Scientists map brain circuits with TMS to personalize mental health treatment

NCT ID NCT06376734

Recruiting now Knowledge-focused Sponsor: Brigham and Women's Hospital Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jul 17, 2026 · Updated 3 times

Summary

This study uses transcranial magnetic stimulation (TMS) to map brain circuits in 180 adults with depression, OCD, anxiety, or schizophrenia. Participants receive accelerated TMS over two days while completing behavioral tests and questionnaires. The goal is to understand which brain circuits control which behaviors, not to treat symptoms directly.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Transcranial magnetic stimulation (TMS)
What this could lead to: If successful, this could help personalize TMS therapy by targeting specific brain circuits for different mental health conditions.
What could go wrong: This is an early-phase mapping study, not a treatment trial. It may not lead to direct clinical benefits, and results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

anxiety disorder Depression generalized anxiety disorder major depressive disorder mental disorder mood disorder obsessive-compulsive disorder psychiatric disorder schizophrenia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DEPRESSION, ANXIETY GENERALIZED ANXIETY DISORDER MAJOR DEPRESSIVE DISORDER MENTAL DISORDER MOOD DISORDERS OBSESSIVE-COMPULSIVE DISORDER PSYCHIATRIC DISORDER SCHIZOPHRENIA

Contacts and locations

Locations

Acacia Clinics
RECRUITING

Sunnyvale, California, 94087, United States
Brigham and Women's Hospital
ACTIVE_NOT_RECRUITING

Boston, Massachusetts, 02115, United States

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