Virginia Commonwealth University

This study tests whether adding the oral drug zanubrutinib to standard chemotherapy (R-CHOP) helps more people with diffuse large B-cell lymphoma (DLBCL) achieve complete remission. It is for patients whose tumors have certain genetic changes (MYD88, CD79B, NOTCH1 mutations or CD…

This study tests whether adding two antibiotics (ciprofloxacin and metronidazole) and aspirin to standard chemotherapy can help people with stage IV colorectal cancer. About 97 participants will receive either chemo alone or chemo plus the extra drugs. The goal is to see if the c…

This study compares an intensive lifestyle program to standard weight loss advice in 32 women aged 18-25 with a BMI of 25-50. The goal is to see if the intensive program leads to greater reductions in weight, waist size, and body fat, and also improves markers of inflammation and…

This study tests two drugs, neratinib and valproate, together in people with advanced solid tumors that have stopped responding to standard treatments. The goal is to find the safest and most effective dose, and then see if the combination can shrink tumors, especially in cancers…

This study looks at whether it is better to do bone grafting right after pulling a back tooth or to wait. The goal is to keep enough bone for a dental implant later. About 40 adults will take part, and researchers will track their pain, healing, and quality of life using a simple…

This study tests whether a skin patch containing rotigotine, a drug already approved for Parkinson's disease, can help people with cocaine use disorder cut back on cocaine use when combined with standard behavioral therapy. The trial enrolls 40 adults aged 25-70 with moderate to …

This study is testing a treatment plan for people with rectal cancer that can be surgically removed. Participants receive a combination of chemotherapy (mFOLFOX) and a short course of radiation before surgery. The goal is to see if this approach improves the chance of being cance…

This early study tests whether adding a freezing spray (cryospray) to usual treatments can prevent the windpipe from narrowing again in people with benign airway stenosis. About 12 adults with significant narrowing will receive the spray during a standard procedure. The main goal…

This early-stage trial tests an experimental drug called GZ17-6.02 in 30 men with castration-resistant prostate cancer that has worsened despite hormone therapy. The main goal is to see if the drug can delay cancer growth for at least 6 months. Researchers will also measure chang…

This study is for adults aged 70 or older, or those who are frail, with advanced non-small cell lung cancer that has a low PD-L1 score. The goal is to see if using a reduced dose of chemotherapy together with an immunotherapy drug (anti-PD-1) causes fewer side effects that force …

This study tests whether a low-dose anti-inflammatory drug called colchicine can safely reduce inflammation in people who cannot take statins due to side effects. About 30 adults aged 18 to 80 with statin intolerance will take colchicine for four weeks. Researchers will monitor s…

This study tests whether an oral maintenance drug (azacitidine) can help prevent relapse in adults with acute myeloid leukemia (AML) who are in remission but cannot receive a stem cell transplant due to racial or socioeconomic disparities. About 12 participants will take the drug…

This study tests a program to help Black women with breast cancer follow their prescribed treatment plan, including chemotherapy and hormone therapy. Researchers will compare the program to standard care in 250 participants to see if it improves treatment start, reduces delays, a…

This study tests a new non-surgical treatment for intermittent exotropia, a condition where one eye turns outward. The therapy uses a special headset to show different images to each eye, training them to work together. Researchers will enroll 20 children aged 4-7 to see if this …

This study tests whether capsules containing bacteria from healthy people can safely reduce alcohol cravings and drinking in adults with alcohol-related liver disease and cirrhosis. About 80 participants will receive either the bacteria capsules or a placebo. The goal is to see i…

This study is testing whether a heart medication called sacubitril-valsartan is tolerable and feasible for young adult cancer survivors (diagnosed at or before age 39) who have early-stage heart failure (Stage B) without symptoms. The goal is to see if the drug can help prevent t…

This early-phase study tests whether a daily pill called olutasidenib can safely help adults with a specific type of acute myeloid leukemia (IDH1-mutant AML) stay in remission after standard chemotherapy. About 15 participants will take the drug for at least 4 months while doctor…

This study looks at whether a urine test (called CXCL10) can catch kidney transplant rejection that a standard blood test might miss. About 50 adults who need a kidney biopsy will provide urine samples. Researchers will compare the urine test results to the blood test and biopsy …

This study tests a hospital-based program called Bridging the Gap (BTG) for adults treated for violent injuries like gunshot wounds. The goal is to see if BTG reduces future violence, firearm use, and re-injury. Researchers will follow 616 participants to compare outcomes between…

This study looks at the best way to protect the roof of the mouth after a gum graft. About 56 adults will try one of three different protective dressings. The goal is to see which method causes the least pain, swelling, and bleeding during healing.

This study tests a mobile app designed to help cancer survivors manage pain and other symptoms after finishing treatment. Researchers want to see if the app is easy to use and helpful. About 25 adults who have completed cancer treatment and still have pain will try the app for a …

This study tests a training program for healthcare practitioners to help them better treat chronic pain without relying on opioids. About 1,188 patients and their doctors will take part. The program teaches team-based, behavioral approaches to pain management, with the goal of im…

This study tests whether adding the drug valbenazine to standard botox injections can better reduce neck muscle spasms and pain in people with cervical dystonia. About 20 adults aged 18–75 with idiopathic cervical dystonia will receive valbenazine daily for 12 weeks while continu…

This study tests whether giving radiation in 3 treatments over about 1.5 days is safe and works well for women with early-stage breast cancer after a lumpectomy. About 170 women aged 45-79 will take part. The goal is to see if this faster approach causes fewer side effects and ke…

This study tests if a home-based exercise program can improve heart and lung fitness in men with prostate cancer who are receiving hormone therapy (androgen deprivation therapy). The study will compare 60 men who exercise at home to those who receive only healthy living education…

This study tests whether a drug called anakinra can reduce inflammation and help the heart respond better to inotropes (medicines that strengthen heart contractions) in people with end-stage heart failure. About 20 adults on stable inotrope therapy will receive anakinra for 3 mon…

This study tests a technique called heart rate variability biofeedback, which uses breathing exercises to help people with long-lasting symptoms after a mild concussion. The goal is to reduce issues like headaches, dizziness, memory problems, and mood changes. The trial includes …

This study tests a 24-week remote therapy for adults with anorexia who recently completed intensive treatment. Participants receive either a therapy focused on improving positive emotions and reward processing or standard education and behavioral support. The goal is to see if th…

This study tests a computer program called C-SCAT that helps adolescents and young adults with cancer track and manage their symptoms. About 126 participants will either use the tool or receive usual care. The goal is to see if the tool boosts their confidence and ability to hand…

This study is testing a program that helps people with obesity who are waiting for a kidney transplant lose weight. The program includes education on healthy eating and tools to make better lifestyle choices. About 30 adults will take part to see if the program improves their qua…

This study tests a program called "Mindful Moms" to see if it can improve mood and health in pregnant women with depressive symptoms. About 200 pregnant women with mild to moderate depression will either take the mindfulness program or attend group education workshops. The goal i…

This early study looks at whether breast cancer patients can use azelaic acid cream twice a day during radiation to help manage skin irritation. About 33 adults with darker or sun-sensitive skin who are getting radiation will try the cream. The goal is to see if it's practical an…

This study compares two virtual programs for adults with brain tumors who have trouble with thinking or memory. One program combines cognitive rehab with mindfulness training; the other offers educational videos on brain health. Participants attend 8 weekly sessions, complete sur…

This study tests a hospital-based program for youth aged 13-17 who have been injured by violence. The goal is to see if the program can reduce future violence and risky behaviors. Researchers will track participants' attitudes, re-injury rates, and other outcomes over time.

This study looks at how a gentle, non-invasive brain stimulation technique affects the way people learn and adapt their movements. Researchers will measure how accurately 60 right-handed adults (ages 18-40) reach for targets before and after 20 minutes of stimulation. The goal is…

This study looks at how exercise affects blood vessel function in people with PTSD or generalized anxiety disorder, compared to healthy individuals. Researchers want to understand if harmful substances called oxidants play a role in blood vessel damage. The study involves 720 adu…

This study looks at how the brain might be involved in POTS, a condition that causes a fast heart rate and dizziness when standing up. Researchers will use brain scans and tilt-table tests in 120 teens to see if a specific brain area (the periaqueductal gray) is linked to symptom…

This study follows 240 adults with NASH-related cirrhosis to find better ways to detect early signs of liver decompensation, such as internal bleeding, fluid buildup, or confusion. Researchers will track deaths and complications over time using routine exams and tests. The goal i…

This study looks at whether a new digital stethoscope can help parents of infants with fast heart rates (tachyarrhythmia) record clear heart rhythm readings at home. About 100 babies under 1 year old will take part. The goal is to see if parents can capture high-quality ECG recor…

This study looks at whether it is safe and possible to do an exercise stress test inside an MRI machine for people who already have a special type of pacemaker. About 20 adults with left bundle branch area pacemakers will be asked to exercise on a bike while their heart function …

This study looks at how long-term e-cigarette use impacts the health of tiny blood vessels in the body. Researchers will compare frequent e-cig users (ages 18-29) to non-users using laser imaging and skin tests. The goal is to understand the early effects of vaping on blood vesse…

This study is creating a registry of 60 kidney transplant recipients who have a BK virus infection. Researchers will track how the immune system responds to the virus over time by analyzing blood and urine samples. The goal is to better understand the virus and improve treatment,…

This study looks at what helps or hinders transgender and gender-diverse youth (ages 15-21) from taking part in research. Researchers will ask participants about their experiences and reasons for joining studies. The goal is to make research more inclusive and better represent th…

This study is testing whether a robotic ultrasound device can safely and effectively monitor blood flow in the brains of 30 adults with severe traumatic brain injury. The device is designed to be used automatically for long periods, even in hospitals with little ultrasound experi…

This study looks at whether doing physical activity before a mild, non-invasive brain stimulation can boost anxiety relief more than either alone. Researchers will measure anxiety levels and brain activity in 29 healthy adults aged 18 to 50. The goal is to understand how these tw…

This study is testing a new online version of a tablet-based assessment that checks prewriting skills in children ages 3 to 7. The goal is to make it easier and faster for teachers and clinicians to identify kids who may need extra help before they start formal writing. About 1,0…

This study is testing whether a program called FearLess can help people with brain tumors and their caregivers manage their fear of the cancer coming back. Researchers want to see if the program is practical and well-liked by participants. About 112 patients and caregivers will t…

This study aims to understand how people with a leg amputation move around outside their homes, including both walking and using wheelchairs or scooters. Researchers will track 50 participants for 10-21 days using GPS and activity monitors, along with questionnaires about quality…

This study looks at how the heart's left atrium works during exercise after a procedure called catheter ablation for paroxysmal atrial fibrillation (a type of irregular heartbeat). Researchers will use special MRI scans taken while people exercise to measure changes in heart func…

This study looks at how stressful events in childhood may impact heart and blood vessel health later in life. Researchers will measure heart function, blood vessel response, and lung capacity in 120 people aged 9 to 30. The goal is to better understand the connection between earl…

This study compares two methods of controlling a prosthetic arm for adults with below-elbow limb loss. One method uses signals from two muscles, while the other uses signals from several muscles to better understand the user's intended movement. The goal is to see which method is…

This study looks at how different types of exercise affect blood vessel function in healthy people and those with PTSD or generalized anxiety disorder. Researchers will measure changes in blood flow and artery dilation. The goal is to understand if exercise can help improve vascu…

This study looks at how the brains of teenagers with Postural Tachycardia Syndrome (POTS) process what they see. Researchers will use brain scans to compare brain activity in teens with POTS and healthy teens. The goal is to learn more about how different parts of the brain commu…

This 24-month observational study will follow up to 1000 people with certain types of muscular dystrophy (LGMD, DM2, or late-onset Pompe disease) to see how well specific muscle function tests work over time. Participants will be between 6 and 50 years old and must have a genetic…

This study looks at how different types of exercise affect blood vessel function in healthy people and those with PTSD or generalized anxiety disorder. Researchers will measure changes in blood flow and artery dilation. The goal is to understand if exercise can help improve vascu…

This study tests whether an AI-powered chatbot can teach African American adults about oral cancer better than a standard educational handout. About 60 participants will use either the chatbot or the handout, then take surveys to measure their knowledge, attitudes, and satisfacti…

This study tests whether a patient navigation program helps more Black adults who are at high risk for lung cancer complete their lung cancer screening. Researchers will enroll 675 people and track how many get a low-dose CT scan. The goal is to see if having a guide through the …

This study looks at how the size of small attachments on clear aligners (like Invisalign) affects how well a specific tooth can be moved. About 40 people getting Invisalign treatment will be randomly assigned to one of three attachment sizes. The goal is to find which size works …

This study looks at whether talking to violently injured teens in the hospital can reduce future violence, including firearm use and re-injury. About 300 youth aged 10-17 and their caregivers will take part. Researchers will track incidents, behaviors, and beliefs over time to se…

This study looks at why people with Lewy body dementia (including Parkinson's disease dementia) experience sudden, unpredictable changes in attention and thinking, known as cognitive fluctuations. Researchers will use brain scans, EEG, and thinking tests to measure brain changes …