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Parkinson's drug patch could curb cocaine cravings

NCT ID NCT05886582

Recruiting now Disease control Sponsor: Virginia Commonwealth University Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Aug 11, 2026 · Updated 3 times

Summary

This study tests whether a rotigotine skin patch (Neupro), already approved for Parkinson's disease, can help people with cocaine use disorder cut back on cocaine use when combined with behavioral therapy. Forty adults aged 25 to 70 with moderate to severe cocaine use disorder will receive either the patch or a placebo for six weeks. Researchers will measure cocaine use via urine tests and self-reports, and also check for improvements in brain activity and thinking skills.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Rotigotine (Neupro) transdermal patch
What this could lead to
If it works, this could point toward a new medication to help people with cocaine use disorder reduce their cocaine use and improve cognitive control.
What could go wrong
This is a small, early-phase trial with only 40 participants, so results may not apply widely. The drug is not yet proven for this condition and may cause side effects like skin reactions or nausea.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cocaine dependence substance-related disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SUBSTANCE-RELATED DISORDERS

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

  • Contact

    Email: •••••@•••••

Locations

  • Virginia Commonwealth University

    RECRUITING

    Richmond, Virginia, 23284, United States

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