DEPRESSIVE DISORDER, MAJOR

This study tested whether adding the drug aticaprant to standard antidepressants could prevent depression from returning in people with major depressive disorder who also experience a loss of interest or pleasure (anhedonia). The study enrolled 47 adults who had responded well to…

This study tested the long-term safety of a drug called aticaprant when added to a standard antidepressant for adults with major depression. The trial planned to enroll 871 people but was terminated early, so the full safety and effectiveness data are not available. Researchers w…

This study tested whether adding aticaprant to standard antidepressants could help people with major depression who still feel no pleasure (anhedonia). The trial was stopped early after enrolling only 101 participants. No results are available, so it is unknown if aticaprant work…

This study tested whether adding a type of talk therapy (behavioral activation) to esketamine treatment helps people with depression that hasn't improved with other treatments. Six adults with major depression or bipolar disorder took part. The goal was to see if practicing new b…

This study tested whether real-time fMRI neurofeedback could help young adults with major depression reduce repetitive negative thinking. Participants received either real or fake feedback while their brain activity was monitored. The trial was terminated early, so the findings a…