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Brain scans could make TMS for depression more precise

NCT ID NCT05680727

Completed Symptom relief Sponsor: Brigham and Women's Hospital Source: ClinicalTrials.gov ↗

First seen Jul 07, 2026 · Last updated Jul 08, 2026 · Updated 1 time

Summary

This study tests whether using brain scans to guide transcranial magnetic stimulation (TMS) works better than standard head measurements for treating depression. Participants with major depressive disorder receive accelerated TMS, but they won't know if their treatment spot was chosen by neuroimaging or by traditional methods. The goal is to see if personalized targeting improves depression scores one month after treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
transcranial magnetic stimulation (TMS)
What this could lead to
If successful, this could show that personalized brain imaging improves TMS outcomes for depression, leading to more effective treatments.
What could go wrong
This is a small Phase 2 trial, so results may not apply to everyone. The benefit of imaging-guided targeting may be small or absent, and TMS can cause headache or scalp discomfort.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Depression depressive disorder major depressive disorder mental disorder mood disorder psychiatric disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DEPRESSION DEPRESSIVE DISORDER, MAJOR MENTAL DISORDER MOOD DISORDERS PSYCHIATRIC DISORDER

Contacts and locations

Locations

  • Brigham and Women's Hospital

    Boston, Massachusetts, 02115, United States

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