MOOD DISORDERS

This pilot study explores whether real-time fMRI neurofeedback can help veterans reduce suicide-specific rumination—the repetitive mental fixation on suicidal thoughts. Sixteen veterans will receive two brain-training sessions, learning to modulate activity in brain regions linke…

This early-phase trial tests a new brain stimulation target for people with depression plus at least one other psychiatric disorder, such as anxiety, OCD, or PTSD. The treatment uses a non-invasive form of brain stimulation called accelerated intermittent theta burst stimulation …

This study tests whether using brain scans to guide transcranial magnetic stimulation (TMS) works better than standard head measurements for treating depression. Participants with major depressive disorder receive accelerated TMS, but they won't know if their treatment spot was c…

This study tested a behavioral therapy called BE-SMART-DR in 65 teens and young adults with bipolar disorder or major depression who had suicidal thoughts or past attempts. The therapy teaches self-directed strategies to regularize sleep and other daily rhythms to reduce short-te…

This study tested two natural supplement combinations—omega-3 plus inositol versus N-acetylcysteine (NAC)—to see if they could help children and teens (ages 5-17) with emotional ups and downs. Over 6 weeks, 27 participants took one of the two treatments. The goal was to find a ge…

This study tested a program called Mood Lifters for college students. 125 undergraduates attended 14 weekly virtual meetings to learn mental health strategies. The goal was to see if this low-cost, peer-led approach could reduce symptoms of depression, anxiety, and stress. Resear…

This study tested whether a drug called esketamine works as well as electroconvulsive therapy (ECT) for quickly reducing suicidal thoughts in people with depression. 340 adults with major depression or bipolar disorder and active suicidal ideas took part. They received either esk…

This study looked at nearly 2,000 people from the community to understand how depression, anxiety, and migraine are passed down through families. Researchers interviewed family members of all ages, including children as young as 8, to track patterns of these conditions over time.…

This study tested whether a smartphone app that tracks how you type (speed, backspace use, autocorrect) can help monitor mood and thinking problems in people with mood disorders like depression or bipolar disorder. 132 adults aged 25-50 took part. The goal was to see if this simp…

This completed study from the University of Toronto looked at whether certain gut bacteria are linked to anxiety, depression, and panic disorders. 500 adults provided stool samples to test for H. pylori and other bacteria. The goal was to understand possible root causes, not to t…

This study looked at whether giving 7-11-year-old children in Shanghai a daily breakfast with fruits and vegetables could improve their thinking, mood, and attention. Over 250 kids took part, receiving a balanced breakfast every day for 12 weeks. Researchers measured changes in c…

This study tested whether a brain wave measurement called mismatch negativity (MMN) can help match veterans with mental illness to the most effective cognitive training program. 100 veterans with conditions like schizophrenia, PTSD, or mood disorders participated. The goal was to…

This study tested whether a virtual therapy platform called Teleo helps children stay more engaged in online psychotherapy compared to standard video calls. Researchers enrolled 41 children with anxiety or mood disorders and measured engagement through video coding and caregiver …