MOOD DISORDERS

This study tests whether using a person's genetic information to choose psychiatric medications leads to better recovery than standard prescribing. About 2,500 adults with depression, anxiety, or psychotic disorders will receive either genetically tailored treatment or usual care…

This study is testing a new coordinated care program called I-CONNECT for people aged 65 and older who have depression or bipolar disorder along with at least two other long-term health conditions like diabetes or high blood pressure. Researchers want to see if having a care coor…

This study tests a program called Resilience Training for college students who have mild psychotic experiences, like unusual thoughts or perceptions. The goal is to see if this training can prevent them from developing a serious mental illness. About 192 students aged 18-30 will …

This study looks at whether cognitive-behavioral therapy, exercise training, or both can lower the risk of type 2 diabetes in teenage girls. Participants are 300 girls aged 12-17 who are at higher risk due to family history, weight, and mood symptoms. The goal is to see if these …

This study tests whether giving multiple brain stimulation sessions per day works better than one session per day for treating depression in people aged 60 and older. About 280 participants will receive active treatment, but some get the accelerated version and some get the stand…

This study tests whether a telemedicine-delivered cognitive behavioral program (RxWell) can help patients use fewer opioid painkillers after knee or hip replacement. About 150 adults with mild to moderate anxiety or depression symptoms will be enrolled. The program aims to improv…

This study tests a new drug called (2R,6R)-HNK to see if it can quickly improve symptoms in people with major depression that hasn't responded to other treatments. About 50 adults aged 18 to 70 will receive four infusions of HNK and four of a placebo over several weeks, with thei…

This study explores whether a technique called imagery rescripting (ImRs) can help reduce depression when delivered by mental health assistants in primary care. 12 adults with depressive symptoms will receive 5 sessions over 10 weeks, where they work to change negative memories l…

This study is testing whether a single session of whole-body heating, with or without a cold water plunge, can reduce symptoms of depression. Researchers will recruit 162 adults aged 18-65 who currently have depressive symptoms. Participants will be randomly assigned to receive e…

This study is testing whether a self-guided online course that teaches dialectical behavior therapy (DBT) skills is practical and helpful for adults with mild-to-moderate depression and anxiety. About 40 participants will take the 8-week course and complete surveys to measure how…

This study aims to understand how different parts of the brain's prefrontal cortex control behaviors in people with major depression, obsessive-compulsive disorder, generalized anxiety disorder, or schizophrenia. Participants will receive transcranial magnetic stimulation (TMS) a…

This study aims to improve MRI scanning methods to better understand how mood and anxiety disorders affect the brain. Researchers will compare brain structure and activity in healthy volunteers and people with major depressive disorder while they perform tasks. The goal is to dev…

This study looks at 300 people with mood disorders to find out what makes someone more likely to think about or attempt suicide. Researchers will use questionnaires and collect blood and urine samples to look for biological and psychological clues. The goal is to create a list of…

This study looks at whether a special eye-tracking device can spot changes in eye movements caused by long-term use of psychiatric medications like those for ADHD, depression, or anxiety. Researchers will test 50 adults who have been on these medications for over three months. Th…

This study tests whether a single session of brain stimulation (rTMS) combined with emotion regulation skills training can help people with mood, anxiety, or related disorders better control their emotions. 240 adults aged 18-55 with high emotional distress will be randomly assig…

This study screens up to 16,000 people aged 3 to 99 with mood or anxiety disorders, as well as healthy volunteers, to see if they can join other research studies at the National Institute of Mental Health. Participants undergo interviews, medical tests, and brain scans to collect…

This study is creating a large, standardized research platform to help scientists understand mood disorders like depression and bipolar disorder better. It will enroll 900 people, including those with mood disorders and healthy volunteers, to collect detailed clinical information…