Virginia Commonwealth University

This phase 2 trial tests whether a once-weekly oral combination of decitabine-cedazuridine and venetoclax is safer and as effective as standard therapy for people with relapsed or refractory acute myeloid leukemia, high-risk myelodysplastic syndrome, or high-risk myeloproliferati…

This trial tests whether a gentle electrical earpiece, worn twice daily for two weeks, can reduce brain swelling caused by radiation necrosis. The device stimulates a nerve in the ear to calm inflammation. Forty people with brain tumors who need a laser procedure will be randomly…

The SASHA trial is testing whether a single, high-dose radiation treatment delivered directly to the tumor site over one day is safe and effective for women with early-stage breast cancer. The study will enroll 134 women aged 40-85 who have already had a lumpectomy. Researchers w…

This phase 2 trial tests a drug called sacituzumab tirumotecan in people with neuroendocrine prostate cancer, a rare and aggressive form that has progressed after platinum-based chemotherapy. The drug is given by IV infusion three times per 42-day cycle. The study measures how ma…

This study tests a telehealth program called Virtual Housecalls for teens aged 12-15 with class I obesity. The program provides 26 hours of lifestyle coaching via video calls. Researchers want to see if it helps teens maintain a healthier weight compared to standard care. The tri…

This pilot study tests whether adding the immunotherapy drugs cemiplimab (with or without fianlimab) after a standard liver cancer procedure called Y90 radioembolization can help control hepatocellular carcinoma. About 20 adults with liver cancer will be randomly assigned to one …

This study aims to improve an existing violence prevention program for high-risk youth by adding content that directly addresses firearm safety. Researchers will work with about 45 teens aged 13-17 to develop and test new materials. The goal is to reduce the risk of intentional f…

This study tests whether regular breathing exercises can improve symptoms of Postural Tachycardia Syndrome (POTS), a condition that causes dizziness and rapid heartbeat when standing. Twelve adults with POTS will practice breathing exercises daily for four weeks while researchers…

This study will test whether a wearable device called Apollo Neuro is practical and acceptable for autistic children aged 6 to 14 who hurt themselves. The device delivers low-intensity vibrations through the skin. For about a month, 18 children will wear it at least 3 hours a day…

This study is a registry that will collect health information from 1,000 people who carry the gene for hereditary amyloidosis, including those with and without symptoms. Researchers will track who develops the disease and how it progresses, including the need for heart transplant…

This early-stage trial will test whether an experimental drug called VVZ-2471 is safe and tolerable in 60 healthy adults aged 18 to 65 who show high impulsivity. Participants will take either the drug or a placebo twice daily for 14 days. The results will help researchers design …

This study will use transcranial Doppler (TCD) ultrasound to measure blood flow in the brains of 100 people who had a stroke and underwent endovascular therapy (clot removal). The goal is to see if TCD readings can predict complications like bleeding or brain swelling in the days…

This study explores whether a younger adult (ages 25-44) can encourage an older family member (ages 45-75) in rural areas to get screened for colorectal cancer. Researchers will first survey 300 people, then run focus groups, and finally test the approach with 15 parent-child pai…