Could a single day of radiation replace weeks of treatment for breast cancer?

NCT ID NCT07654257

Not yet recruiting Disease control Sponsor: Virginia Commonwealth University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

The SASHA trial is testing whether a single, high-dose radiation treatment delivered directly to the tumor site over one day is safe and effective for women with early-stage breast cancer. The study will enroll 134 women aged 40-85 who have already had a lumpectomy. Researchers will monitor side effects and cosmetic results for up to five years.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: radiation therapy (brachytherapy)
What this could lead to: If successful, this could offer a faster, more convenient radiation option for early-stage breast cancer with fewer side effects.
What could go wrong: This is a phase 2 trial with only 134 participants, so results are preliminary. The single high dose may cause unexpected side effects or not be as effective as standard longer courses.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

breast cancer breast neoplasm ductal breast carcinoma in situ invasive breast carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BREAST CANCER

Contacts and locations

Locations

Virginia Commonwealth University

Richmond, Virginia, 23298, United States

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