Virginia Commonwealth University

This study explores how to best help cancer patients, survivors, and their caregivers quit tobacco. Participants can choose between group or one-on-one counseling sessions. The goal is to see if this program is practical and well-received, paving the way for better tobacco cessat…

This phase 2 trial is testing a two-month course of chemotherapy (mFOLFOX) followed by short-course radiation before surgery for people with resectable rectal cancer. The goal is to see if this approach improves the chance of being cancer-free three years later. About 54 particip…

This pilot study tests whether low-dose colchicine, an anti-inflammatory drug already approved for heart disease, is safe and can reduce inflammation in 30 adults who cannot take statins due to side effects. Participants will take either colchicine or a placebo daily for four wee…

This study looks at whether bone grafting right after a molar extraction is necessary or if it can be delayed until the dental implant is placed. Forty adults needing a molar implant will be randomly assigned to get either immediate grafting or delayed grafting. The goal is to se…

This study tests a virtual reality program called Elevate VR for youth aged 13-17 who have been injured through violence. The program uses games and therapy to teach positive coping and goal-setting. Researchers will measure changes in firearm-related risks, violent behavior, and…

This study tests a virtual reality program designed to help adults who have been violently injured avoid future gun violence and re-injury. About 220 people from VCU Health will take part. The program aims to change beliefs and behaviors around gun use through immersive VR scenar…

This study tests a program that helps people with obesity who are waiting for a kidney transplant lose weight. Participants will receive education, a calorie tracking app, a continuous glucose monitor, a weight scale, and a food scale. The goal is to see if this program is practi…

This study tests whether a lower dose of chemotherapy combined with an immunotherapy drug can be a safer and still effective first treatment for older adults (70+) or those who are frail with advanced non-small cell lung cancer. The main goal is to see if fewer people have to sto…

This study tests whether taking oral azacitidine pills for up to six months can help prevent leukemia from returning in patients who are eligible for a stem cell transplant but cannot get one due to racial or socioeconomic disparities. The trial enrolls 12 adults with acute myelo…

This study tests whether capsules containing bacteria from healthy people can safely reduce alcohol cravings and drinking in adults with alcohol-related liver disease and cirrhosis. About 80 participants will receive either the bacteria capsules or a placebo, and researchers will…

This study looks at whether a special lifestyle program can help women ages 18-25 with a BMI between 25 and 50 lose weight and reduce inflammation better than standard weight loss advice. About 32 women will take part over 12 months. The goal is to improve long-term health by tar…

This phase 2 trial tests whether adding two antibiotics (ciprofloxacin and metronidazole) plus aspirin to standard chemotherapy can improve outcomes for people with stage IV colorectal cancer. About 97 participants will receive either chemo alone or chemo plus the microbiome modu…

This study tests a program to help Black women with breast cancer stick to their prescribed treatments, like chemotherapy or hormone therapy. Researchers will compare the program to standard care in 250 women recently diagnosed with early-stage breast cancer. The goal is to see i…

This study tests a drug called sacubitril-valsartan in young adult cancer survivors (diagnosed at or before age 39) who have early-stage heart failure (stage B) caused by past chemotherapy. The goal is to see if the drug is tolerable and can help control heart damage. About 53 pa…

This early-phase trial tests whether the drug olutasidenib can safely help people with a specific genetic form of acute myeloid leukemia (IDH1-mutant AML) stay in remission after standard chemotherapy. About 15 participants will take the drug twice daily. The main goals are to se…

This early-phase trial tests an oral drug called GZ17-6.02 in 30 men with castration-resistant prostate cancer that has progressed after standard hormone therapy. The goal is to see if the drug can delay cancer growth for at least 6 months. Participants take the drug twice daily …

This study tests whether adding the oral drug zanubrutinib to standard chemotherapy (R-CHOP) can improve outcomes for people with diffuse large B-cell lymphoma (DLBCL) who have certain genetic mutations (MYD88, CD79B, NOTCH1) or a specific marker (CD5+). About 21 adults will rece…

This pilot study tests whether adding a liquid nitrogen cryospray to standard treatments (balloon dilation or laser incision) can prevent benign airway stenosis from coming back within 6 months. About 12 adults with significant tracheal narrowing will receive the cryospray during…

This study tests whether giving radiation in 3 treatments over 1.5 days is safe and effective for women with early-stage breast cancer after lumpectomy. About 170 women aged 45-79 will participate. The goal is to see if this shorter course causes fewer side effects and maintains …

This study tests a non-surgical treatment for intermittent exotropia, a condition where one eye drifts outward. Children aged 4-7 will use a special headset for one hour daily, six days a week, for 12 weeks. The goal is to improve eye control and reduce the need for surgery.

This study tests whether a rotigotine skin patch (Neupro), already approved for Parkinson's disease, can help people with cocaine use disorder cut back on cocaine use when combined with behavioral therapy. Forty adults aged 25 to 70 with moderate to severe cocaine use disorder wi…

This study tests whether a urine test for a protein called CXCL10 can catch kidney transplant rejection that a standard blood test misses. Researchers will compare the urine test to biopsy results in 50 kidney transplant patients. They will also check if the urine samples can be …

This study will give thousands of elementary school students refillable water bottles and install hydration stations in their schools, along with lessons about healthy hydration. Researchers will track whether this simple change reduces tooth decay and helps maintain healthy body…

This study tests whether giving adults at risk for type 2 diabetes free fresh fruits and vegetables, along with a proven lifestyle program, can help them lower blood sugar and lose weight. One hundred adults with prediabetes will either get the standard diabetes prevention progra…

This study tests whether a program called Bridging the Gap, which combines in-hospital counseling with community support, can reduce retaliatory gun violence in adults treated for violent injuries. Researchers will enroll 616 adults who were hospitalized for a violence-related in…

This Phase 2 trial tests whether adding valbenazine (a daily pill) to standard botox injections can further reduce neck muscle spasms and pain in people with cervical dystonia. About 20 adults who still have symptoms despite botox will receive either valbenazine or a placebo for …

This study tests a computer program called C-SCAT that helps adolescents and young adults with cancer track and manage their symptoms. Participants use the tool to rate symptoms, find patterns, and plan how to cope. The goal is to see if using C-SCAT boosts their confidence and a…

This study tests whether community health workers can help caregivers of people with traumatic brain injury (TBI) during the move from rehab to home. About 126 adult caregivers will get either standard support or extra help from a health worker starting before discharge. The goal…

This study compares two 8-week virtual programs for adults with brain tumors who have thinking or memory issues. One program combines cognitive rehab with mindfulness (C-SMART), the other provides educational videos (BE Well). Researchers want to see if these programs are practic…

This study tests three different methods to protect the roof of the mouth after a gum graft. Fifty-six adults will rate their pain, swelling, and bleeding using a simple scale. The goal is to find which protection technique makes healing most comfortable.

This study is testing a mobile health app designed to help cancer survivors manage pain and other symptoms after treatment. Twenty-five survivors who have finished cancer treatment but still have pain will use the app for one week, receiving helpful messages and completing daily …

This study tests whether a 12-week home-based exercise program can improve heart and lung fitness in men with prostate cancer who are on hormone therapy (androgen deprivation therapy). Sixty men will either follow the exercise program or receive healthy living education. The goal…

This pilot study is testing whether breast cancer patients can apply azelaic acid cream twice daily during radiation treatment. The cream is meant to help with skin side effects from radiation. The study will enroll 33 adults with breast cancer who are about to start radiation th…

This study tests a low-cost training program for doctors and their patients with chronic pain. The program teaches team-based skills to manage pain and reduce reliance on opioids. About 1,188 participants (patients aged 14–80 and their doctors) will take part. The goal is to see …

This early-phase study tests whether anakinra, a drug that blocks inflammation, can make the heart more sensitive to inotropes (medicines that strengthen heart contractions) in people with end-stage heart failure. If successful, patients might need lower, safer doses of inotropes…

This study tests whether a 12-week program called Mindful Moms, which includes gentle yoga and mindfulness, can reduce depressive symptoms in pregnant women. About 200 pregnant women with mild to moderate depression will be randomly assigned to either Mindful Moms or standard pre…

This study tests whether special breathing exercises can help veterans and others with persistent post-concussion symptoms like headaches, dizziness, and memory trouble. The exercises aim to improve heart rate variability, a sign of how well the nervous system is working. 148 par…

This study is testing a new virtual therapy program called FearLess, designed to help people with primary malignant brain tumors and their caregivers cope with the intense fear that their cancer might come back. The program involves 8 weekly one-on-one video sessions with a thera…

This study tests a remote behavioral therapy called PAT-AN for adults recovering from anorexia. The therapy focuses on enhancing the brain's reward response to non-food experiences, like hobbies or socializing, to reduce reliance on weight-loss behaviors. Participants will receiv…

This study looks at how exercise training impacts blood vessel function in people with PTSD or generalized anxiety disorder, compared to healthy individuals. Researchers want to understand if harmful substances called oxidants play a role in blood vessel damage. The study involve…

This registry study is collecting blood and urine samples from 60 kidney transplant recipients who have BK virus infection. Researchers want to understand how the immune system responds to the virus and how immunosuppressive drugs affect that response. The goal is to find better …

This study looks at how long-term e-cigarette use impacts the health of tiny blood vessels (microvascular health) in young adults aged 18 to 29. Researchers will compare frequent e-cig users to non-users using non-invasive tests. The goal is to understand the body's response, not…

This study looks at whether it is safe and possible to do a special exercise test (MRI combined with a bike workout) in 20 people who already have a specific type of pacemaker. The goal is to see how different pacemaker settings affect the heart's pumping ability during light exe…

This study is following 700 adults with myotonic dystrophy type 1 (DM1) over two years. Researchers are measuring walking speed, lung function, and muscle tissue changes to find reliable markers of disease progression. The goal is to improve future clinical trials by better under…

This study is for children up to 4 years old with congenital myotonic dystrophy type 1 (CDM). Researchers want to find better ways to measure how the disease affects motor skills and language, and to identify biological markers. The goal is to improve future clinical trials and c…

This study tests a virtual reality program called SurviVRSE that teaches breast cancer survivors about heart health. Thirty women currently receiving certain cancer treatments will use the VR headset during one infusion session. Researchers will measure how much they learn, how e…

This study compares two methods for controlling a prosthetic arm: direct control (using signals from two muscles) and pattern recognition (using signals from several muscles to better understand the user's intended movement). Researchers want to see which method is easier to use …

This study tests an online version of a tablet-based assessment that asks children ages 3 to 7 to copy shapes, write letters, and cut paper. The goal is to see if the digital tool works as well as traditional pencil-and-paper tests, but is faster and more objective. Researchers w…

This study is testing whether a robotic ultrasound device can safely and effectively monitor blood flow in the brains of people with severe traumatic brain injury. The device is designed to work automatically for long periods, even in hospitals with little ultrasound experience. …

This study is testing whether a patient navigation program can increase the number of people who complete lung cancer screening. The study will enroll 675 Black or African-American adults who are at high risk for lung cancer due to smoking history. Participants will receive guida…

This study aims to understand how people with a lower limb amputation move around in their community, including both walking with a prosthetic and using a wheelchair or scooter. Researchers will give 50 participants a GPS tracker and an activity monitor to wear for 10-21 days to …

This study compares an AI-powered chatbot to traditional educational handouts for teaching African American adults about oral cancer. Researchers want to see which method helps people learn more about prevention, risk factors, and early signs. The goal is to find better ways to s…

This study looks at how the brains of young people with Postural Tachycardia Syndrome (POTS) process what they see. Researchers will use brain scans to compare brain activity in teens with POTS and healthy teens. The goal is to learn more about how different parts of the brain co…

This study follows 240 adults with NASH-related cirrhosis to find better ways to detect early signs of liver failure, such as internal bleeding, fluid buildup, or confusion. Researchers will track health records and exams over time to improve monitoring. The goal is to understand…

This study looks at how different exercise programs affect blood vessel function in people with PTSD or generalized anxiety disorder, compared to healthy individuals. Researchers will measure changes in arm and leg blood vessel dilation after 10 weeks of strength training. The go…

This study tests whether combining physical activity with a gentle brain stimulation technique (HD-tDCS) can lower anxiety more than either alone. Researchers will measure anxiety levels and brain blood flow in 29 healthy adults aged 18-50. The goal is to understand how these two…

This study looks at whether a new digital stethoscope can help parents of infants with fast heart rates (tachyarrhythmia) record clear heart readings at home. About 100 babies under 1 year old will take part. The goal is to see if parents can capture good-quality ECGs, which migh…

This study follows 50 adults with paroxysmal atrial fibrillation (AFib) who are scheduled for catheter ablation. Researchers will use exercise tests, heart MRIs, and echocardiograms to measure how well the heart's left atrium works during exercise before and 5-6 months after the …

This study tests whether a gentle, non-invasive brain stimulation can improve how people adapt their movements. Sixty healthy right-handed adults aged 18-40 will receive stimulation to specific brain areas while performing reaching tasks. The goal is to understand how the brain c…

This study looks at why people with Lewy body dementia have sudden changes in attention and thinking, called cognitive fluctuations. Researchers will use skin biopsies, brain scans, and EEG monitoring in 120 participants to link these symptoms to damage in a key brain chemical sy…

This study talks to transgender and gender-diverse youth aged 15-21 to learn what helps or stops them from taking part in research. The goal is to make research more welcoming and include their voices. No treatments or drugs are involved—just surveys and interviews.

This study looks at whether support programs in hospitals can reduce violence, gun use, and repeat injuries in teens aged 10-17 who were hurt in a violent incident. Researchers will track firearm-related incidents, beliefs, and deaths over time. The goal is to learn what works to…

This study looks at how different exercise programs affect blood vessel function in people with PTSD or generalized anxiety disorder. Researchers will compare moderate versus high intensity exercise in 360 participants. The goal is to see if exercise can improve vascular health, …

This 24-month observational study will follow up to 1000 people with certain types of muscular dystrophy (LGMD, DM2, and late-onset Pompe disease) aged 6-50. Researchers want to see if specific physical tests, like the North Star Assessment and a 100-meter walk, are good ways to …

This study looks at how the brain works in 120 adolescents with POTS, a condition causing rapid heart rate and dizziness when standing. Researchers will use brain scans and questionnaires to see if a problem in the brain's threat-detection system explains symptoms. The goal is to…

This study looks at how stress during childhood can impact heart and blood vessel health later on. Researchers will measure heart function, blood vessel flexibility, and lung function in 120 participants aged 9-30. The goal is to understand early signs of disease so that future p…