New pill aims to lift depression by fixing sleep

NCT ID NCT04533529

First seen May 13, 2026 · Last updated May 15, 2026 · Updated 2 times

Summary

This study tested whether adding seltorexant, a sleep aid, to standard antidepressants helps adults with major depression who still have insomnia and depressive symptoms. About 588 participants took either seltorexant or a placebo for 6 weeks, then some continued on seltorexant long-term to check safety. The goal was to see if the combination improves mood and sleep better than antidepressants alone.

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Contacts and locations

Locations

  • A Shine S R O

    Pilsen, 31200, Czechia

  • APG Research LLC

    Orlando, Florida, 32803, United States

  • Adams Clinical

    Watertown, Massachusetts, 02472, United States

  • Advanced Research Center Inc

    Anaheim, California, 92805, United States

  • Affecta Pskyiatrimottagning

    Halmstad, SE-30248, Sweden

  • Alpine Research Organization

    Clinton, Utah, 84015, United States

  • Altea Research Institute

    Las Vegas, Nevada, 89102, United States

  • Ambulatory for Individual Practice for Specialized Medical Care in Psychiatry Dr. Ivo Natsov ET

    Cherven Bryag, 5980, Bulgaria

  • American Medical Research, Inc.

    Oak Brook, Illinois, 60523, United States

  • BRAIN-SOULTHERAPY s.r.o.

    Kladno, 27201, Czechia

  • Baber Research Group

    Naperville, Illinois, 60563, United States

  • Baylor College of Medicine

    Houston, Texas, 77030, United States

  • Bekhterev Psychoneurological Research Institute

    Saint Petersburg, 192019, Russia

  • Bind Investigaciones S.C.

    San Luis Potosí City, 78213, Mexico

  • Bioscience Research LLC

    Mount Kisco, New York, 10549, United States

  • Bravo Health Care Center

    North Bay Village, Florida, 33141, United States

  • CCB Centro Cardiologico de Brasilia Ltda - CCB Cardiologia

    Brasília, 70200-730, Brazil

  • CPN - Centro de Pesquisa em Neurociências Ltda

    Belo Horizonte, 30150-270, Brazil

  • CRI Centro Regiomontano de Investigacion SC

    Nuevo León, 64060, Mexico

  • Cape Town Clinical Research Centre

    Cape Town, 7530, South Africa

  • Catalina Research Institute

    Montclair, California, 91763, United States

  • Centro Salud Mental La Corredoria

    Oviedo, 33011, Spain

  • Centro de Investigaciones del Sistema Nervioso Grupo Cisne Ltda.

    Bogotá, 111166, Colombia

  • Centro de Investigaciones y Proyectos en Neurociencias CIPNA

    Barranquilla, Colombia

  • Centro de salud San Juan - IBSAL

    Salamanca, 37005, Spain

  • Chang Gung Memorial Hospital- Linkou

    Taoyuan County, 33305, Taiwan

  • Chang-Gung Memorial Hospital-Keelung

    Keelung, 204, Taiwan

  • Cheng Hsin General Hospital

    Taipei, 112, Taiwan

  • City Psychiatric Hospital of St. Nikolay Chudotvorets

    Saint Petersburg, 190121, Russia

  • Clinica Univ. de Navarra

    Pamplona, 31008, Spain

  • Clinical NeuroScience Solutions Inc

    Jacksonville, Florida, 32256, United States

  • Clintrial s r o

    Prague, 10000, Czechia

  • Combined Research Orlando

    Orlando, Florida, 32803, United States

  • Connecticut Clinical Trials LLC

    Cromwell, Connecticut, 06416, United States

  • Corporacio Sanitari Parc Tauli

    Sabadell, 08208, Spain

  • DCC 'Sv. Vrach and Sv. Sv. Kuzma and Damyan', OOD

    Sofia, 1408, Bulgaria

  • DJW Research

    Krugersdorp, 1739, South Africa

  • Farmovs Pty Ltd

    Bloemfontein, 9301, South Africa

  • Flexivest 14 Research

    Cape Town, 7530, South Africa

  • Fundacion Centro de Investigacion Clinica CIC

    Medellín, Colombia

  • Galiz Research

    Miami Springs, Florida, 33166, United States

  • Green Mountain Research Institute

    Rutland, Vermont, 05701, United States

  • HOMO - ESE Hospital Mental de Antioquia

    Bello, 051053, Colombia

  • Haidar Almhana Nieding

    Avon Lake, Ohio, 44012, United States

  • Hassman Research Institute, LLC.

    Berlin, New Jersey, 08009, United States

  • Hosp Univ Vall D Hebron

    Barcelona, 08035, Spain

  • Hosp. Prov. de Zamora

    Zamora, 49021, Spain

  • Hosp. Univ. La Paz

    Madrid, 28046, Spain

  • Hosp. Univ. Ramon Y Cajal

    Madrid, 28034, Spain

  • Hosp. Univ. de Basurto

    Bilbao, 48013, Spain

  • Iatros International

    Bloemfontein, 9324, South Africa

  • Iecsi S.C.

    Monterrey, 64310, Mexico

  • Institucion Hosp Hestia Palau

    Barcelona, 08025, Spain

  • Instituto Bairral de Psiquiatria

    São Paulo, 13970-905, Brazil

  • Instituto Mederi de Pesquisa e Saude

    Passo Fundo, 99010-120, Brazil

  • Instituto de Neurologia de Curitiba

    Curitiba, 81210-310, Brazil

  • Irvine Clinical Research

    Irvine, California, 92614, United States

  • Joliet Center for Clinical Research

    Joliet, Illinois, 60435, United States

  • Lehigh Center for Clinical Research

    Allentown, Pennsylvania, 18104, United States

  • Lindner Center of Hope

    Mason, Ohio, 45040, United States

  • Louisiana Clinical Research

    Shreveport, Louisiana, 71101, United States

  • Läkarmottagningen

    Skövde, 54143, Sweden

  • MHC - Sofia, EOOD

    Slivnitsa, 1202, Bulgaria

  • Mackay Memorial Hospital

    Taipei, 10449, Taiwan

  • Medical Center Intermedica, OOD

    Sofia, 1680, Bulgaria

  • Medical Center St. Naum

    Sofia, 1113, Bulgaria

  • Medical Research Center of Miami II Inc

    Miami, Florida, 33134, United States

  • Medical Services Prague S R O

    Prague, 16000, Czechia

  • Medical center - VAS OOD

    Targovishte, 7700, Bulgaria

  • Medical center Spectar - Plovdiv EOOD

    Plovdiv, 4000, Bulgaria

  • Mental Health Center - Vratsa EOOD

    Vratsa, 3000, Bulgaria

  • Mental Health Center Prof. Dr. Ivan Temkov

    Burgas, 8001, Bulgaria

  • Mid-America Clinical Research, LLC

    St Louis, Missouri, 63109, United States

  • Midwest Research Group - St. Charles Psychiatric Associates

    Saint Charles, Missouri, 63301, United States

  • National Taiwan University Hospital

    Taipei, 10002, Taiwan

  • Neurobehavioral Medicine Group

    Bloomfield Hills, Michigan, 48302, United States

  • Neuroterapie KH S R O

    Kutná Hora, 284 01, Czechia

  • North County Clinical Research

    Oceanside, California, 92056, United States

  • North Texas Clinical Trials

    Fort Worth, Texas, 76104, United States

  • Nova Psychiatry INC

    Orlando, Florida, 32803, United States

  • Oklahoma Clinical Research Center

    Oklahoma City, Oklahoma, 73112, United States

  • Omega Clinical Trials LLC

    La Habra, California, 90631, United States

  • Pacific Research Partners

    Oakland, California, 94607, United States

  • PharmaSite

    Malmö, 21152, Sweden

  • PharmaSite Helsingborg

    Helsingborg, 25220, Sweden

  • Pharmax Research Clinic Inc

    Miami, Florida, 33126, United States

  • Phoenix Medical Research, Inc.

    Miami, Florida, 33165, United States

  • Premier Psychiatric Research Institute, LLC

    Lincoln, Nebraska, 68526, United States

  • ProbarE i Lund AB

    Lund, 22222, Sweden

  • ProbarE i Solna

    Stockholm, 111 37, Sweden

  • PsychCare Consultants Research

    St Louis, Missouri, 63128, United States

  • Psychoneurological Dispensary of Frunzensky District

    Saint Petersburg, 190013, Russia

  • Psychoneurological dispensary 1

    Saint Petersburg, 199106, Russia

  • Psynapsis Salud Mental S.A.

    Pereira, Colombia

  • Red Oak Psychiatry Associates

    Houston, Texas, 77090, United States

  • Relaro Medical Trials

    Dallas, Texas, 75243, United States

  • Revive Research Institute

    Elgin, Illinois, 60123, United States

  • Ruschel Medicina e Pesquisa Clínica Ltda

    Rio de Janeiro, 22270 060, Brazil

  • SPDM - Associacao Paulista para o Desenvolvimento da Medicina - Hospital Sao Paulo

    São Paulo, 04037-003, Brazil

  • SPb SBIH 'City Psychoneurological Dispensary # 7 (With Inpatient Facilities)'

    Saint Petersburg, 190020, Russia

  • Sarkis Clinical Trials

    Gainesville, Florida, 32607, United States

  • Semel Institute for Neuroscience and Human Behavior

    Los Angeles, California, 90048, United States

  • Somerset West Clinical Research Unit

    Strand, 7140, South Africa

  • Southern Illinois University School of Medicine

    Springfield, Illinois, 62701, United States

  • St-Petersburg Bekhterev Psychoneurological Research Institute

    Saint Petersburg, 192019, Russia

  • Stanza Clinical Research Centre : Mamelodi

    Mamelodi East, 0122, South Africa

  • State Psychiatric Hospital Kardzhali

    Kardzhali, 6600, Bulgaria

  • Stavropol Region Psychiatric Hospital #2

    Stavropol, 357034, Russia

  • Synergy East

    Lemon Grove, California, 91945, United States

  • Synexus

    Cerritos, California, 90703, United States

  • Synexus Clinical Research US Inc

    Jamaica, New York, 11432, United States

  • Synexus Watermeyer

    Pretoria, South Africa

  • Syrentis Clinical Research

    Santa Ana, California, 92705, United States

  • Taipei Medical University

    Taipei, 110, Taiwan

  • Taipei Veterans General Hospital

    Taipei, 112, Taiwan

  • The Ohio State University

    Columbus, Ohio, 43221, United States

  • UMHAT 'Sv. Georgi' EAD

    Plovdiv, 4000, Bulgaria

  • Universidade Federal do Ceara Hospital Universitario Walter Cantidio

    Fortaleza, 60430-380, Brazil

  • University of Connecticut Health Center

    Farmington, Connecticut, 06030, United States

  • University of Pennsylvania - Perelman School of Medicine

    Philadelphia, Pennsylvania, 19104, United States

  • Viking Pharmaceutical Trials Inc. dba Viking Clinical Research

    Temecula, California, 92591, United States

  • Yaroslavl Region Clinical Psychiatric Hospital

    Yaroslavl, 150003, Russia

Conditions

Explore the condition pages connected to this study.