New depression pill shows promise in early trial

NCT ID NCT03586427

First seen Apr 11, 2026 · Last updated May 15, 2026 · Updated 5 times

Summary

This study tested a new oral drug called zelquistinel in 251 adults with major depression. The goal was to see if a single dose could reduce depression symptoms within one day compared to a placebo. Results focus on changes in a standard depression rating scale.

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Contacts and locations

Locations

  • Atlanta Center for Medical Research

    Atlanta, Georgia, 30331, United States

  • Boston Clinical Trials

    Boston, Massachusetts, 02131, United States

  • Center for Emotional Fitness

    Cherry Hill, New Jersey, 08002, United States

  • Clinical Neuroscience Solutions, Inc - Memphis, TN

    Memphis, Tennessee, 38119, United States

  • Collaborative Neuroscience Network

    Torrance, California, 90502, United States

  • Donald J. Garcia, Jr., MD, PA

    Austin, Texas, 78737, United States

  • Eastside Comprehensive Medical Center

    New York, New York, 10128, United States

  • Elite Clinical Trials, Inc.

    Wildomar, California, 92595, United States

  • Finger Lakes Clinical Research

    Rochester, New York, 14618, United States

  • FutureSearch Trials of Dallas, LP

    Dallas, Texas, 75231, United States

  • Hassman Research Institute

    Berlin, New Jersey, 08009, United States

  • Health Initiatives Research PLLC

    Fayetteville, Arkansas, 72703, United States

  • IPS Research

    Oklahoma City, Oklahoma, 73106, United States

  • Neuro-Behavioral Clinical Research, Inc

    North Canton, Ohio, 44720, United States

  • Neurobehavioral Research, Inc

    Cedarhurst, New York, 11516, United States

  • North County Clinical Research, Inc.

    Oceanside, California, 92054, United States

  • Northwest Clinical Research Center

    Bellevue, Washington, 98007, United States

  • Pacific Research Partners, LLC

    Oakland, California, 94607, United States

  • Pillar Clinical Research

    Lincolnwood, Illinois, 60712, United States

  • Research Strategies of Memphis, LLC

    Memphis, Tennessee, 38119, United States

  • Synexus US - Atlanta

    Atlanta, Georgia, 30328, United States

  • Synexus US - Cerritos

    Cerritos, California, 90703, United States

  • Synexus US - Queens

    Jamaica, New York, 11432, United States

  • Wake Research - Pharmacology Research Institute

    Encino, California, 91316, United States

  • Wake Research - Pharmacology Research Institute

    Newport Beach, California, 92660, United States

Conditions

Explore the condition pages connected to this study.