MOOD DISORDERS

This study is testing a new coordinated care program called I-CONNECT for older adults who have depression or bipolar disorder along with at least two chronic physical conditions like diabetes or high blood pressure. Researchers want to see if this program, which provides a perso…

This study tests whether giving multiple brain stimulation treatments per day works better than one daily treatment for depression in people aged 60+. All participants receive active treatment, but some get multiple sessions daily for a shorter period while others get one session…

This study is testing whether a new, fast-acting drug called (2R,6R)-HNK can help people with major depression who haven't gotten better with standard treatments. Fifty participants will receive intravenous infusions of either the study drug or a placebo over several weeks to see…

This large study is testing whether using a person's genetic information can help doctors prescribe psychiatric medications more effectively. It will compare standard prescribing against a method that uses genetic test results to guide drug choice and dosage. The goal is to see i…

This study is testing whether a single session combining a non-invasive brain stimulation technique (rTMS) with training in emotion regulation skills can help people who struggle to calm down when upset. Researchers want to see if this combined approach changes brain activity and…

This study is testing whether a single session of whole-body heat therapy, with or without a follow-up cold water plunge, can help reduce symptoms of depression. It will involve about 112 adults currently experiencing depression, who will be randomly assigned to one of the two tr…

This study is testing a smartphone app designed to help people recover from knee or hip replacement surgery. The app uses digital therapy techniques and coach support to help patients manage anxiety, depression, and pain. Researchers want to see if using the app can help patients…

This study is testing a brief therapy called Imagery Rescripting to help reduce symptoms of depression. It will be offered by mental health assistants in a primary care doctor's office. The therapy involves working with patients to rewrite negative memories linked to their low mo…

This study aims to understand how stimulating different parts of the brain with magnetic pulses affects symptoms of several mental health conditions. Researchers will enroll 180 adults with depression, anxiety, OCD, or schizophrenia to receive non-invasive brain stimulation at ra…

This study is not a treatment trial. Its main purpose is to screen a large number of people—including those with mood or anxiety disorders and healthy volunteers—to understand these conditions better and to find suitable participants for future research studies. Participants unde…

This study is creating a large, standardized research platform to help scientists understand mood disorders like depression and bipolar disorder better. It will collect detailed information, including brain scans and blood samples, from 900 participants to look for biological clu…

This study aims to develop better brain scanning techniques to understand mood and anxiety disorders like depression. Researchers will use MRI scans and thinking tests to compare brain structure and activity in 300 healthy volunteers and 90 people with major depression. The goal …

This study is testing whether a virtual reality device can detect changes in eye movements in people who have been taking psychiatric medications for at least three months. Researchers want to see if the device can identify patterns linked to medication use, similar to how police…