevent relapse in acute myeloid leukemia patients who are eligible for a stem cell transplant but cannot get one due to social or economic barriers. It will enroll 12 adult patients who have achieved remission but face ch…

This study is testing a combination of chemotherapy and short-course radiation given before surgery for rectal cancer. The goal is to better control the cancer and improve survival rates. Some participants who respond very well may avoid surgery altogether and instead be closely …

This study aims to determine whether bone grafting should be done immediately after extracting upper back teeth or delayed until implant placement. Researchers will compare how well each approach preserves jawbone and affects patient comfort. The study involves 40 participants wh…

This study is testing an online version of a tablet-based assessment for young children's prewriting skills. Researchers want to see if this automated tool can reliably identify children who may struggle with the foundational skills needed for writing. The goal is to provide a fa…

This study is testing a new urine test to better detect when a transplanted kidney is being rejected by the body. It aims to see if this test works better than a current blood test that sometimes misses rejection. The study will also check if urine samples can be shipped at room …

This study is testing whether a digital stethoscope can help parents accurately check their baby's heart rhythm at home. It involves 100 infants under 1 year old who are at risk for fast heart rhythms. The goal is to see if this device can provide clear heart recordings, giving p…

This study is testing whether a hospital-based support program can prevent repeat gun violence in adults recently injured by violence. Researchers will compare two groups: one receiving 6 months of counseling and case management, and another receiving basic violence awareness inf…

This study is testing whether a hospital-based program can help prevent future violence among youth who have been injured by violence. Researchers will compare two approaches: one group receives a brief brochure while the other gets intensive case management services for three mo…

This study is exploring a new way to potentially ease anxiety symptoms by combining two non-drug approaches. Researchers are testing if doing physical activity right before a safe, non-invasive brain stimulation treatment makes the anxiety-reducing effects stronger than either me…

This study is testing whether a breathing exercise technique called heart rate variability biofeedback can help reduce persistent symptoms after concussion. The research involves 148 adults, including military veterans and civilians, who have had mild traumatic brain injuries and…

This study is testing a new psychological support program called FearLess, designed to help people with brain tumors and their caregivers manage the fear of the cancer coming back. Researchers want to see if the program is practical, acceptable, and a good fit for participants. T…

This study is testing whether a home-based exercise program can improve fitness and reduce heart disease risk in men with prostate cancer who are undergoing hormone therapy (ADT). Sixty participants will be assigned to either the exercise training group or a healthy living educat…

This study is testing a computer tool designed to help teenagers and young adults with cancer better manage their treatment symptoms. Researchers will compare the tool against standard care for 126 participants who are within their first three months of cancer diagnosis. The main…

This study is testing whether a 12-week prenatal yoga program called 'Mindful Moms' can help reduce depression symptoms in pregnant women, compared to standard prenatal education classes. It will enroll 200 pregnant women who are experiencing depressive symptoms, with a focus on …

This small pilot study is testing whether breast cancer patients can consistently use a topical cream called azelaic acid during their radiation therapy. The main goal is to see if using it at least twice a day is practical and tolerable. Researchers want to learn if this approac…

This study is comparing two ways to control a prosthetic arm to see which one is more intuitive and less mentally demanding for daily tasks. Researchers are testing a newer 'pattern recognition' system against the standard 'direct control' method with 32 adults who have a below-e…

This study is testing a new mobile phone app designed to help cancer survivors manage pain and other symptoms after treatment. The app provides educational messages, tips for talking with doctors, and tools for tracking how you feel. Researchers want to see if the app is easy to …

This study is testing whether giving vitamin D supplements to cancer patients who are deficient can reduce nerve pain caused by a common chemotherapy drug called taxane. About 80 patients scheduled for this chemo will be randomly assigned to either receive prescribed vitamin D or…

This study is testing whether an AI-powered chatbot is a better teaching tool than traditional educational handouts for increasing knowledge about oral cancer. Researchers will enroll 60 African American adults from the Richmond area and randomly assign them to learn from either …

This study aims to understand why people with Lewy body dementia experience sudden, unpredictable changes in their thinking and alertness, known as cognitive fluctuations. Researchers will compare brain scans and other tests from 120 participants, including people with dementia a…

This research study aims to understand how the brain learns and adapts movements. Healthy volunteers will perform reaching tasks in a virtual reality environment while receiving gentle, non-invasive brain stimulation. The goal is to gather basic knowledge about motor control that…

This study aims to understand how the brains of teenagers with Postural Tachycardia Syndrome (POTS) process visual information. Researchers will use brain scans (fMRI) to measure activity in a specific brain region while participants rest and perform a simple task. The goal is to…

This study follows 50 patients with intermittent atrial fibrillation who receive a standard catheter ablation procedure. Researchers will use exercise tests and heart imaging to measure how the heart's pumping function improves during physical activity after treatment. The goal i…

This study aims to understand if a problem in a specific brain area (the periaqueductal gray) is the root cause of Postural Orthostatic Tachycardia Syndrome (POTS) and its common co-occurring pain conditions in adolescents. Researchers will recruit 120 participants, including tee…

This study aims to find out which size of small, tooth-colored bump (called an attachment) works best for moving a specific front tooth when using clear aligners like Invisalign. Researchers will compare three different sizes of these attachments in 40 people undergoing treatment…

This study aims to understand what influences transgender and gender-diverse youth (ages 15-21) when deciding whether to participate in research. Researchers will ask participants about their experiences, barriers, and reasons for joining studies. The goal is to use this informat…

This study aims to better understand how several rare types of muscular dystrophy progress over time. Researchers will observe up to 1,000 participants for two years, tracking their strength, movement, and quality of life using standard tests and questionnaires. The goal is to ga…

This study aims to understand how different types of exercise training affect blood vessel function. It will compare healthy individuals with people who have post-traumatic stress disorder (PTSD) or generalized anxiety disorder (GAD). Researchers will measure blood vessel health …

This study aims to understand how exercise training might improve blood vessel function in people with post-traumatic stress disorder (PTSD) or generalized anxiety disorder (GAD). Researchers will test 720 participants, including healthy individuals and those with these mental he…

This study aims to test a new, safe method for measuring how a specific type of pacemaker (LBBAP) affects the right and left sides of the heart during light exercise. Researchers will use special exercise and imaging tests on 20 patients who already have this pacemaker. The goal …

This study aims to understand how people with leg amputations move around their communities using both prosthetic limbs and wheelchairs. Researchers will track 50 participants' daily movements using GPS and activity monitors for 10-21 days, while also asking questions about their…

This study is testing a new robotic device that monitors blood flow in the brain of patients with severe head injuries. It aims to see if using this device for several hours a day is safe, comfortable for patients, and practical for doctors and nurses to use. The goal is to gathe…

This study aims to understand how regular e-cigarette use affects the health of small blood vessels in young adults. Researchers will compare 44 participants—some who vape regularly and some who don't—using non-invasive tests to measure blood flow. The goal is to gather knowledge…

This study aims to better understand how kidney transplant patients' immune systems respond to BK virus infection, which can damage the new kidney. Researchers will observe 60 adult transplant recipients who have recently developed BK virus in their blood. The study will measure …

This study aims to understand how different types of weightlifting exercise affect blood vessel function. Researchers will compare healthy adults to those with post-traumatic stress disorder (PTSD) or generalized anxiety disorder (GAD). Participants will complete various tests an…

This study aims to understand how stressful childhood experiences affect heart and blood vessel health later in life. Researchers will measure heart function, blood vessel health, and lung capacity in 120 young people aged 9-30. The goal is to learn how early stress might lead to…