DEPRESSIVE DISORDER, MAJOR

This study tested whether adding aticaprant to a standard antidepressant helps adults with major depression who still feel little interest or pleasure (anhedonia). About 444 people took either aticaprant or a placebo pill for 6 weeks. Researchers measured changes in depression an…

This study tested if computer-based cognitive fitness activities could improve thinking and depression in 38 older adults who were already taking antidepressants. Participants did brain training exercises, and researchers measured changes in their mental flexibility, memory, and …

This study tested whether adding seltorexant, a sleep aid, to standard antidepressants helps adults with major depression who still have insomnia and depressive symptoms. About 588 participants took either seltorexant or a placebo for 6 weeks, then some continued on seltorexant l…

This study tested a new oral drug called zelquistinel in 251 adults with major depression. The goal was to see if a single dose could reduce depression symptoms within one day compared to a placebo. Results focus on changes in a standard depression rating scale.

This small study tested whether cannabis oil can improve sleep in people with major depression and insomnia. 14 adults took either cannabis oil or a placebo to see if it helped them fall asleep faster and sleep better. The goal was to see if a larger study is possible and if diff…

This study tested whether a single 25 mg dose of psilocybin (the active ingredient in magic mushrooms) could reduce depression symptoms in 347 adults with major depressive disorder. Participants received either psilocybin or a placebo (niacin) and were followed for 43 days. The g…

This study tested an experimental medicine called BI 1569912 in 243 adults with major depression whose previous treatments didn't work. Participants took either a placebo or one of three doses of the medicine daily for 6 weeks, while continuing their usual therapy. The goal was t…

This study explored whether daily training with different odors can improve both smell function and emotional well-being in people with mild depressive symptoms or major depression. Researchers enrolled 150 participants, including healthy volunteers and depressed patients, who pr…

This study tested a drug called aticaprant in 513 adults with major depression who still had symptoms—especially loss of interest or pleasure (anhedonia)—even with their current antidepressant. Participants took either aticaprant or a placebo pill alongside their usual antidepres…

This study checked the long-term safety of esketamine nasal spray for adults with treatment-resistant major depression who had already used it for 32 weeks. Participants continued the spray along with their usual antidepressant pills. The main goal was to track side effects over …

This study tested a new, non-invasive light therapy for major depression. 50 adults received either real or fake light treatment on their foreheads three times a week for six weeks. The goal was to see if the light could improve mood and brain function. Researchers measured depre…

This study looked at data from nearly 10,000 people to find out which depression medications (duloxetine or vortioxetine) work best for different types of patients. Researchers combined information from clinical trials and electronic health records. The goal was to develop method…

This study looked at 545 adults with major depression who also had a loss of interest or pleasure (anhedonia) and whose current antidepressants weren't working well enough. Researchers tracked their personal and medical details, as well as the real-life treatments they received, …

This study used brain scans (fMRI) to see how people with major depression think during different mental states. Researchers aimed to identify brain patterns linked to negative thinking and how the brain might disengage from them. 89 adults with depression took part, and the find…