DEPRESSIVE DISORDER, MAJOR
Clinical trials for DEPRESSIVE DISORDER, MAJOR explained in plain language.
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Depression drug study halted: aticaprant safety trial ends early
Disease control TerminatedThis study looked at the long-term safety of a drug called aticaprant when taken together with standard antidepressants for people with major depressive disorder. About 871 adults were planned to join, but the study was stopped early. The main goal was to track side effects and s…
Matched conditions: DEPRESSIVE DISORDER, MAJOR
Phase: PHASE3 • Sponsor: Janssen Research & Development, LLC • Aim: Disease control
Last updated May 14, 2026 12:05 UTC
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Depression relapse prevention drug trial halted early
Disease control TerminatedThis study tested whether adding the drug aticaprant to standard antidepressants could prevent depression from returning in people with major depressive disorder who also experience a loss of interest or pleasure (anhedonia). The trial was stopped early and included 47 participan…
Matched conditions: DEPRESSIVE DISORDER, MAJOR
Phase: PHASE3 • Sponsor: Janssen Research & Development, LLC • Aim: Disease control
Last updated May 11, 2026 20:49 UTC
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Depression drug trial halted: did it fail to boost joy?
Symptom relief TerminatedThis study tested whether adding aticaprant to standard antidepressants could improve symptoms in adults with major depression who also have severe loss of interest or pleasure (anhedonia). About 101 people were enrolled, but the trial was stopped early. The goal was to measure c…
Matched conditions: DEPRESSIVE DISORDER, MAJOR
Phase: PHASE3 • Sponsor: Janssen Research & Development, LLC • Aim: Symptom relief
Last updated May 15, 2026 11:54 UTC
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New combo therapy shows promise for stubborn depression
Symptom relief TerminatedThis study tested whether adding a type of talk therapy (behavioral activation) to esketamine treatment helps people with depression that hasn't improved with standard medications. Six adults with major depression or bipolar disorder took part. The goal was to see if practicing n…
Matched conditions: DEPRESSIVE DISORDER, MAJOR
Phase: NA • Sponsor: The Royal's Institute of Mental Health Research • Aim: Symptom relief
Last updated Apr 30, 2026 15:50 UTC