DEPRESSIVE DISORDER, MAJOR
Clinical trials for DEPRESSIVE DISORDER, MAJOR explained in plain language.
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Zapping depression away: brain stimulation trial for hopeless cases
Disease control TerminatedThis study aimed to test whether gentle electrical brain stimulation could help people with severe depression that hasn't improved with at least five different antidepressant medications or other treatments. Participants would have received either real or fake stimulation session…
Matched conditions: DEPRESSIVE DISORDER, MAJOR
Phase: NA • Sponsor: University of Alberta • Aim: Disease control
Last updated Mar 30, 2026 14:35 UTC
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Scientists test if depression subtypes need different treatments
Disease control ENROLLING_BY_INVITATIONThis study is testing whether matching depression treatments to a person's specific symptoms works better than standard care. Researchers will first sort 150 adults with major depression into one of five subtypes, like trouble feeling pleasure or high anxiety. Then, half will get…
Matched conditions: DEPRESSIVE DISORDER, MAJOR
Phase: PHASE4 • Sponsor: University of California, San Francisco • Aim: Disease control
Last updated Mar 30, 2026 14:33 UTC
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Magic mushroom compound enters final testing for depression
Disease control OngoingThis large, late-stage study is testing whether a single dose of psilocybin, the active compound in 'magic mushrooms,' can help treat major depression. About 240 adults with moderate to severe depression will receive either a high dose, a low dose, or a placebo pill, all with pro…
Matched conditions: DEPRESSIVE DISORDER, MAJOR
Phase: PHASE3 • Sponsor: Usona Institute • Aim: Disease control
Last updated Mar 30, 2026 14:28 UTC
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Brain zap trial aims to rapidly quiet suicidal thoughts
Symptom relief TerminatedThis study aimed to test a fast-paced, non-invasive brain stimulation technique to quickly reduce suicidal thoughts in hospitalized patients with severe depression. It planned to measure changes in suicidal thinking and depression symptoms immediately after treatment. The trial w…
Matched conditions: DEPRESSIVE DISORDER, MAJOR
Phase: NA • Sponsor: Stanford University • Aim: Symptom relief
Last updated Mar 30, 2026 14:29 UTC
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Brain zaps tested to lift depression in complex personality disorder
Symptom relief OngoingThis Stanford University study is testing whether a faster form of non-invasive brain stimulation can help reduce depressive symptoms in people who have both borderline personality disorder (BPD) and depression. The study compares real magnetic stimulation targeted at two differe…
Matched conditions: DEPRESSIVE DISORDER, MAJOR
Phase: NA • Sponsor: Stanford University • Aim: Symptom relief
Last updated Mar 23, 2026 15:18 UTC
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Scientists use sound waves to map the Brain's emotional center
Knowledge-focused TerminatedThis study aimed to understand how a gentle, non-invasive ultrasound technique affects brain activity related to emotions and thinking in healthy volunteers. Researchers planned to use brain scans to see if the ultrasound could safely change activity in areas linked to mood. The …
Matched conditions: DEPRESSIVE DISORDER, MAJOR
Phase: NA • Sponsor: The University of Texas Health Science Center, Houston • Aim: Knowledge-focused
Last updated Mar 30, 2026 14:34 UTC
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Scientists hunt for genetic clues behind depression and psychosis
Knowledge-focused ENROLLING_BY_INVITATIONThis research project aims to understand the genetic and biological roots of serious mental health conditions like major depression, bipolar disorder, and psychotic disorders. It involves collecting DNA, brain scans, and detailed health information from 2,000 participants, includ…
Matched conditions: DEPRESSIVE DISORDER, MAJOR
Sponsor: Vanderbilt University • Aim: Knowledge-focused
Last updated Mar 30, 2026 14:32 UTC
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Real-World look at how doctors treat stubborn depression
Knowledge-focused OngoingThis study aims to understand how doctors treat people with major depression who still feel a loss of pleasure and haven't responded well to their first antidepressant. It will observe 545 participants in their regular care, tracking what treatments they receive and how their sym…
Matched conditions: DEPRESSIVE DISORDER, MAJOR
Sponsor: Janssen Research & Development, LLC • Aim: Knowledge-focused
Last updated Mar 30, 2026 14:31 UTC