DEPRESSIVE DISORDER, MAJOR

This study tests whether a nasal spray containing esketamine, given alongside standard care, can quickly reduce symptoms of major depression and suicidal thoughts in teenagers. About 258 adolescents with acute suicidal thoughts will receive either the active spray or a placebo th…

This study tests whether using a personalized brain scan to guide a non-invasive treatment called iTBS works better than the standard one-size-fits-all approach for people with major depression. 210 adults will receive 6 weeks of iTBS, with half getting the standard target and ha…

This study tests a new treatment called Prism for people with major depression who have lost interest or pleasure in activities (anhedonia). Prism is a software device that uses neurofeedback to train the brain's reward system. About 170 adults will be randomly assigned to receiv…

This study tests whether adding roflumilast, a drug used for other conditions, to standard antidepressants can better reduce depression symptoms. About 60 adults with major depression and high symptom scores will take the combination for 8 weeks. The main goal is to see if depres…

This study tests a new drug called seltorexant in adults and elderly people with major depression, especially those who also have trouble sleeping. About 600 participants will receive either the drug or a placebo to see if it reduces depressive symptoms. The study also checks lon…

This study tests a new drug called (2R,6R)-HNK to see if it can quickly improve symptoms in people with major depression that hasn't responded to other treatments. About 50 adults aged 18 to 70 will receive four infusions of HNK and four of a placebo over several weeks, with thei…

This study tests a new drug, mitizodone phosphate, to see if it can safely reduce symptoms of major depression. About 600 adults with moderate to severe depression will receive either the drug or a placebo for 8 weeks. The goal is to find the best dose and confirm whether the dru…

This study tests whether giving brain stimulation three times a day works better than once a day for teens with depression that hasn't improved with medication. Ten adolescents aged 16-19 will receive either accelerated or standard fMRI-guided theta burst stimulation. The goal is…

This study tests a drug called seltorexant for people with major depression who also have trouble sleeping and haven't gotten enough help from their current antidepressant. About 752 adults and elderly will take either seltorexant or a placebo pill alongside their usual antidepre…

This study tests a new method to dose repetitive transcranial magnetic stimulation (rTMS) for treating depression in people with spinal cord injury (SCI). Standard rTMS dosing relies on thumb movement, which many with SCI cannot do. The study will enroll 24 Veterans with SCI and …

This study tests whether using a bright light box at home for 40 minutes each morning can help teens aged 13-17 with major depression feel better. Participants are split into three groups: high-intensity light, medium-intensity light, or a dim red placebo light. The trial lasts 4…

This study tests an experimental drug called JNJ-89495120 to see if it can quickly reduce depression symptoms in adults with major depressive disorder. About 124 participants will receive either the drug or a placebo, and researchers will measure mood changes using a standard dep…

This study tests an experimental drug to see if it can change how the brain processes decisions involving reward or risk in people with major depression or anxiety disorders. Participants will undergo brain scans and complete behavioral tasks while taking the drug or a placebo. T…

This study aims to understand sleep patterns in people with major depressive disorder who have either moderate-to-severe insomnia or mild-to-no insomnia. About 80 participants will wear a headband at home that records brain activity during sleep, and also fill out sleep diaries a…

This study is testing a new social skills training program designed to help veterans with serious mental illness (like schizophrenia, bipolar disorder, or PTSD) improve their work relationships and job success. About 20 veterans will take part in weekly group sessions and practic…

This study aims to find biological signs in the brain that can help doctors diagnose major depression and predict how well a person will respond to treatment. Researchers will use brain imaging and EEG to track changes in 50 adults with depression as they undergo transcranial mag…

This study looks at how ketamine helps people with hard-to-treat depression and PTSD. Researchers will give a drug called perampanel along with ketamine to see how it changes brain activity. About 50 adults with depression or PTSD will join. The goal is to learn more about how ke…

This study tests a virtual reality (VR) tool called bWell to see if it can help assess and improve thinking skills in people with major depression. About 40 adults aged 19-55 with mild depression and self-reported memory or focus issues will try the VR assessments and either cogn…

This study looks at whether increasing dopamine can help with motivation and movement problems in people with major depression who have signs of inflammation. Researchers will give a dopamine-boosting drug or a placebo to 165 participants (depressed patients and healthy volunteer…

This study looks at how everyday physical activities, like walking to the store or doing chores, affect energy levels and mood in people with depression. Researchers will use activity trackers and electronic diaries to collect real-time data from 180 participants. The goal is to …

This study looks at how electroconvulsive therapy (ECT) changes the brain in people with severe depression. Researchers will use MRI scans and lab tests before and after ECT to find clues that predict who will get better. The goal is to make ECT more personalized and effective fo…

This study looks at how nitrous oxide (laughing gas) changes brain connections in people with treatment-resistant depression compared to healthy volunteers. About 60 adults will have brain scans before and after breathing nitrous oxide or a placebo. The goal is to understand whic…