DEPRESSIVE DISORDER, MAJOR

This study is testing whether using a person's own brain scan to guide magnetic stimulation treatment works better than the standard approach for major depression. Researchers will enroll 210 adults with depression who haven't responded well to medication. Participants will recei…

This study is testing whether adding a new drug called seltorexant to standard antidepressants helps adults and elderly patients who have major depression along with insomnia. The goal is to see if it improves depression symptoms and sleep better than a placebo, and if the benefi…

This small pilot study is testing whether a faster schedule of a non-invasive brain stimulation treatment works better for teenagers with depression that hasn't improved with medication. Researchers are comparing a new, accelerated schedule (three treatments per day for two weeks…

This study is testing if adding the anti-inflammatory drug celecoxib to standard depression treatment works better than a placebo for a specific group of patients. It focuses on people with 'Immuno-Metabolic Depression,' a type linked to inflammation, weight gain, and extreme fat…

This study aims to develop a smartphone app to help treat depression. Researchers want to see if suggesting small, personalized daily activities (like taking a short walk) can boost people's energy and improve their mood. They are recruiting 180 adults with depression to test how…

This study is testing whether an experimental drug called JNJ-89495120 can reduce depression symptoms better than a placebo. Researchers will enroll 124 adults with major depressive disorder and measure changes in their symptoms over just 5 days. The trial is designed to see if t…

This study is testing a new method to deliver brain stimulation therapy for depression in people with spinal cord injuries. Many people with these injuries can't use the standard treatment because it requires hand movement to set the dose. Researchers are testing a computer model…

This study is testing whether a new, fast-acting drug called (2R,6R)-HNK can help people with major depression who haven't gotten better with standard treatments. Fifty participants will receive intravenous infusions of either the study drug or a placebo over several weeks to see…

This study is testing whether a new brain training software called Prism can help people with major depression, especially those who have lost pleasure in activities. Participants will use the Prism device during 20 clinic sessions over 10 weeks while researchers measure their br…

This study is testing whether a nasal spray called esketamine, when added to standard mental health care, can quickly reduce severe depression and suicidal thoughts in teenagers. It will compare the spray to a placebo (a look-alike treatment with no active drug) in about 258 teen…

This study is testing a new social skills training program designed to help Veterans with serious mental health conditions. The program teaches skills for understanding social cues and navigating work relationships, aiming to improve job success and quality of life. Researchers a…

This study aims to understand how a specific brain circuit involved in making decisions (like approaching rewards or avoiding threats) works differently in people with depression or anxiety. Researchers will give an experimental drug to 112 unmedicated participants and use MRI br…

This study aims to better understand sleep in people with major depression, particularly those who also have insomnia. Researchers will use a comfortable headband that records brain activity during sleep at home, and compare it with participants' own reports about their sleep qua…

This study aims to understand why electroconvulsive therapy (ECT) works for some people with severe depression but not others. Researchers will scan the brains and test blood and spinal fluid of 30 patients before and after ECT treatment to look for patterns. The goal is to find …

This study aims to find brain-based markers that could help predict how well someone with major depression will respond to a specific treatment called transcranial magnetic stimulation (TMS). Researchers will use brain scans and EEG recordings on 50 participants before, during, a…