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New shot aims to keep depression away longer

NCT ID NCT07412756

Disease control Sponsor: Eli Lilly and Company Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Aug 07, 2026 · Updated 6 times

Summary

This study tests whether adding a new drug called brenipatide to standard depression treatment can delay the return of major depressive symptoms. About 1000 adults with major depression who are already on stable medication will receive either brenipatide or a placebo as a shot, plus their usual care, for at least 12 months. The goal is to see if brenipatide helps people stay well longer.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

About 1,000 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2026

Expected to finish

Feb 2028

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Meet the diagnostic criteria for major depressive disorder * Are on a stable standard of care medication for major depressive disorder * Are reliable and willing to make themselves available for the duration of the study and attend required study visits, and are willing and able to follow study procedures as required, such as * self-inject study intervention * store and use the provided blinded study intervention, as directed * maintain electronic and paper study diaries, as applicable, and * complete the required questionnaires Exclusion Criteria: * Have a lifetime history or current diagnosis of the following: * schizophrenia or other psychotic disorder * bipolar disorder * borderline personality disorder, or * any eating disorder. * Have type 1 diabetes mellitus, or a history of * ketoacidosis, or * hyperosmolar state or coma. * Evidence of moderate or severe substance or alcohol use disorder within 180 days of screening * Are actively suicidal or deemed a significant risk for suicide * Have participated in a clinical study and received active treatment, or unknown if they received active treatment, within 90 days or 5 half-lives (whichever is longer) before screening

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Conditions

The condition(s) this trial relates to.

Depression depressive disorder major depressive disorder mood disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Depressive disorder, major

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    179 sites in 15 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • 3rd People's Hospital of Huzhou

    RECRUITING

    Huzhou, 313000, China

  • A2Z Clinical Centro Avançado De Pesquisa Clínica - Valinhos

    RECRUITING

    Valinhos, 13271-130, Brazil

  • ALPHA Recherche Clinique

    RECRUITING

    Québec, G3K 2P8, Canada

  • ATP Clinical Research

    RECRUITING

    Orange, California, 92866, United States

  • Abe Clinic - Arakawa

    RECRUITING

    Arakawa City, 116-0014, Japan

  • Accellacare - Moorpark

    RECRUITING

    Moorpark, California, 93021, United States

  • Adams Clinical Boston

    RECRUITING

    Boston, Massachusetts, 02116, United States

  • Adams Clinical Dallas

    RECRUITING

    DeSoto, Texas, 75115, United States

  • Adams Clinical Harlem

    RECRUITING

    New York, New York, 10029, United States

  • Adams Clinical Watertown

    RECRUITING

    Watertown, Massachusetts, 02472, United States

  • Aiginiteio University Hospital

    NOT_YET_RECRUITING

    Athens, 115 28, Greece

  • Alpha Recherche Clinique

    RECRUITING

    Québec, G2J 0C4, Canada

  • Alpha Recherche Clinique - Lévis

    RECRUITING

    Lévis, G6V 0C9, Canada

  • Alpine Research Organization

    RECRUITING

    Clinton, Utah, 84015, United States

  • Arata Clinic

    RECRUITING

    Nagasaki, 852-8137, Japan

  • Arch Clinical Trials

    RECRUITING

    St Louis, Missouri, 63141, United States

  • Arcturus Healthcare , PLC, Troy Internal Medicine Research Division

    RECRUITING

    Troy, Michigan, 48098, United States

  • Argolida General Hospital

    RECRUITING

    Argos, 212 00, Greece

  • Arké SMO S.A de C.V

    NOT_YET_RECRUITING

    Veracruz, 91900, Mexico

  • Asan Medical Center

    RECRUITING

    Seoul, 05505, South Korea

  • Atlantic Medical

    RECRUITING

    Penzance, TR18 3DX, United Kingdom

  • Attikon General University Hospital

    RECRUITING

    Chaïdári, 124 62, Greece

  • B&B Investigaciones Medicas S.C.

    NOT_YET_RECRUITING

    Mazatlán, 82103, Mexico

  • BR Trials - Ensaios Clinicos e Consultoria

    RECRUITING

    São Paulo, 01236030, Brazil

  • Barwon Health

    RECRUITING

    Geelong, 3220, Australia

  • Beijing Anding Hospital - Affiliated Capital University of Medical Science

    RECRUITING

    Beijing, 100088, China

  • Beijing HuiLongGuan Hospital

    RECRUITING

    Beijing, 100096, China

  • Bluewater Clinical Research Group Inc.

    NOT_YET_RECRUITING

    Sarnia, N7T 4X3, Canada

  • CLA Research

    RECRUITING

    Naples, Florida, 34116, United States

  • CPCLIN

    NOT_YET_RECRUITING

    São Paulo, 01228-200, Brazil

  • CPQuali Pesquisa Clínica

    RECRUITING

    São Paulo, 01228-000, Brazil

  • Cedar Valley Medical Specialists

    RECRUITING

    Waterloo, Iowa, 50701, United States

  • CenExel iResearch, LLC

    RECRUITING

    Decatur, Georgia, 30030, United States

  • Centre de Recherche Saint-Louis inc.

    NOT_YET_RECRUITING

    Québec, G1W 4R4, Canada

  • Centre for Neurology Studies

    NOT_YET_RECRUITING

    Surrey, V3V 0E8, Canada

  • Centro de Atención Integral La Corredoria

    NOT_YET_RECRUITING

    Oviedo, 33011, Spain

  • Centro de Investigacion Clinica Chapultepec

    NOT_YET_RECRUITING

    Morelia, 58260, Mexico

  • Centro de Pesquisa Clínica de Marília - CPCLIM

    RECRUITING

    Marília, 17504-072, Brazil

  • Centrum Badan Klinicznych PI-House sp. z o.o.

    NOT_YET_RECRUITING

    Gdansk, 80-546, Poland

  • Centrum Medyczne Euromedis

    NOT_YET_RECRUITING

    Szczecin, 70-111, Poland

  • Centrum Medyczne Ginemedica

    NOT_YET_RECRUITING

    Wroclaw, 50-414, Poland

  • Chang Gung Medical Foundation-Linkou Branch

    RECRUITING

    Taoyuan, 333, Taiwan

  • Charter Research - Orlando

    RECRUITING

    Orlando, Florida, 32803, United States

  • Cheng Hsin General Hospital

    NOT_YET_RECRUITING

    Taipei, 112, Taiwan

  • Chonnam National University Hospital

    RECRUITING

    Gwangju, 61469, South Korea

  • Chung Shan Medical University Hospital

    RECRUITING

    Taichung, 402, Taiwan

  • Circle Clinical Research

    NOT_YET_RECRUITING

    Sioux Falls, South Dakota, 57104, United States

  • Clerkenwell Health - London - Welbeck Street

    RECRUITING

    London, W1G 8DR, United Kingdom

  • Clinhouse Centrum Medyczne

    NOT_YET_RECRUITING

    Zabrze, 41-807, Poland

  • Clinica de Investigacion en Reumatologia y Obesidad S. C.

    NOT_YET_RECRUITING

    Guadalajara, 44650, Mexico

  • Clinilive

    RECRUITING

    Maringá, 87013-250, Brazil

  • Complejo Asistencial de Zamora

    RECRUITING

    Zamora, 49021, Spain

  • Consano Clinical Research, LLC

    RECRUITING

    Shavano Park, Texas, 78231, United States

  • Dar Clinical Research - Ottawa

    RECRUITING

    Ottawa, K2J 3Z6, Canada

  • Devon Partnership Trust

    RECRUITING

    Exeter, EX2 5AF, United Kingdom

  • Diamond Clinic

    NOT_YET_RECRUITING

    Krakow, 31-559, Poland

  • Diex Recherche Sherbrooke

    SUSPENDED

    Sherbrooke, J1L 0H8, Canada

  • Edinburgh Royal Infirmary

    NOT_YET_RECRUITING

    Edinburgh, EH16 4SA, United Kingdom

  • Encore Medical Research

    RECRUITING

    Hollywood, Florida, 33024, United States

  • Facili Centro Integrado de Psiquiatria

    RECRUITING

    São Bernardo do Campo, 09726-150, Brazil

  • Floridian Clinical Research, LLC

    RECRUITING

    Miami Lakes, Florida, 33016-1518, United States

  • Fujimidai Hospital

    RECRUITING

    Hiratsuka, 259-1205, Japan

  • Fukuoka University Hospital

    RECRUITING

    Fukuoka, 814-0180, Japan

  • FutureMeds GmbH

    RECRUITING

    Berlin, 10629, Germany

  • GabiPros

    NOT_YET_RECRUITING

    Mexico City, 07000, Mexico

  • General Hospital of Tripoli Panarkadiko Evangelistria

    RECRUITING

    Tripoli, 221 00, Greece

  • Genge Partners

    NOT_YET_RECRUITING

    Montreal, H4A 3T2, Canada

  • Guangzhou Brain Hospital

    RECRUITING

    Guangzhou, 510370, China

  • Hefei No.4 People's Hospital

    RECRUITING

    Hefei, 230061, China

  • Heritage Medical Research Clinic

    NOT_YET_RECRUITING

    Calgary, T2N 4Z6, Canada

  • Himorogi Psychiatric Institute - Tokyo - Ichigayatamachi

    RECRUITING

    Tokyo, 162-0843, Japan

  • Hirota Clinic

    RECRUITING

    Kurume, 830-0033, Japan

  • Horikoshi Mental Somatic Clinic

    RECRUITING

    Fukushima, 960-8053, Japan

  • Hospital Clínic de Barcelona

    RECRUITING

    Barcelona, 08036, Spain

  • Hospital Universitari Vall d'Hebron

    RECRUITING

    Barcelona, 08035, Spain

  • Hospital Universitario Infanta Leonor

    RECRUITING

    Madrid, 28031, Spain

  • Hospital Universitario de Salamanca - Complejo Asistencial Universitario de Salamanca

    RECRUITING

    Salamanca, 37005, Spain

  • Hospital Universitário Onofre Lopes

    RECRUITING

    Natal, 59012-300, Brazil

  • Hospital das Clínicas da UFMG

    NOT_YET_RECRUITING

    Belo Horizonte, 30130-100, Brazil

  • Hospital de la Santa Creu i Sant Pau

    RECRUITING

    Barcelona, 08041, Spain

  • ISPG - Institut für Studien zur Psychischen Gesundheit

    RECRUITING

    Mannheim, 68165, Germany

  • Indiana University Health Neuroscience Center

    RECRUITING

    Indianapolis, Indiana, 46202, United States

  • Institucion Hosp Hestia Palau

    NOT_YET_RECRUITING

    Barcelona, 08025, Spain

  • Jeju National University Hospital

    RECRUITING

    Jeju City, 63241, South Korea

  • Jimbocho Mental Clinic

    RECRUITING

    Chiyoda City, 101-0051, Japan

  • K2 Medical Research - Foxborough

    RECRUITING

    Foxborough, Massachusetts, 02035, United States

  • K2 Medical Research - Maitland

    RECRUITING

    Maitland, Florida, 32751, United States

  • K2 Medical Research - Tampa

    RECRUITING

    Tampa, Florida, 33634, United States

  • Keelung Chang Gung Memorial Hospital

    RECRUITING

    Keelung, 204, Taiwan

  • Kelowna Health and Memory Centre

    NOT_YET_RECRUITING

    Kelowna, V1Y 5A8, Canada

  • Ketamine Clinic México

    NOT_YET_RECRUITING

    Mexico City, 04100, Mexico

  • Kishiro Mental Clinic

    RECRUITING

    Kawasaki, 214-0014, Japan

  • Kokorono Clinic Hirao

    RECRUITING

    Fukuoka, 815-0071, Japan

  • Konkuk University Medical Center

    RECRUITING

    Seoul, 05030, South Korea

  • Korea University Ansan Hospital

    RECRUITING

    Ansan-si, 15355, South Korea

  • Kure Medical Center

    RECRUITING

    Kure, 737-0023, Japan

  • Life Medical Research Group Corp

    RECRUITING

    Miami Gardens, Florida, 33014, United States

  • Lyell McEwin Hospital

    NOT_YET_RECRUITING

    Elizabeth Vale, 5112, Australia

  • Maple Leaf Research

    SUSPENDED

    Toronto, M5G 1K2, Canada

  • Maynds Tower Mental Clinic

    RECRUITING

    Shibuya-ku, 151-0053, Japan

  • Medical Care and Research SA de CV

    NOT_YET_RECRUITING

    Mérida, 97070, Mexico

  • MentalMEDIC

    NOT_YET_RECRUITING

    Bielsko-Biala, 43-300, Poland

  • Miki Mental Clinic

    RECRUITING

    Yokohama, 220-0023, Japan

  • Monzen-nakacho Mental Clinic

    RECRUITING

    Kōtō City, 135-0047, Japan

  • Multidisciplinary Alfred Psychiatry Research Centre

    RECRUITING

    Melbourne, 3004, Australia

  • Multidisciplinary Mental Health Hospital of Attiki

    NOT_YET_RECRUITING

    Athens, 124 62, Greece

  • Multidisciplinary Mental Health Hospital of Thessaloniki

    NOT_YET_RECRUITING

    Stavroupoli, 564 29, Greece

  • NZOZ Psychiatrycznej Mentis

    NOT_YET_RECRUITING

    Leszno, 64-100, Poland

  • Nanko Kokorono Clinic

    RECRUITING

    Shirakawa, 961-0021, Japan

  • National Cheng Kung University Hospital

    RECRUITING

    Tainan, 704, Taiwan

  • National Taiwan University Hospital

    RECRUITING

    Taipei, 10002, Taiwan

  • NeuroCentrix

    RECRUITING

    Carlton, 3053, Australia

  • Neurozentrum Bielefeld

    RECRUITING

    Bielefeld, 33647, Germany

  • Northwest Clinical Research Center

    RECRUITING

    Bellevue, Washington, 98007, United States

  • Optimal Research Sites

    RECRUITING

    Orange City, Florida, 32763, United States

  • Papageorgiou General Hospital of Thessaloniki

    NOT_YET_RECRUITING

    Thessaloniki, 564 29, Greece

  • Paratus Clinical Research - Melbourne

    RECRUITING

    Melbourne, 3070, Australia

  • Parc de Salut Mar - Hospital del Mar

    RECRUITING

    Barcelona, 08003, Spain

  • Peking University Sixth Hospital

    RECRUITING

    Haidian District, 100191, China

  • Penn Medicine: University of Pennsylvania Health System

    RECRUITING

    Philadelphia, Pennsylvania, 19104, United States

  • Pharmakologisches Studienzentrum Chemnitz

    RECRUITING

    Chemnitz, 09111, Germany

  • Pharmasite Research, Inc.

    RECRUITING

    Baltimore, Maryland, 21208, United States

  • Podlaskie Centrum Psychogeriatrii

    NOT_YET_RECRUITING

    Bialystok, 15-756, Poland

  • Premier Clinical Trial Network

    NOT_YET_RECRUITING

    Hamilton, L8L 5G4, Canada

  • Private Practice - Dr. Małgorzata Wojtanowska-Bogacka

    NOT_YET_RECRUITING

    Poznan, 60-192, Poland

  • Queen Elizabeth University Hospital

    RECRUITING

    Glasgow, G51 4TF, United Kingdom

  • Queen's Medical Centre, Nottingham University Hospitals

    RECRUITING

    Nottingham, NG7 2UH, United Kingdom

  • Rainbow and Sea Hospital

    RECRUITING

    Karatsu, 847-0031, Japan

  • Re:Cognition Health

    RECRUITING

    Fairfax, Virginia, 22031, United States

  • Re:Cognition Health - Fort Worth

    RECRUITING

    Fort Worth, Texas, 76104, United States

  • Renmin Hospital of Wuhan University

    RECRUITING

    Wuhan, 430060, China

  • Richmond Clinical Trials

    RECRUITING

    Richmond, V6V 2L1, Canada

  • Ruschel Medicina e Pesquisa Clínica

    RECRUITING

    Rio de Janeiro, 22270-060, Brazil

  • SCB Research Center

    RECRUITING

    Bayamón, 00961, Puerto Rico

  • Sakurazaka Clinic SophyAnce

    RECRUITING

    Tokyo, 106-0032, Japan

  • Samsung Medical Center

    RECRUITING

    Seoul, 06351, South Korea

  • Sangenjaya Shinkeika Shinryonaika Clinic

    RECRUITING

    Setagaya City, 154-0004, Japan

  • Scientia Investigacion Clinica S.C.

    NOT_YET_RECRUITING

    Chihuahua City, 31207, Mexico

  • Senzoku Psychosomatic Medicine Clinic

    RECRUITING

    Meguro-ku, 152-0012, Japan

  • Seoul National University Hospital

    RECRUITING

    Seoul, 03080, South Korea

  • Severance Hospital, Yonsei University Health System

    RECRUITING

    Seoul, 03722, South Korea

  • Shandong Daizhuang Hospital

    RECRUITING

    Jining, 272051, China

  • Shanghai Mental Health Center

    RECRUITING

    Shanghai, 200030, China

  • Shioiri Mental Clinic

    RECRUITING

    Yokosuka, 238-0042, Japan

  • Somni bene

    RECRUITING

    Schwerin, 19053, Germany

  • St Bartholomew's Medical Centre

    RECRUITING

    Oxford, OX4 1XB, United Kingdom

  • Suburban Research Associates

    RECRUITING

    Media, Pennsylvania, 19063, United States

  • Suizenji Life Clinic

    RECRUITING

    Kumamoto, 862-0956, Japan

  • Summit Headlands

    RECRUITING

    Portland, Oregon, 97210, United States

  • Suzhou Guangji Hospital

    RECRUITING

    Suzhou, 215003, China

  • Taipei Medical University Hospital

    RECRUITING

    Taipei, 110, Taiwan

  • Taipei Veterans General Hospital

    RECRUITING

    Taipei, 11217, Taiwan

  • The Affilicated Kangning Hospital of Ningbo University

    RECRUITING

    Ningbo, 315201, China

  • The Catholic Univ. of Korea Seoul St. Mary's Hospital

    RECRUITING

    Seoul, 06591, South Korea

  • The First Affiliated Hospital of Nanchang University

    RECRUITING

    Nanchang, 330000, China

  • The First Hospital of Hebei Medical University

    RECRUITING

    Shijiazhuang, 050031, China

  • The Fourth People's Hospital of Chengdu

    RECRUITING

    Chengdu, 610036, China

  • The Maudsley Hospital

    RECRUITING

    London, SE5 8AZ, United Kingdom

  • The Second People's Hospital of Hunan Province

    RECRUITING

    Changsha, 410007, China

  • Tianjin Anding Hospital

    RECRUITING

    Tianjin, 300022, China

  • Toowoomba Hospital

    RECRUITING

    Toowoomba, 4350, Australia

  • Trial Tech

    RECRUITING

    Curitiba, 80240-280, Brazil

  • Uematsu Mental Clinic

    RECRUITING

    Chikugo, 833-0041, Japan

  • University of the Ryukyus Hospital

    RECRUITING

    Ginowan, 901-2725, Japan

  • Universitätsklinikum Aachen

    RECRUITING

    Aachen, 52074, Germany

  • Universitätsmedizin Johannes Gutenberg Universität Mainz

    NOT_YET_RECRUITING

    Mainz, 55131, Germany

  • Vector Clinical Trials

    RECRUITING

    Las Vegas, Nevada, 89128, United States

  • Warneford Hospital

    RECRUITING

    Oxford, OX3 7JX, United Kingdom

  • Westmead Hospital

    RECRUITING

    Westmead, 2145, Australia

  • Woodstock Bower Surgery

    RECRUITING

    Rotherham, S61 1AH, United Kingdom

  • Wuxi Mental Health Center

    RECRUITING

    Wuxi, 214151, China

  • Xi An Mental Health Center

    RECRUITING

    Xi'an, 710061, China

  • Xianyang Hospital of Yan'an University

    RECRUITING

    Xianyang, 712000, China

  • Yale University School of Medicine

    RECRUITING

    New Haven, Connecticut, 06519, United States

  • Yamagata Sakuracho Hospital

    RECRUITING

    Yamagata, 990-0045, Japan

  • Yuge Hospital

    RECRUITING

    Kumamoto, 861-8002, Japan

  • Yutaka Clinic

    RECRUITING

    Sagamihara, 252-0303, Japan

  • ZNS Siegen

    NOT_YET_RECRUITING

    Siegen, 57076, Germany

  • Zhumadian Psychiatric Hospital

    RECRUITING

    Zhumadian, 463000, China

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