DEPRESSIVE DISORDER, MAJOR

This study tests whether adding the anti-inflammatory drug celecoxib to standard depression treatment can improve symptoms in people with a specific subtype called immuno-metabolic depression (IMD). IMD is marked by symptoms like increased appetite, weight gain, and fatigue, alon…

This study tests whether a single dose of psilocybin (the active ingredient in magic mushrooms) can safely reduce depression symptoms in adults with major depressive disorder. About 238 participants will receive either 25 mg, 5 mg, or a placebo, and their mood changes will be tra…

This study aimed to see if a mild electrical brain stimulation called tDCS could help people with severe depression that didn't improve after many other treatments. Participants would have received either real or fake stimulation alongside their usual care. However, the study was…

This study tests a fast-acting brain stimulation technique called accelerated intermittent theta-burst stimulation (aiTBS) to see if it can reduce depression in people with borderline personality disorder (BPD). Researchers will compare active stimulation to a sham (fake) treatme…

This study tests whether choosing depression treatments based on a patient's specific symptoms and brain imaging (phenotyping) leads to better results than standard care. About 150 adults with major depression will be enrolled. The goal is to see if personalized treatment selecti…

This study aimed to see if a rapid form of brain stimulation (accelerated TMS) could reduce suicidal thinking in people hospitalized with major depression. It was designed for adults aged 22-65. However, the study was withdrawn before any participants were enrolled, so no results…

This study planned to check if measuring sertraline levels in the blood and looking at a specific gene (CYP2C19) could help doctors give the right dose to people with major depression. It aimed to see if many patients get too much or too little medicine with standard dosing. Howe…

This study looks at whether electroconvulsive therapy (ECT) or antidepressant medication is more cost-effective for treating severe major depression. Researchers will follow 220 adults in the Netherlands who have not gotten better with at least one antidepressant. The goal is to …

This study aimed to use low-intensity focused ultrasound to temporarily change brain activity in healthy volunteers and see how it affects emotion and thinking. The goal was to learn more about how the brain works, not to treat any disease. The study was withdrawn before any part…

This study aims to collect DNA, brain images, and other biological samples from 2,000 people with major depression, bipolar disorder, or psychotic disorders, as well as healthy volunteers. By analyzing these samples and detailed clinical assessments, researchers hope to find phys…